Age.
Discontinued
Publisher:
Springer,
Frequency: Quarterly
Country: Netherlands
Language: English
Author(s):
American Aging Association., American College of Clinical Gerontology., International Association of Biomedical Gerontology.
Start Year:2005 - 2016
ISSN:
0161-9152 (Print)
1574-4647 (Electronic)
0161-9152 (Linking)
1574-4647 (Electronic)
0161-9152 (Linking)
Impact Factor
5.6
2022
| NLM ID: | 101250497 |
| (OCoLC): | 60689048 |
| LCCN: | 2005240586 |
| Classification: | W1 AG299 |
Changes in DNA methylation patterns and repetitive sequences in blood lymphocytes of aged horses. It is known that aged organisms have modified epigenomes. Epigenetic modifications, such as changes in global and locus-specific DNA methylation, and histone modifications are suspected to play an important role in cancer development and aging. In the present study, with the well-established horse aging model, we showed the global loss of DNA methylation in blood lymphocytes during juvenile-to-aged period. Additionally, we tested a pattern of DNA methylation of ribosomal DNA and selected genes such as IGF2 and found no significant changes during development and aging. We asked if genetic compo...