Search 62,254 equine research studies and published journal articles.
Exposure to chemical pollutants and biological aerosol in indoor facilities for recreational and sport horses.
BMC veterinary research    February 28, 2024   Volume 20, Issue 1 78 doi: 10.1186/s12917-024-03930-2
Rodzyu0144 I, Karpiu0144ska K, Bis-Wencel H, Wlazu0142o u0141, Ossowski M, Strzelec K, Jaguszewski S, Nowakowicz-Du0119bek B.Due to the increasing prevalence of equine non-infectious respiratory disease, the air contamination in equine housing (Stables A-C) and training facilities (indoor riding arenas A - C) was investigated. The aim of the study was to monitor gaseous pollutants, bioaerosols, and dust concentrations at three different sites (stables and riding halls), where different floor materials were used in the riding halls. Methods: Air quality was monitored in housing for horses and in riding halls in terms of dust concentration, the presence of gaseous chemical pollutants, and concentrations of biological ...
Comparison of plasma l-lactate between jugular and cephalic veins in healthy and systemically ill horses using a point-of-care device.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)    February 27, 2024   doi: 10.1111/vec.13364
Rhodes AD, Wilkins PA, McCoy AM.To compare plasma l-lactate (LAC) values between samples collected from jugular and cephalic venipuncture in healthy horses and systemically ill horses. Methods: Prospective, experimental study. Methods: Large animal university teaching hospital. Methods: Thirty healthy adult university-owned horses and 43 client-owned horses presenting to the large animal hospital for elective surgical procedures or for emergent medical evaluation of systemic illness. Methods: Blood samples were collected from the jugular vein (JV) and cephalic vein (CV) and placed in EDTA blood tubes prior to any medical the...
Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas.
PloS one    February 27, 2024   Volume 19, Issue 2 e0298660 doi: 10.1371/journal.pone.0298660
Galinelli NC, Bamford NJ, de Laat MA, Sillence MN, Harris PA, Bailey SR.Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin resistance and is associated with increased risk of laminitis. There is growing evidence in other species that dopamine attenuates insulin release from the pancreas; however, this has yet to be examined in horses. The present study aimed to identify whether there are cells capable of producing or responding to dopamine within the equine gastrointestinal mucosa and pancreas. Tissue samples were collected from the stomach, small and large intestines, and pancreas of six mature horses following euthanasia....
Correction to Identifying possible thresholds for nonstructural carbohydrates in the insulin dysregulated horse.
Equine veterinary journal    February 27, 2024   doi: 10.1111/evj.14078
No abstract available
Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage.
Journal of veterinary internal medicine    February 26, 2024   doi: 10.1111/jvim.17015
Miglio A, Rocconi F, Cremonini V, D'Alessandro A, Reisz JA, Maslanka M, Lacroix IS, Tiscar G, Di Tommaso M, Antognoni MT.Understanding of the biochemical and morphological lesions associated with storage of equine blood is limited. Objective: To demonstrate the temporal sequences of lipid and metabolic profiles of equine fresh and stored (up to 42 days) and leukoreduced packed red blood cells (LR-pRBC) and non-leukoreduced packed RBC (nLR-pRBC). Methods: Packed RBC units were obtained from 6 healthy blood donor horses enrolled in 2 blood banks. Methods: Observational study. Whole blood was collected from each donor using transfusion bags with a LR filter. Leukoreduction pRBC and nLR-pRBC units were obtained an...
Impact of Aspergillus fumigatus inoculation on the composting of wood shavings bedding for horses.
Letters in applied microbiology    February 26, 2024   ovae023 doi: 10.1093/lambio/ovae023
do Nascimento AGCR, de Paula AM, Busato JG, da Rocha GC, Perecmanis S, da Silva SG, Neto ART.Equine farming generates a significant amount of waste, prompting the need for effective management. Composting enhanced by filamentous fungi holds promise for this purpose. This study focused on inoculating Aspergillus fumigatus isolates in composting horse bedding made with wood shavings (Pinus elliottii) The experiment lasted 90 days, with two treatment groups, control and inoculated, analyzing temperature, pH, electrical conductivity, total organic carbon and nitrogen content, cellulose, hemicellulose and lignina contents. Both treatments entered the thermophilic phase by the fourth day, r...
Conductivity of mammary gland secretions is a sensitive and specific predictor of parturition in mares.
Equine veterinary journal    February 25, 2024   doi: 10.1111/evj.14070
Magalhaes HB, Colombo I, Spencer KM, Podico G, Canisso IF.Accurate prediction of parturition is paramount to ensuring monitoring of delivery and preventing complications. Assessing the pH and electrolytes of the mammary gland secretions (MGS) helps detect impending parturition. As conductivity is related to electrolyte concentrations and pH, it could be a useful alternative for predicting impending parturition; however, this hypothesis warrants a critical assessment. Objective: To assess the ability of conductivity, pH, and Brix in the MGS to predict parturition and to investigate their associations. Methods: Field study. Methods: The MGS of peripart...
Effects of repeated embryo flushing without PGF2α administration on luteal function, percentage of unwanted pregnancy and subsequent fertility in mares.
Equine veterinary journal    February 25, 2024   doi: 10.1111/evj.14073
Martu00ednez-Bovu00ed R, Sala-Ayala L, Querol-Paajanen A, Plaza-Du00e1vila M, Cuervo-Arango J.PGF is commonly given at the end of embryo flushing (EF) to shorten the interval to the next oestrus and ovulation. Objective: To determine the effect of repeated EF on plasma progesterone concentration, percentage of mares with endometritis, unwanted pregnancy and subsequent fertility in mares flushed without the use of PGF . Methods: Controlled experiments. Methods: Nine mares were inseminated in seven consecutive cycles (n = 63), to either perform an EF (n = 54) 7-9 days after ovulation or left pregnant (n = 9). PGF was not used to induce oestrus. Ultrasound examination and bl...
Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.
Stem cell reviews and reports    February 24, 2024   doi: 10.1007/s12015-024-10693-8
Smith EJ, Beaumont RE, Dudhia J, Guest DJ.Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contributes to fibrotic healing by disrupting tenocyte activity, with the NF-κB pathway being identified as a potential mediator. Equine embryonic stem cell (ESC) derived tenocytes may offer a potential cell-based therapy to improve tendon regeneration, but how they respond to an inflammatory environment is largely unknown. Our findings reveal for the firs...
A transmandibular lateral transsphenoidal navigated surgical approach to access a pituitary macroadenoma in a warmblood mare.
The veterinary quarterly    February 23, 2024   Volume 44, Issue 1 1-10 doi: 10.1080/01652176.2023.2300947
de Preux M, Precht C, Guevar J, Graubner C, Thenhaus-Schnabel S, Buser L, Lukes A, Koch C.A 16-year-old warmblood mare was referred with a progressive history of behavioral changes and left-sided blindness. Following neuroanatomical localization to the forebrain, magnetic resonance imaging of the head revealed a well-delineated, 4.5 cm in diameter, round pituitary mass causing marked compression of the midbrain and optic chiasm. Euthanasia was recommended but declined by the owners. Veterinary specialists and a human neurosurgeon collaboratively prepared for surgical case management. A novel navigated transmandibular lateral transsphenoidal approach was developed to access the re...
microRNAs are differentially expressed in equine plasma of horses with osteoarthritis and osteochondritis dissecans versus control horses.
PloS one    February 23, 2024   Volume 19, Issue 2 e0297303 doi: 10.1371/journal.pone.0297303
Antunes J, Salcedo-Jimu00e9nez R, Lively S, Potla P, Cotu00e9 N, Dubois MS, Koenig J, Kapoor M, LaMarre J, Koch TG.Osteoarthritis (OA) is a leading cause of lameness in horses with no effective disease-modifying treatment and challenging early diagnosis. OA is considered a disease of the joint involving the articular cartilage, subchondral bone, synovial membrane, and ligaments. Osteochondritis dissecans (OCD) is a joint disease consisting of focal defects in the osteochondral unit which may progress to OA later in life. MicroRNAs (miRNAs) have been recognized as small non-coding RNAs that regulate a variety of biological processes and have been detected in biological fluids. MiRNAs are currently investiga...
Morphological evidence of a potential arrhythmogenic substrate in the caudal and cranial vena cava in horses.
Equine veterinary journal    February 23, 2024   doi: 10.1111/evj.14075
Ibrahim L, Buschmann E, van Loon G, Cornillie P.Three-dimensional electro-anatomical mapping, previously performed in horses with atrial arrhythmias, has demonstrated the medial region of the caudal vena cava (CaVC), 1-8 cm caudal to the fossa ovalis, as an anatomical predilection site for atrial tachycardia associated with areas of slow conduction and conduction block. Slow conduction has also been recorded in the cranial vena cava (CrVC). Objective: To investigate the morphological characteristics of the myocardial sleeves (MS) in the CaVC and CrVC, in order to identify a potential substrate of right sided atrial arrhythmias. Methods: C...
Influence of screw configuration on reduction and stabilization of simulated complete lateral condylar fracture in equine limbs.
Veterinary surgery : VS    February 21, 2024   doi: 10.1111/vsu.14077
Brabon A, Hughes KJ, Jensen K, Xie G, Labens R.To determine the influence of screw configuration on the reduction and stabilization of simulated complete lateral condylar fracture. Methods: Randomized experimental crossover study. Methods: A lateral condylar fracture was simulated in 18 cadaver limbs from nine horses. Each limb underwent repair with 4.5 mm diameter cortex screws, tightened to 4 Nm, in a linear and triangular configuration. Computed tomography (CT) of each repair was performed with the limbs in unloaded and loaded conditions. Fracture gaps were measured at the dorsal, palmar, and middle locations of the third metacarpal c...
Intralesional interferon alpha-2b as a novel treatment for periocular squamous cell carcinoma in horses.
PloS one    February 21, 2024   Volume 19, Issue 2 e0297366 doi: 10.1371/journal.pone.0297366
Martabano BB, Dow S, Chow L, Williams MMV, Mack MK, Bellone R, Wotman KL.To determine the safety and efficacy of perilesional human recombinant interferon alpha-2b (IFNα2b) for treatment of periocular squamous cell carcinoma (PSCC) in horses. Methods: Eleven horses (12 eyes) with PSCC were enrolled in this prospective clinical study with owner consent. Methods: Systemically healthy horses were included in the study following confirmation of PSCC via biopsy. Every two weeks for a maximum of six treatments, horses were sedated and perilesional injection of IFNα2b (10 million IU) was performed. Tumors were measured prior to each injection and at one, three, and 12 m...
Influence of microarchitecture on stressed volume and mechanical fatigue behaviour of equine subchondral bone.
Bone    February 21, 2024   117054 doi: 10.1016/j.bone.2024.117054
Koshyk A, Pohl AJ, Takahashi Y, Scott WM, Sparks HD, Edwards WB.Fractures of the equine metacarpophalangeal (MCP) joint are among the most common and fatal injuries experienced by racehorses. These bone injuries are a direct result of repetitive, high intensity loading of the skeleton during racing and training and there is consensus that they represent a mechanical fatigue phenomenon. Existing work has found the fatigue life of bone to be strongly determined by bone microarchitecture and the resulting stressed volume (i.e., the volume of bone stressed above assumed yield). The purpose of this study was to quantify the influence of bone microarchitecture o...
Evaluation of the effectiveness of single nucleotide polymorphisms compared to microsatellite markers for parentage verification in Moroccan horses.
Animal genetics    February 21, 2024   doi: 10.1111/age.13408
Aminou O, Badaoui B, Machmoum M, Piro M.The International Society for Animal Genetics (ISAG) currently advocates for a transition towards single nucleotide polymorphism (SNP) markers as a potential alternative for equine parentage verification. To ascertain the efficacy of this transition, it is imperative to evaluate the performance of parentage testing using SNPs in juxtaposition with short tandem repeats (STRs). As per ISAG's recommendation, we used an equine genotyping-by-sequencing panel with 144 SNPs for this purpose. Equine parentage is currently realized using 16 microsatellites (STRs) excluding the LEX3 marker. In this stud...
Histologic and cytologic changes in normal equine joints after injection with 2.5% injectable polyacrylamide hydrogel reveal low-level macrophage-driven foreign body response.
Journal of the American Veterinary Medical Association    February 21, 2024   1-9 doi: 10.2460/javma.23.10.0553
Lowe J, Clifford L, Julian A, Koene M.The data presented in this paper are derived from an in vivo study performed to characterize the nature of the synovial integration process of a 2.5% synthetic cross-linked injectable polyacrylamide hydrogel (2.5 iPAAG) injected IA in horses. Methods: 10 healthy horses not suffering from OA or signs of joint disease were administered 50 or 100 mg 2.5 iPAAG in a total of 13 metacarpophalangeal or middle carpal joints. Methods: Injected joints were examined at 0, 14, 42, and/or 90 days postinjection. Parameters investigated included clinical examination, synoviocentesis, gross pathology, histolo...
International survey of equine orthopaedic specialists reveals diverse treatment strategies for horses with overriding spinous processes.
The Veterinary record    February 20, 2024   e3899 doi: 10.1002/vetr.3899
Treu00df D, Lischer C, Merle R, Ehrle A.Overriding spinous processes, also known as 'kissing spines', are one of the most common causes of back pain in horses. The aim of this study was to investigate which options for diagnosis and treatment are preferred by equine orthopaedic specialists and assess which techniques are used for local injection. Methods: An online survey was distributed among members of the European/American College of Veterinary Surgeons, the European/American College of Veterinary Sports Medicine and Rehabilitation, the International Society of Equine Locomotor Pathology and nationally recognised advanced equine ...
Anastomotic techniques for small intestinal obstruction in horses. A scoping review.
Equine veterinary journal    February 20, 2024   doi: 10.1111/evj.14076
Giusto G, Cerullo A, Gandini M.Small bowel obstruction (SBO) is a significant cause of surgery in adult horses presenting with colic pain. SBOs often require resection and anastomosis. While various techniques for intestinal anastomoses have been developed, it remains uncertain if any fully meet our clinical needs. Objective: To conduct a scoping review of publications on anastomosis techniques and outcomes for the treatment of SBO. Methods: Scoping review. Methods: A literature review was conducted using the CAB, Web of Science, Scopus, and PubMed databases. Peer-reviewed scientific articles in English, published between 1...
Effect of Hypotension and Dobutamine on Gastrointestinal Microcirculations of Healthy, Anesthetized Horses.
Veterinary sciences    February 19, 2024   Volume 11, Issue 2 95 doi: 10.3390/vetsci11020095
Kieffer PJ, Williams JM, Shepard MK, Giguu00e8re S, Epstein KL.Horses undergoing abdominal exploratory surgery are at risk of hypotension and hypoperfusion. Normal mean arterial pressure is used as a surrogate for adequate tissue perfusion. However, measures of systemic circulation may not be reflective of microcirculation. This study measured the mean arterial pressure, cardiac index, lactate, and four microcirculatory indices in six healthy, anesthetized adult horses undergoing elective laparotomies. The microcirculatory parameters were measured at three different sites along the gastrointestinal tract (oral mucosa, colonic serosa, and rectal mucosa) wi...
Leucaena leucocephala toxicity in Brazilian horses.
Toxicon : official journal of the International Society on Toxinology    February 19, 2024   107655 doi: 10.1016/j.toxicon.2024.107655
Machado M, Queiroz-Machado CRR, Gardner DR, Castro MB, Cu00e2mara ACL, Pimentel LA, Galiza GJN, Riet-Correa F.Leucaena leucocephala poisoning is reported in horses in different Brazilian regions. The poisoning occurred one month after the horses were introduced into paddocks invaded by the plant or after 10 days of consuming cut Leucaena administered as the only food. Affected horses showed moderate to severe hair loss on the mane and tail, orthokeratotic hyperkeratosis with marked follicular telogenization, and hyperplasia of thyroid follicular cells. Mimosin concentration in leaves (5.5 mg/g) was determined by a new HLPC-UV method which is also reported.
Comparison of forages’ digestion levels for different in vitro digestion techniques in horses
Veterinary medicine and science    February 19, 2024   Volume 10, Issue 2 e31373 doi: 10.1002/vms3.1373
Kara K, Altu0131nsoy A.Forages are widely used in horse diets. Different in vitro techniques are being tried to determine the fermentation levels of forages in the horse digestive tract. Objective: This study aimed to evaluate the digestion levels of four dry forages commonly used in horse nutrition: alfalfa herbage, meadow hay, wheat straw, and Italian ryegrass. In vitro total digestion (TDT), in vitro Sunvold-large intestine digestion (SDT) and in vitro Menke-large intestine digestion (MDT) techniques were compared. Methods: The study determined in vitro true dry matter digestion (T-DMD), in vitro true organic mat...
Characteristics of potential adopters of wild horses and their willingness-to-pay for wild horses.
Journal of applied animal welfare science : JAAWS    February 18, 2024   1-13 doi: 10.1080/10888705.2024.2317278
Stowe CJ, White H.An overabundance of wild horses and burros on federal lands can lead to suboptimal welfare when there are insufficient forage and water resources. Placing some of these animals in private homes has been identified as a key part of the solution. A nationwide online survey completed by 2,247 current and former horse owners is used to assess the feasibility of accommodating this strategy. The survey tool addressed basic horse ownership and demographic information, previous experience with wild horses, and hypothetical wild horse adoption scenarios. Results suggest that most respondents are recept...
Comparative proteomic analysis of the changes in mare milk associated with different lactation stages and management systems.
Food chemistry    February 17, 2024   Volume 445 138766 doi: 10.1016/j.foodchem.2024.138766
Blanco-Doval A, Azkargorta M, Iloro I, Beaskoetxea J, Elortza F, Barron LJR, Aldai N.Mare milk has traditionally been attributed a number of health promoting properties. However, knowledge on its composition and functionality remains scarce, with particularly limited studies on mare milk proteomics. This study deeply characterized mare milk proteome accounting for both caseins and proteins in the whey fraction, also addressing the impact of lactation stage and different management systems. Milk samples from Basque Mountain Horse breed mares belonging to three different farms and three lactation stages were analysed after in-gel and in-solution digestion using nLC-MS/MS. Among ...
Equine brucellosis in Iran: serological, bacteriological and molecular analysis.
Veterinary research communications    February 17, 2024   doi: 10.1007/s11259-024-10332-0
Amini M, Alamian S, Talebhemmat M, Dadar M.Equine brucellosis significantly impacts the health and functionality of horses, leading to complications such as bursitis infection, septic tenosynovitis, septic arthritis, and non-specific lameness resulting from joint infections. In the present study, we used the Rose Bengal plate agglutination test (RBPT), serum agglutination test (SAT), and the 2-mercaptoethanol (2-ME) assays to find equine brucellosis. From June 2018 to September 2022, 876 blood samples were randomly taken from apparently healthy racing horses in certain parts of Iran, such as Kerman, Isfahan, Tehran, Qom, and Kurdistan....
A case of non-mosaic X trisomy (65,XXX) in a Thoroughbred mare confirmed by cytogenetic and molecular analysis.
Journal of applied genetics    February 17, 2024   doi: 10.1007/s13353-024-00844-5
Cieslak J, Mackowski M, Skrzetuska W, Fidos-Tama E, Siwinska N, Szczerbal I.A 9-year-old Thoroughbred mare with normal external genitalia and regular oestrus symptoms was gynecologically examined prior to insemination. This primary examination revealed the presence of a hypoplastic uterus and the lack of normal ovaries, and the mare was therefore subjected to more detailed diagnostics, including endocrinological, genetic, and clinical tests. Diagnostic imaging with the use of ultrasonography and endoscopy confirmed the underdevelopment of internal genitalia. Analysis of circulating sex hormones revealed very low concentrations of progesterone and oestradiol. Finally, ...
Evaluation of blastocyst re-expansion, quality in relation to storage temperature, and sexing using blastocoel fluid after manual perforation with a hand-held needle involving in vivo produced equine embryos.
Theriogenology    February 16, 2024   Volume 219 39-48 doi: 10.1016/j.theriogenology.2024.02.012
Camargo GS, de Barros LD, Oliveira-Filho JP, Bromberger CR, Dias-Melicio LA, Alves Dos Santos L, Bergfelt DR, Ferraz de Andrade ER, Canesin HS....The present study was designed to evaluate equine blastocyst re-expansion rate, quality, and sex following perforation of the blastocoel, collection of blastocoel fluid (BF), and PCR amplification of free DNA. Experiment 1 tested the feasibility of the BF sample collection with a hand-held, small-gauged needle (26g) and subsequent PCR amplification of the TSP-Y gene for males and AMEL-Y gene for males and AMEL-X gene for females. Experiment 2 tested the application of the technique. Equine embryos were collected via uterine flushes 8d after ovulation. Thereafter, embryos (n = 19) were initia...
Bioinformatic analysis of endometrial miRNA expression profile at day 26-28 of pregnancy in the mare.
Scientific reports    February 16, 2024   Volume 14, Issue 1 3900 doi: 10.1038/s41598-024-53499-x
Sadowska A, Molcan T, Wu00f3jtowicz A, Lukasik K, Pawlina-Tyszko K, Gurgul A, Ferreira-Dias G, Skarzynski DJ, Szu00f3stek-Mioduchowska A.The establishment of the fetomaternal interface depends on precisely regulated communication between the conceptus and the uterine environment. Recent evidence suggests that microRNAs (miRNAs) may play an important role in embryo-maternal dialogue. This study aimed to determine the expression profile of endometrial miRNAs during days 26-28 of equine pregnancy. Additionally, the study aimed to predict target genes for differentially expressed miRNAs (DEmiRs) and their potential role in embryo attachment, adhesion, and implantation. Using next-generation sequencing, we identified 81 DEmiRs betwe...
Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation.
Journal of veterinary internal medicine    February 16, 2024   doi: 10.1111/jvim.17013
Kemp KL, Skinner JE, Bertin FR.Phenylbutazone is often prescribed to manage pain caused by hyperinsulinemia-associated laminitis, but in diabetic people nonsteroidal anti-inflammatory drugs increase insulin secretion and pancreatic activity. Objective: Investigate the effect of phenylbutazone administration on insulin secretion in horses. It was hypothesized that phenylbutazone will increase insulin secretion in horses with insulin dysregulation (ID). Methods: Sixteen light breed horses, including 7 with ID. Methods: Randomized cross-over study design. Horses underwent an oral glucose test (OGT) after 9 days of treatment ...
Reported Agonistic Behaviours in Domestic Horses Cluster According to Context.
Animals : an open access journal from MDPI    February 16, 2024   Volume 14, Issue 4 629 doi: 10.3390/ani14040629
Fenner K, Wilson BJ, Ermers C, McGreevy PD.Agonistic behaviours are often directed at other animals for self-defence or to increase distance from valued resources, such as food. Examples include aggression and counter-predator behaviours. Contemporary diets may boost the value of food as a resource and create unanticipated associations with the humans who deliver it. At the same time the domestic horse is asked to carry the weight of riders and perform manoeuvres that, ethologically, are out-of-context and may be associated with instances of pain, confusion, or fear. Agonistic responses can endanger personnel and conspecifics. They are...
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