Topic:Equine Health

Effect of storage conditions on the quality of equine and canine mesenchymal stem cell derived nanoparticles including extracellular vesicles for research and therapy.
Discover nano    May 3, 2024   Volume 19, Issue 1 80 doi: 10.1186/s11671-024-04026-4
Klymiuk MC, Balz N, Elashry MI, Wenisch S, Arnhold S.Nanoparticles including extracellular vesicles derived from mesenchymal stem cells are of increasing interest for research and clinical use in regenerative medicine. Extracellular vesicles (EVs), including also previously named exosomes, provide a promising cell-free tool for therapeutic applications, which is probably a safer approach to achieve sufficient healing. Storage of EVs may be necessary for clinical applications as well as for further experiments, as the preparation is sometimes laborious and larger quantities tend to be gained. For this purpose, nanoparticles were obtained from mes...
Preliminary study of proton magnetic resonance spectroscopy to assess bone marrow adiposity in the third metacarpus or metatarsus in Thoroughbred racehorses.
Equine veterinary journal    May 3, 2024   doi: 10.1111/evj.14086
Hewitt-Dedman CL, Kershaw LE, Schwarz T, Del-Pozo J, Duncan J, Daniel CR, Cillu00e1n-Garcu00eda E, Pressanto MC, Taylor SE.Magnetic resonance spectroscopy (MRS) has been used to investigate metabolic changes within human bone. It may be possible to use MRS to investigate bone metabolism and fracture risk in the distal third metacarpal/tarsal bone (MC/MTIII) in racehorses. Objective: To determine the feasibility of using MRS as a quantitative imaging technique in equine bone by using the H spectra for the MC/MTIII to calculate fat content (FC). Methods: Observational cross-sectional study. Methods: Limbs from Thoroughbred racehorses were collected from horses that died or were subjected to euthanasia on racecourses...
Is it pain, or is it behaviour?
The Veterinary record    May 3, 2024   Volume 194 Suppl 1 9 doi: 10.1002/vetr.4204
Pearson G.This year BVA Live will, for the first time, feature farm animal and equine CPD. Among the varied topics on offer, Gemma Pearson will be presenting an introduction to equine behavioural medicine, examining the link between emotional and physical health in horses.
Serum concentrations of selenium, copper, and zinc in neonatal foals: Influence of failure of passive transfer and age-related changes.
The Canadian veterinary journal = La revue veterinaire canadienne    May 2, 2024   Volume 65, Issue 5 481-487 
Stahl LT, Mu00fcller A, Krohn J, Bu00fcttner K, Wehrend A.An adequate supply of trace elements is very important for equine neonates, as deficiencies can lead to health problems and even death. Unassigned: This study investigated serum concentrations of selenium (Se), copper (Cu), and zinc (Zn) in neonatal foals up to the 8th day of life. The influences of disease, age, and failure of passive transfer (FPT) on these concentrations were analyzed. Unassigned: Serum concentrations of Se, Cu, and Zn were determined from blood samples of 93 foals by means of inductively coupled plasma mass spectrometry. The foals were divided into 2 groups based on health...
Proximity tracking using ultra-wideband technology for equine social behaviour research.
Scientific reports    April 30, 2024   Volume 14, Issue 1 9971 doi: 10.1038/s41598-024-60805-0
Torres Borda L, Roth P, Lumetzberger J, Auer U, Jenner F.Sociopositive interactions with conspecifics are essential for equine welfare and quality of life. This study aimed to validate the use of wearable ultra-wideband (UWB) technology to quantify the spatial relationships and dynamics of social behaviour in horses by continuous (1/s) measurement of interindividual distances. After testing the UWB devices' spatiotemporal accuracy in a static environment, the UWB measurement validity, feasibility and utility under dynamic field conditions was assessed in a group of 8 horses. Comparison of the proximity measurements with video surveillance data estab...
Effect of hospitalization on equine local intestinal immunoglobulin A (IgA) concentration measured in feces.
Journal of equine veterinary science    April 30, 2024   105078 doi: 10.1016/j.jevs.2024.105078
May A, Gerhards H, Wollanke B.During hospitalization horses may develop gastrointestinal conditions triggered by a stress-associated weak local immune system. The prospective, clinical trial was conducted to find out whether fecal immunoglobulin A (IgA) concentrations could be determined in hospitalized horses and how they changed during hospitalization and in response to various stressors. Samples were obtained from 110 horses and a control group (n = 14). At arrival in the hospital, horses were categorized into pain grades (1-5), and elective versus strenuous surgery (> 2 hours, traumatic and emergency procedures)...
Occurrence of ultrasonographic assessed placental abnormalities, treatments, pregnancy outcome, and subsequent fertility on a large warmblood stud farm: a retrospective field study.
Journal of equine veterinary science    April 30, 2024   105076 doi: 10.1016/j.jevs.2024.105076
Sielhorst J, Koether K, Volkmann N, Blanco M, Vicioso R, Baade S, Kemper N, de Mestre AM, Sieme H.Little is known about the incidence and outcome of high-risk pregnancies in equine practice and clinical studies on spontaneous occurring placentitis cases and treatments are missing. Therefore, the aims of this retrospective field study were to (1) describe the incidence and severity of ultrasonographic assessed placental abnormalities (UPA) in 4,192 pregnancies on a large commercial warmblood stud farm in 2017 - 2019 and (2) characterize these UPA cases and their pregnancy outcome. UPA severity (Placental abnormality score (PSc) 1-3; low to high), nine treatment regimens (TM1-9) used in UPA ...
COVID-19 effects on horses in-transition: A survey analysis of United States equine industry perspectives.
Journal of equine veterinary science    April 29, 2024   105077 doi: 10.1016/j.jevs.2024.105077
Esterl-Byrne LL, Huseman CJ, Haynes C, Kinman LA, Jones TN.The welfare of unwanted horses presents a significant concern for the equine industry. However, there is a lack of research on how unwanted horses are affected by major crises. The drastic changes that resulted from the COVID-19 pandemic presented ample opportunity to investigate how unwanted horses are impacted by challenging circumstances. Study objectives were to evaluate the COVID-19 pandemic's impact on the unwanted horse population and determine the current perceptions of horses in-transition. A 23-question online survey designed using Qualtrics was administered electronically to adults ...
Practitioner Experiences of the Death of an Equine in an Equine-Assisted Services Program.
Omega    April 23, 2024   302228241249200 doi: 10.1177/00302228241249200
Nieforth LO, Kaufman S.Given the nature of horse-human interactions in equine-assisted services (EAS), death of a horse may have significant impacts. In this study, an online survey was distributed to EAS practitioners. The goal of the study was to explore the experiences of practitioners and identify the socioemotional processes that occur upon the death of an equine within an EAS program. Open-ended responses ( = 84) were analyzed qualitatively using a grounded theory and constant-comparative approach. Responses are situated into two themes (1) Processing the death of an equine and (2) Practical implications. Expe...
Green treasures: Investigating the biodiversity potential of equine yards through the presence and quality of landscape features in the Netherlands.
PloS one    April 11, 2024   Volume 19, Issue 4 e0301168 doi: 10.1371/journal.pone.0301168
Wolframm IA, Heric L, Allen AM.At a time of mounting ecological crises and biodiversity loss, there is an urgent need for nature-based solutions. Equestrian properties cover a considerable proportion of the European rural and peri-urban landscape and provide much potential for integrating ecosystem services, such as the inclusion of small landscape features. The aim of this study was to investigate the presence and quality of landscape features (LF) to help determine how the equine sector can contribute to the agro-ecological transition. Using a citizen science approach, 87 commercial and 420 private yard owners reported th...
The Role of an Equine Nutritionist in Equine Health, Performance and Wellbeing: Ideas stemming from an Equine Science Society Symposium Workshop.
Journal of equine veterinary science    March 15, 2024   105047 doi: 10.1016/j.jevs.2024.105047
Pratt-Phillips SE, Liburt NR.In the United States, there is little clarity on the qualifications and availability of equine nutritionists. Currently, no regulatory body exists for formal credentialing outside of veterinary medicine. Most equine nutritionists are not veterinarians but do have advanced scientific degrees (Master of Science and/or Doctor of Philosophy) in the field of Animal Science. However, not all reporting to be equine nutritionists have formal education in the field of equine nutrition. To discuss this, a workshop was held at the 2023 Equine Science Society (ESS) meeting. The purpose of this discussion ...
Characterization of extracellular trap production and release by equine neutrophils in response to different stimuli.
Developmental and comparative immunology    February 28, 2024   Volume 155 105151 doi: 10.1016/j.dci.2024.105151
Quiroga J, Cortes B, Sarmiento J, Moru00e1n G, Henru00edquez C.This study explores Neutrophil Extracellular Trap (NET) formation in equine neutrophils, which is crucial for eliminating infections and is implicated in various equine inflammatory diseases. We investigated the molecular pathways involved in NET release by equine neutrophils in response to stimuli. We use PMA, A23187, LPS, PAF, OZ, and cytokines, observing NET release in response to PMA, PAF, and A23187. In contrast, LPS, OZ, and the cytokines tested did not induce DNA release or did not consistently induce citrullination of histone 4. Peptidyl-arginine deiminase inhibition completely halted ...
Pulmonary aspergillosis in a horse: a case report.
Brazilian journal of veterinary medicine    January 9, 2024   Volume 46 e004723 doi: 10.29374/2527-2179.bjvm004723
Melo UP, Ferreira C, Barreto SWM.Respiratory diseases considerably affect equine athletes, being the second most common cause of poor performance. Among these diseases, fungal pneumonia in horses, caused specifically by spp., is relatively rare but potentially fatal. Fungal pneumonia typically affects horses exposed to fungal elements due to environmental factors, immunosuppression, or previous debilitating illnesses. Treatment is complex, with minimal success due to late diagnosis and serious concomitant underlying diseases. The choice of medication depends on the site of infection, the fungal species involved, and financia...
Recent sequencing and phylogenetic analysis of equine herpesviruses 1 and 4 among different equine populations in Egypt.
Journal of advanced veterinary and animal research    December 31, 2023   Volume 10, Issue 4 639-646 doi: 10.5455/javar.2023.j719
El-Zayat M, Shemies OA, Mosad SM, El Rahman SA.Equine herpes viruses (EHVs) are considered one of the most important respiratory pathogens in equids, resulting in serious outcomes for equine health worldwide. The objectives of the current research were the detection, molecular characterization, and isolation of EHV-1 and EHV-4 circulating within different equine populations in Egypt, either clinically or in apparently healthy horses. Unassigned: A total of 120 field samples were collected, and DNA was extracted. Screening and typing of extracted DNA were done by consensus and conventional PCR assays for detection of EHV-1 and EHV-4, follow...
Digitalisation in pre-purchase examination and prospects for an equine health database in Germany-Results of an online survey among equine veterinarians.
Equine veterinary journal    September 12, 2023   doi: 10.1111/evj.14001
Folgmann MS, Kleinsorgen C, Stock KF, Meister D, Hellige M, Feige K, Delling U.Digital recording and storage of health data are becoming increasingly important in the fields of both human and veterinary medicine. There is currently a lack of information on the level of digitalisation among equine veterinarians in Germany and their attitudes towards advanced digitalisation. Objective: To collect opinions of equine veterinarians about (1) digital data collection in pre-purchase examinations (PPEs), and (2) the establishment of an equine health database in Germany. Methods: Cross-sectional survey. Methods: An online survey was developed and distributed via email exclusively...
Molecular and Serological Survey of Severe Fever with Thrombocytopenia Syndrome Virus in Horses from the Republic of Korea.
Vector borne and zoonotic diseases (Larchmont, N.Y.)    September 8, 2023   doi: 10.1089/vbz.2022.0101
Han SW, Cho YK, Rim JM, Kang JG, Choi KS, Chae JS. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic tick-borne disease in East Asia caused by the SFTS virus (SFTSV). It is to investigate the presence of SFTSV RNA and antibodies in horses from a slaughterhouse and equestrian centers in the Republic of Korea (ROK). A prevalence study of SFTSV-specific RNA and antibodies was designed from 889 horses in the ROK. Serum samples were collected from horses at a slaughterhouse and equestrian centers from 2018 to 2020. To detect the presence of SFTSV, RNA was extracted from the serum samples, and a nested reverse transcriptio...
Allogeneic chondrogenic-induced mesenchymal stem cells for the treatment of tarsometatarsal lameness in horses.
Veterinary surgery : VS    September 8, 2023   doi: 10.1111/vsu.14030
Coomer RPC, Terschuur JA, Pressanto MC, Walker I.To assess the efficacy of commercial intra-articular blood-derived allogeneic-induced mesenchymal stem cells (CIMSCs) to treat tarsometatarsal lameness in horses. Methods: This was a retrospective cohort study. Methods: Records from 167 adult light breed horses with bilateral tarsometatarsal lameness. Methods: Horses with tarsometatarsal lameness were retrospectively selected from medical records. Diagnosis followed subjective graded lameness assessment before and after intra-articular analgesia, with graded radiographic tarsal examination. Horses were excluded if they were diagnosed or treate...
CANTERing towards more sustainable helminth control.
The Veterinary record    September 8, 2023   Volume 193, Issue 5 doi: 10.1002/vetr.3435
Colgate V.Victoria Colgate of Equine Infectious Disease Surveillance introduces CANTER, a voluntary pan-industry initiative that is aiming to inspire behaviour change among horse owners and promote a more sustainable approach to controlling parasites in their animals.
Longitudinal effects of oral administration of antimicrobial drugs on fecal microbiota of horses.
Journal of veterinary internal medicine    September 8, 2023   doi: 10.1111/jvim.16853
Gomez D, Toribio R, Caddey B, Costa M, Vijan S, Dembek K.Antimicrobial drug-associated diarrhea (AAD) is the most common adverse effect in horses receiving antimicrobials. Little information on how oral administration of antimicrobials alters intestinal microbiota in horses is available. Objective: Investigate changes of the fecal microbiota in response to oral administration of antimicrobials. Methods: Twenty healthy horses. Methods: Prospective, longitudinal study. Horses were randomly assigned to 4 groups comprising 4 horses each: group 1 (metronidazole); group 2 (erythromycin); group 3 (doxycycline); group 4 (sulfadiazine/trimethoprim, SMZ-TMP);...
Adaptation strategies of the Icelandic horse with induced forelimb lameness at walk, trot and tölt.
Equine veterinary journal    September 7, 2023   doi: 10.1111/evj.13998
Smit IH, Hernlund E, Persson-Sjodin E, Bju00f6rnsdu00f3ttir S, Gunnarsdottir H, Gunnarsson V, Rhodin M, Serra Braganca FM.Lameness assessment in the gaited Icelandic horse is complex. We aimed to describe their kinematic and temporal adaptation strategies in response to forelimb lameness at walk, trot and tölt. Methods: In vivo experiment. Methods: Ten clinically non-lame Icelandic horses were measured before and after reversible forelimb lameness induction. Upper body and limb kinematics were measured using 11 inertial measurement units mounted on the poll, withers, pelvis (tubera sacrale) and all four limbs and hoofs (Equimoves®, 500 Hz). Horses were measured on a straight line at walk and trot in-hand and ...
Comparison of oral esomeprazole and oral omeprazole in the treatment of equine squamous gastric disease.
Equine veterinary journal    September 7, 2023   doi: 10.1111/evj.13997
Sundra T, Gough S, Rossi G, Kelty E, Rendle D.Oral omeprazole is the accepted treatment for equine squamous gastric disease (ESGD); however, it is not universally effective. Esomeprazole results in more consistent and pronounced acid suppression in men and is more effective than omeprazole in the treatment of oesophageal and gastric disease. Pharmacodynamic and pilot clinical studies have indicated esomeprazole might also be more effective than omeprazole in horses. Objective: To compare the efficacy and safety of oral esomeprazole and omeprazole pastes in the treatment of ESGD and, where present, concurrent equine glandular gastric disea...
Plasma melatonin concentration during the early post-partum period in Thoroughbred mares and their foals.
Acta veterinaria Hungarica    September 6, 2023   doi: 10.1556/004.2023.00883
Gu00e1spu00e1rdy A, Gallagher G, Bartha B, Cseh S, Fekete SG, Somosku0151i B.The authors aimed to determine the plasma melatonin concentration in mares and their new-born foals in the early post-partum period. Blood samples were collected from the jugular vein of 53 mare-foal pairs within twelve hours after parturition. Plasma melatonin levels were measured by ELISA. The melatonin concentration, adjusted for the moment of parturition using a generalised linear model, was 34.58 pg mL-1 in mares. It was significantly lower (27.63 pg mL-1) in the new-born foals. However, the melatonin concentration declined differently by the end of the twelve hours, it decreased less in...
Advances in dental management in the equine geriatric patient: strategies for improved welfare.
Journal of the American Veterinary Medical Association    September 6, 2023   1-7 doi: 10.2460/javma.23.06.0350
du Toit N.Geriatric horses have a high prevalence of dental disease, which is a culmination of age-related dental changes and dental disease throughout the life of the horse that may have long-term consequences. Wear abnormalities, diastemata with periodontal disease, pulpitis and endodontic disease, infundibular caries, and equine odontoclastic tooth resorption and hypercementosis become more prevalent with age. Recognition of age-related dental disease at an early stage can help to treat and possibly preserve teeth for longer. With a natural decrease in masticatory efficiency, it is even more importan...
Detection of adeno-associated viral DNA in equine post-administration frozen blood and plasma samples after long-term storage.
Drug testing and analysis    September 6, 2023   doi: 10.1002/dta.3569
Maniego J, Pesko B, Habershon-Butcher J, Hincks P, Taylor P, Stewart G, Proudman C, Ryder E.Gene doping in horses is a threat to the fairness in sport and has serious implications for animal welfare. To investigate the effect of long-term storage on the detection of AAV in plasma and whole blood, samples from an administration study using an adeno-associated virus serotype 6 expressing green fluorescence protein (AAV6-GFP) were stored at -20°C for 8 months before analysis. The AAV vector was detected in stored plasma samples, following the same detection profile as the fresh plasma samples. The stored blood showed lower overall DNA detection but followed the same detection profile ...
Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury.
American journal of veterinary research    September 6, 2023   1-8 doi: 10.2460/ajvr.23.07.0154
Koch DW, Schnabel LV.Tendon injuries are common in both veterinary and human clinical patients and result in morbidity, pain, and lost athletic performance. Consequently, utilizing naturally occurring injuries in veterinary patients as a comparative model could inform the development of novel therapies and increase translation for the treatment of human tendon injuries. Mesenchymal stem cells (MSCs) have shown considerable efficacy for the treatment of experimental and clinical superficial digital flexor tendon injury in the horse; however, the reinjury rate following treatment can remain high and MSC efficacy in ...
Fine-scale collective movements reveal present, past and future dynamics of a multilevel society in Przewalski’s horses.
Nature communications    September 5, 2023   Volume 14, Issue 1 5096 doi: 10.1038/s41467-023-40523-3
Studying animal societies needs detailed observation of many individuals, but technological advances offer new opportunities in this field. Here, we present a state-of-the-art drone observation of a multilevel herd of Przewalski's horses, consisting of harems (one-male, multifemale groups). We track, in high spatio-temporal resolution, the movements of 238 individually identified horses on drone videos, and combine movement analyses with demographic data from two decades of population monitoring. Analysis of collective movements reveals how the structure of the herd's social network is related...
Comparison of the broncoalveolar lavage fluid proteomics between foals and adult horses.
PloS one    September 5, 2023   Volume 18, Issue 9 e0290778 doi: 10.1371/journal.pone.0290778
Rivolta AA, Bujold AR, Wilmarth PA, Phinney BS, Navelski JP, Horohov DW, Sanz MG.Neonates have different cellular composition in their bronchoalveolar lavage fluid (BALF) when compared to foals and adult horses; however, little is known about the non-cellular components of BALF. The objective of this study was to determine the proteomic composition of BALF in neonatal horses and to compare it to that of foals and adult horses. Bronchoalveolar lavage fluid samples of seven neonates (< 1 week age), four 5 to 7-week-old foals, and six adult horses were collected. Quantitative proteomics of the fluid was performed using tandem mass tag labeling followed by high resolution l...
Sepsis-induced cardiomyopathy in animals: From experimental studies to echocardiography-based clinical research.
The Canadian veterinary journal = La revue veterinaire canadienne    September 4, 2023   Volume 64, Issue 9 871-877 
Naseri A, Akyuz E, Turgut K, Guzelbektes H, Sen I.The term "sepsis-induced cardiomyopathy" (SIC) is used to describe transient cardiac dysfunction in septic patients. However, there is no universally accepted definition of SIC; a reduction in left ventricular ejection fraction (LVEF) is often used. In addition to systolic dysfunction, diastolic dysfunction is now recognized as an essential component of SIC. It can be emphasized that previous animal experiments played an essential role in revealing SIC and hemodynamic instability in sepsis and septic shock. The diagnostic and prognostic capabilities of echocardiography for the assessment of SI...
Unilateral right mammary gland enlargement in a multiparous, pregnant 14-year-old American Quarter Horse mare.
Journal of the American Veterinary Medical Association    September 4, 2023   1-2 doi: 10.2460/javma.23.08.0459
Castillo J, Hilburger L, Rosenberg L, Cheong SH, Duhamel GE, de Amorim MD.No abstract available
Visualizing neutrophil extracellular traps in septic equine synovial and peritoneal fluid samples using immunofluorescence microscopy. Birckhead EM, Das S, Tidd N, Raidal SL, Raidal SR.Septic synovitis and peritonitis are routinely diagnosed in horses based on clinical examination findings and laboratory assessment of synoviocentesis and abdominocentesis samples, respectively. Diagnosis is difficult in some cases because of an overlap in laboratory results for septic and non-septic inflammation. Neutrophil extracellular trap (NET) formation is part of the innate immune response against pathogens. Identifying and quantifying NETs, which have not been explored in clinical samples from horses with septic synovitis and peritonitis, to our knowledge, may be helpful in detecting i...
1 2 3 1,946