Topic:Veterinary Medicine

Effect of storage conditions on the quality of equine and canine mesenchymal stem cell derived nanoparticles including extracellular vesicles for research and therapy.
Discover nano    May 3, 2024   Volume 19, Issue 1 80 doi: 10.1186/s11671-024-04026-4
Klymiuk MC, Balz N, Elashry MI, Wenisch S, Arnhold S.Nanoparticles including extracellular vesicles derived from mesenchymal stem cells are of increasing interest for research and clinical use in regenerative medicine. Extracellular vesicles (EVs), including also previously named exosomes, provide a promising cell-free tool for therapeutic applications, which is probably a safer approach to achieve sufficient healing. Storage of EVs may be necessary for clinical applications as well as for further experiments, as the preparation is sometimes laborious and larger quantities tend to be gained. For this purpose, nanoparticles were obtained from mes...
Is it pain, or is it behaviour?
The Veterinary record    May 3, 2024   Volume 194 Suppl 1 9 doi: 10.1002/vetr.4204
Pearson G.This year BVA Live will, for the first time, feature farm animal and equine CPD. Among the varied topics on offer, Gemma Pearson will be presenting an introduction to equine behavioural medicine, examining the link between emotional and physical health in horses.
Occurrence of ultrasonographic assessed placental abnormalities, treatments, pregnancy outcome, and subsequent fertility on a large warmblood stud farm: a retrospective field study.
Journal of equine veterinary science    April 30, 2024   105076 doi: 10.1016/j.jevs.2024.105076
Sielhorst J, Koether K, Volkmann N, Blanco M, Vicioso R, Baade S, Kemper N, de Mestre AM, Sieme H.Little is known about the incidence and outcome of high-risk pregnancies in equine practice and clinical studies on spontaneous occurring placentitis cases and treatments are missing. Therefore, the aims of this retrospective field study were to (1) describe the incidence and severity of ultrasonographic assessed placental abnormalities (UPA) in 4,192 pregnancies on a large commercial warmblood stud farm in 2017 - 2019 and (2) characterize these UPA cases and their pregnancy outcome. UPA severity (Placental abnormality score (PSc) 1-3; low to high), nine treatment regimens (TM1-9) used in UPA ...
COVID-19 effects on horses in-transition: A survey analysis of United States equine industry perspectives.
Journal of equine veterinary science    April 29, 2024   105077 doi: 10.1016/j.jevs.2024.105077
Esterl-Byrne LL, Huseman CJ, Haynes C, Kinman LA, Jones TN.The welfare of unwanted horses presents a significant concern for the equine industry. However, there is a lack of research on how unwanted horses are affected by major crises. The drastic changes that resulted from the COVID-19 pandemic presented ample opportunity to investigate how unwanted horses are impacted by challenging circumstances. Study objectives were to evaluate the COVID-19 pandemic's impact on the unwanted horse population and determine the current perceptions of horses in-transition. A 23-question online survey designed using Qualtrics was administered electronically to adults ...
Practitioner Experiences of the Death of an Equine in an Equine-Assisted Services Program.
Omega    April 23, 2024   302228241249200 doi: 10.1177/00302228241249200
Nieforth LO, Kaufman S.Given the nature of horse-human interactions in equine-assisted services (EAS), death of a horse may have significant impacts. In this study, an online survey was distributed to EAS practitioners. The goal of the study was to explore the experiences of practitioners and identify the socioemotional processes that occur upon the death of an equine within an EAS program. Open-ended responses ( = 84) were analyzed qualitatively using a grounded theory and constant-comparative approach. Responses are situated into two themes (1) Processing the death of an equine and (2) Practical implications. Expe...
Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse: case report and literature review of cholangiocarcinoma in horses. Barrantes Murillo DF, Cattley RC, Cullen JM, Withers C, Towns J, Pfeifle R, Wooldridge A, Neto RLALT.A 17-y-old Arabian mare was presented to the Auburn Large Animal Veterinary Teaching Hospital with a long-term history of intermittent mild recurrent colic that responded to medical treatment. CBC revealed mild lymphopenia; serum biochemistry findings were of increased gamma-glutamyl transferase and creatine kinase activities, hyperferremia, hyperglycemia, hypomagnesemia, and hypokalemia. Abdominocentesis was compatible with low-protein transudate. Due to the progression and duration of clinical signs, the owner elected euthanasia. Postmortem examination and histopathology confirmed a cholangi...
Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study.
Comparative immunology, microbiology and infectious diseases    April 17, 2024   Volume 109 102185 doi: 10.1016/j.cimid.2024.102185
To evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test methods, were performed. Out of 628 bacteriological examinations, 2.5% resulted positive for strain...
Editorial: Electroencephalography and other neuroelectrophysiologic studies in post-MRI generation veterinary medicine.
Frontiers in veterinary science    April 9, 2024   Volume 11 1396967 doi: 10.3389/fvets.2024.1396967
James FMK, Wrzosek M, Hasegawa D.No abstract available
Application of the HRE-S to 140 horses with trigeminal-mediated headshaking and the association of clinical signs with diagnosis, therapy, and outcome.
Frontiers in veterinary science    April 5, 2024   Volume 11 1329054 doi: 10.3389/fvets.2024.1329054
Kloock T, Hellige M, Kloock A, Feige K, Niebuhr T.Horses with trigeminal-mediated headshaking (TMHS) exhibit different headshaking patterns (HSPs), electric shock-like jerking, signs of nasal irritation, and painful facial expressions. The History Rest and Exercise Score (HRE-S) was developed to objectively clarify the severity of the condition in affected horses. This score considers the history and severity of clinical signs at rest and exercise. This study aimed to assess the frequency of different clinical signs and their individual associations with diagnosis, treatment, and outcome in horses diagnosed with TMHS.The clinical records of h...
Gross, organoleptic and histologic assessment of cadaveric equine heads preserved using chemical methods for veterinary surgical teaching.
Journal of veterinary science    April 3, 2024   Volume 25, Issue 2 e29 doi: 10.4142/jvs.23176
Romero Corru00eaa R, Peres Mendes R, Darley Velasquez Piu00f1eros D, De Lima AE, do Valle De Zoppa AL, Lopes Correia da Silva LC....Preservation of biological tissues has been used since ancient times. Regardless of the method employed, tissue preservation is thought to be a vital step in veterinary surgery teaching and learning. Objective: This study was designed to determine the usability of chemically preserved cadaveric equine heads for surgical teaching in veterinary medicine. Methods: Six cadaveric equine heads were collected immediately after death or euthanasia and frozen until fixation. Fixation was achieved by using a hypertonic solution consisting of sodium chloride, sodium nitrite and sodium nitrate, and an alc...
The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses.
Frontiers in pain research (Lausanne, Switzerland)    March 20, 2024   Volume 5 1373759 doi: 10.3389/fpain.2024.1373759
Reed RA, Berghaus LJ, Reynolds RM, Holmes BT, Krikorian AM, Sakai DM, Ishikawa Y, Knych HK.Understanding the pharmacokinetics and pharmacodynamics of fentanyl in horses is crucial for optimizing pain management strategies in veterinary medicine. Unassigned: Six adult horses were enrolled in a randomized crossover design. Treatments included: placebo, two 100 mcg/h patches (LDF), four 100 mcg/h patches (MDF), and six 100 mcg/h patches (HDF). Patches were in place for 72 h. Blood was obtained for fentanyl plasma concentration determination, thermal threshold, mechanical threshold, heart rate, respiratory rate, and rectal temperature were obtained prior patch placement and at m...
The Role of an Equine Nutritionist in Equine Health, Performance and Wellbeing: Ideas stemming from an Equine Science Society Symposium Workshop.
Journal of equine veterinary science    March 15, 2024   105047 doi: 10.1016/j.jevs.2024.105047
Pratt-Phillips SE, Liburt NR.In the United States, there is little clarity on the qualifications and availability of equine nutritionists. Currently, no regulatory body exists for formal credentialing outside of veterinary medicine. Most equine nutritionists are not veterinarians but do have advanced scientific degrees (Master of Science and/or Doctor of Philosophy) in the field of Animal Science. However, not all reporting to be equine nutritionists have formal education in the field of equine nutrition. To discuss this, a workshop was held at the 2023 Equine Science Society (ESS) meeting. The purpose of this discussion ...
The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses.
Journal of veterinary pharmacology and therapeutics    February 9, 2024   doi: 10.1111/jvp.13430
Bello K, Lorch G, Papich MG, Kim K, Toribio RE, Yan L, Xie Z, Hill K, Phelps MA.Additional immunomodulatory treatment is needed for the management of immune-mediated disease in horses. Mycophenolate mofetil (MMF) is an immunomodulatory agent used in human and veterinary medicine for the prevention of graft rejection and the management of autoimmune diseases. Few studies exist investigating the pharmacokinetics of MMF in horses. The aim of this study was to evaluate the pharmacokinetics of a single dose of MMF in healthy horses in the fed vs. fasted state. Six healthy Standardbred mares were administered MMF 10 mg/kg by a nasogastric (NG) tube in a fed and fasted state. ...
Trodusquemine (MSI-1436) Restores Metabolic Flexibility and Mitochondrial Dynamics in Insulin-Resistant Equine Hepatic Progenitor Cells (HPCs).
Cells    January 14, 2024   Volume 13, Issue 2 152 doi: 10.3390/cells13020152
Qasem B, Du0105browska A, Kru00f3liczewski J, u0141yczko J, Marycz K.Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There is increasing interest in utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown promising results in inhibiting protein tyrosine phosphatase (PTP1B) to maintain cell function in various models. In this study, we investigated the effects of the inhibitor Trodusquemine (MSI-1436) on equine hepatic progenitor cells (HPCs) under lipotoxic conditions. We examined proliferative activity, glucose uptake, and mitochondrial morphogenesi...
Diagnostic accuracy of plain radiography to identify synovial penetration in horses with traumatic limb wounds.
Equine veterinary journal    January 10, 2024   doi: 10.1111/evj.14050
Michotte M, Raes E, Oosterlinck M.The diagnostic value of plain radiography for diagnosing synovial penetration in limb wounds near synovial structures has not been determined. Objective: To assess diagnostic accuracy of plain radiography to identify synovial penetration in horses with traumatic limb wounds. Methods: Retrospective case study. Methods: Case records of horses presented to the Faculty of Veterinary Medicine of Ghent University (2011-2021) with limb wounds near synovial structures were categorised in groups with and without synovial penetration using results of synovial fluid analysis and surgical findings. Plain ...
Behavioral observations, heart rate and cortisol monitoring in horses following multiple oral administrations of a cannabidiol containing paste (part 2/2).
Frontiers in veterinary science    January 3, 2024   Volume 10 1305873 doi: 10.3389/fvets.2023.1305873
Eichler F, Ehrle A, Machnik M, Jensen KC, Wagner S, Baudisch N, Bolk J, Pu00f6tzsch M, Thevis M, Bu00e4umer W, Lischer C, Wiegard M.As a remedy against stress and anxiety, cannabidiol (CBD) products are of increasing interest in veterinary medicine. Limited data is available describing the actual effectiveness of CBD in horses. The aim of this study (part 2 of 2) was to analyze stress parameters via behavioral observation, heart rate monitoring and assessment of blood and saliva cortisol levels in healthy horses treated repeatedly with a CBD containing paste. Twelve horses were randomly assigned to a treatment or a control group. Two pastes were orally administered in a double-blinded study design, one paste containing CBD...
Investigative and Diagnostic Toxicology and Feed-Related Outbreaks.
The Veterinary clinics of North America. Equine practice    December 26, 2023   S0749-0739(23)00076-7 doi: 10.1016/j.cveq.2023.12.001
Hooser SB.Incidences of feed contamination are rare even though enormous amounts of animal feed are manufactured. However, there are still some cases of feed-related illness in horses. Veterinarians play a crucial role in recognizing and mitigating these events and in assessing the severity of risks. Due to these risks, proper reporting and consultation with government and state agencies are crucial. Accurate diagnosis and identification of the source of poisoning are promising when a thorough case workup is performed and agencies such as veterinary diagnostic laboratories and the US Food and Drug Admin...
Procalcitonin and carbonylated protein concentrations in equine synovial fluid.
Veterinary research communications    December 21, 2023   doi: 10.1007/s11259-023-10280-1
Nocera I, Sgorbini M, Meucci V, Gracia-Calvo LA, Tapio H, Camisi M, Sala G, Citi S.Early diagnosis of joint diseases is fundamental for prompt and appropriate management, particularly in septic arthritis. Procalcitonin (PCT) and protein carbonylated content (PCC) have been investigated in both human and veterinary medicine. An increase in PCT has been shown in infectious bacterial diseases, while higher levels of PCC have been shown in inflammatory pathologies characterized by oxidative damage. This study evaluated PCT and PCC in plasma and synovial fluid (SF), in healthy and pathological equine joints, affected by different types of arthropathy. Twenty-nine joints were eval...
Efficacy of treatment of equine anhidrosis with acupuncture and Chinese herbs is low but higher in treated horses compared with placebo.
Journal of the American Veterinary Medical Association    December 6, 2023   1-6 doi: 10.2460/javma.23.08.0474
Mallicote MF, Medina CI, Xie H, Zilberschtein J, Atria S, Manzie M, Hernandez JA, MacKay RJ.To assess the therapeutic efficacy of acupuncture in combination with Chinese herbs for treatment of horses affected with anhidrosis. Methods: 44 horses affected with anhidrosis for up to 3 years' duration were enrolled. Inclusion required both compatible clinical signs and results of a quantitative intradermal terbutaline sweat test. Methods: Study horses were randomly allocated into 2 groups. Group 1 (n = 19) was treated with daily Chinese herbs and 4 weekly acupuncture sessions. Group 2 (n = 25) was given daily hay powder as a placebo and 4 weekly sham acupuncture sessions. Horses were test...
Socio-Technical Analysis of the Benefits and Barriers to Using a Digital Representation of the Global Horse Population in Equine Veterinary Medicine.
Animals : an open access journal from MDPI    November 17, 2023   Volume 13, Issue 22 3557 doi: 10.3390/ani13223557
Sterkenburgh TR, Villalba-Diez J, Ordieres-Meru00e9 J.There is a consensus that future medicine will benefit from a comprehensive analysis of harmonized, interconnected, and interoperable health data. These data can originate from a variety of sources. In particular, data from veterinary diagnostics and the monitoring of health-related life parameters using the Internet of Medical Things are considered here. To foster the usage of collected data in this way, not only do technical aspects need to be addressed but so do organizational ones, and to this end, a socio-technical matrix is first presented that complements the literature. It is used in a...
Analytical Validation of MINI-PET as Point-of-Care for Erythrocyte Sedimentation Rate Measure in Horses.
Veterinary medicine international    November 15, 2023   Volume 2023 9965095 doi: 10.1155/2023/9965095
Pieroni C, Grassi A, Pantoli M, Berretti M, Messina S, Giovannini C, Lubas G, Diamanti D.The erythrocyte sedimentation rate (ESR) is a widely used diagnostic assay in human medicine but nowadays poorly applied in veterinary medicine. This test measures the speed (millimeters per hour) at which red blood cells settle in a whole anticoagulated blood tube. In human medicine, high ESR values are associated with various disorders, including infections, rheumatoid arthritis, oncologic diseases, and other inflammatory conditions. The ESR can also be influenced by some factors such as age and gender. In veterinary medicine, the ESR with the Westergren manual method was almost forgotten ov...
Pastern dermatitis outbreak associated with toxigenic and non-toxigenic Corynebacterium diphtheriae and non-toxigenic Corynebacterium ulcerans at a horse stable in Finland, 2021.
Zoonoses and public health    November 5, 2023   doi: 10.1111/zph.13090
Gru00f6nthal TSC, Lehto AK, Aarnio SS, Eskola EK, Aimo-Koivisto EM, Karlsson T, Koskinen HI, Barkoff AM, He Q, Lienemann T, Rimhanen-Finne R....Corynebacterium diphtheriae and Corynebacterium ulcerans, when producing toxin, are the cause of diphtheria, a potentially life-threatening illness in humans. Horses (Equus ferus caballus) are known to be susceptible to infection that may manifest clinically on rare occasions. In late 2021 and early 2022, specimens from five horses suffering from pastern dermatitis were cultured at the Laboratory of Clinical Microbiology at the Faculty of Veterinary Medicine, University of Helsinki, Finland. C. diphtheriae and/or C. ulcerans were recovered from all of these. This study aimed to (1) analyse the...
Analytical Validation of Two Assays for Equine Ceruloplasmin Ferroxidase Activity Assessment.
Veterinary sciences    October 18, 2023   Volume 10, Issue 10 623 doi: 10.3390/vetsci10100623
Cecchini Gualandi S, Di Palma T, Boni R.Ceruloplasmin (Cp) assessment in biological samples exploits the oxidase activity of this enzyme against several substrates, such as -phenylenediamine (-P), -dianisidine (-D) and, most recently, ammonium iron(II) sulfate (AIS). Once developed in humans, these assays are often used in veterinary medicine without appropriately optimizing in the animal species of interest. In this study, two assays using AIS and -D as substrates have been compared and validated for Cp oxidase activity assessment in horse's plasma. The optimization of the assays was performed mainly by varying the buffer pH as wel...
Evaluation of clinical and diagnostic imaging findings of bilateral superficial digital flexor tendon luxation in the tarsus of a gelding.
Veterinary research forum : an international quarterly journal    October 15, 2023   Volume 14, Issue 10 579-582 doi: 10.30466/vrf.2023.1989381.3780
Anoushepour A, Eftekhari S, Masoudifard M.Superficial digital flexor tendon (SDFT) plays an important role in the locomotion of the horses with flexion of the limbs. In the hind limb, it passes over the calcaneal bone and attaches to medial and lateral surfaces of calcaneous by two bands of connective tissue; while, the medial band is weaker than the lateral one. Occasionally, severe trauma, over-extension or fracture of the calcaneous may cause rupture of the supportive bands leading to tendon luxation. An 11-year-old Thoroughbred jumping gelding with symptoms of lameness in both legs, after examination by an internal specialist vete...
Environmental risk factors for UV-induced cutaneous neoplasia in horses: A GIS approach.
The Canadian veterinary journal = La revue veterinaire canadienne    October 2, 2023   Volume 64, Issue 10 971-975 
Ramirez M, Duncan C, Schaffer PA, Wobeser B, Magzamen S.Ultraviolet light (UV) is a risk factor for the development of cutaneous neoplasia in many mammalian species. This study evaluated UV exposure as a risk factor of concern for the development of cutaneous neoplasia in equine species due to the significant UV exposure that may accrue over their lifetimes. Neoplastic biopsy specimens from 3272 horses that were submitted over a 10-year period to the Colorado State University Diagnostic Medicine Center and to the University of Saskatchewan Western College of Veterinary Medicine and Prairie Diagnostic Services were evaluated. This retrospective stud...
Review of local extravascular delivery systems for chemotherapeutic agents in small animals and horses.
The Canadian veterinary journal = La revue veterinaire canadienne    October 2, 2023   Volume 64, Issue 10 957-967 doi: 10.1111/vsu.13506
Risselada M, Worth DB.Tumors of various sizes and locations can create a treatment dilemma in achieving adequate surgical margins when sufficient free tissue is not available for closure. Extravascular local adjunctive chemotherapy has been investigated clinically to aid in achieving local tumor control in animals with naturally occurring neoplastic disease. Local chemotherapy can be an alternative primary or a local adjunctive treatment. This is a summary of relevant findings of and studies on local chemotherapeutic delivery through carrier media, together with a summary of outcomes of clinical use of local deli...
Mesenchymal Stem Cells Isolated from Equine Hair Follicles Using a Method of Air-Liquid Interface.
Stem cell reviews and reports    September 21, 2023   Volume 19, Issue 8 2943-2956 doi: 10.1007/s12015-023-10619-w
Equine mesenchymal stem cells (MSC) of various origins have been identified in horses, including MSCs from the bone marrow and adipose tissue. However, these stem cell sources are highly invasive in sampling, which thereby limits their clinical application in equine veterinary medicine. This study presents a novel method using an air-liquid interface to isolate stem cells from the hair follicle outer root sheath of the equine forehead skin. These stem cells cultured herewith showed high proliferation and asumed MSC phenotype by expressing MSC positive biomarkers (CD29, CD44 CD90) while not e...
Non-invasive estimation of in vivo optical properties and hemodynamic parameters of domestic animals: a preliminary study on horses, dogs, and sheep.
Frontiers in veterinary science    September 18, 2023   Volume 10 1243325 doi: 10.3389/fvets.2023.1243325
Frabasile L, Amendola C, Buttafava M, Chincarini M, Contini D, Cozzi B, De Zani D, Guerri G, Lacerenza M, Minero M, Petrizzi L, Qiu L, Rabbogliatti V....Biosensors applied in veterinary medicine serve as a noninvasive method to determine the health status of animals and, indirectly, their level of welfare. Near infrared spectroscopy (NIRS) has been suggested as a technology with this application. This study presents preliminary time domain NIRS measurements of optical properties (absorption coefficient, reduced scattering coefficient, and differential pathlength factor) and hemodynamic parameters (concentration of oxygenated hemoglobin, deoxygenated hemoglobin, total hemoglobin, and tissue oxygen saturation) of tissue domestic animals, specif...
Digitalisation in pre-purchase examination and prospects for an equine health database in Germany-Results of an online survey among equine veterinarians.
Equine veterinary journal    September 12, 2023   doi: 10.1111/evj.14001
Folgmann MS, Kleinsorgen C, Stock KF, Meister D, Hellige M, Feige K, Delling U.Digital recording and storage of health data are becoming increasingly important in the fields of both human and veterinary medicine. There is currently a lack of information on the level of digitalisation among equine veterinarians in Germany and their attitudes towards advanced digitalisation. Objective: To collect opinions of equine veterinarians about (1) digital data collection in pre-purchase examinations (PPEs), and (2) the establishment of an equine health database in Germany. Methods: Cross-sectional survey. Methods: An online survey was developed and distributed via email exclusively...
Evidence of Horse Exposure to Anaplasma phagocytophilum, Borrelia burgdorferi, and Leishmania infantum in Greece through the Detection of IgG Antibodies in Serum and in an Alternative Diagnostic Sample-The Saliva.
Biomolecules    September 11, 2023   Volume 13, Issue 9 1374 doi: 10.3390/biom13091374
Athanasiou LV, Katsogiannou EG, Tyrnenopoulou P, Gougoulis D, Apostolidis KN, Papadakis SM, Kokkinaki KCG, Papatsiros VG, Tsokana CN.Among the various zoonotic pathogens that infect horses, spp. and spp. have gained scientific interest, and relevant molecular and serological studies in horses have been conducted worldwide. Moreover, human and veterinary medicine have extensively applied alternatives to serum diagnostic samples-such as saliva-for detecting pathogens or antibodies. In this study, we investigated the exposure of horses in Greece to , , and , and we assessed the diagnostic accuracy of saliva compared to serum in detecting IgG antibodies against the abovementioned pathogens. Paired saliva and serum samples wer...
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