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Frontiers in veterinary science.
Publisher:
Frontiers Media S.A.,
Country: Switzerland
Language: English
Start Year:2014 -
ISSN:
2297-1769 (Electronic)
2297-1769 (Linking)
2297-1769 (Linking)
Impact Factor
3.2
2022
| NLM ID: | 101666658 |
| (OCoLC): | 908319805 |
| LCCN: | 2015243350 |
| Classification: | W1 |
Antinociceptive effects of subcutaneous butorphanol administration in healthy horses. Subcutaneous (SQ) butorphanol administration maintains target plasma concentrations in horses longer than intravenous administration with fewer adverse effects. This study aimed to evaluate whether SQ butorphanol also produces clinically relevant antinociception in healthy horses. Unassigned: In a blinded, randomized, cross-over study, eight horses received 0.1 mg/kg butorphanol or equal volume (0.01 mL/kg) saline SQ in the cervical region. Thermal (TT) and pain pressure (PPT) thresholds at different body locations, along with physiological and behavioral variables, were assessed at baseli...
Evaluating a novel automatic feeding device for hay provision in horses: behavioral outcomes in group and individual housing. This study evaluated a novel Automatic Feeding Device (AFD) for hay provision in group-housed and individually housed horses. Unassigned: In Phase 1 (P1), behavioral responses to ground hay feeding (Control-Hay) and to hay delivery through the AFD were assessed in three group-housed mares under two conditions: AFD continuously open (O-AFD) and AFD alternating between open and closed periods (OC-AFD). In Phase 2 (P2), four individually housed horses were used to evaluate the behavioral effects of three AFD opening-closing schedules: long opening (LO-OP), medium opening (ME-OP), and short openin...
Pulled-up race outcomes as welfare-relevant surveillance indicators in United States Steeplechase horses, 2023-2025. Pulled-up race outcomes are routinely recorded but are nonspecific, potentially reflecting fatigue, poor performance, footing, rider judgment, suspected injury, or physiological compromise. We evaluated their association with subsequent participation disruption in United States steeplechase horses. Unassigned: National Steeplechase Association Race Results Reports from 2023 to 2025 were analyzed retrospectively at the horse-start level. Outcomes were time to the next later-date start, ≥60-day interruption, ≥183-day absence, and no recorded later-date start. Cox models were stratified by ra...
Changes in hoof morphology in racing Thoroughbreds during a period of ninety days unshod. Low hoof angles and discrepancies in the dorsal heel are linked to musculoskeletal breakdown, suspensory apparatus failure, and retirement in Thoroughbred racehorses. Evidence-based research on correcting hoof adaptations is limited, which leads to a reliance on therapeutic shoeing. Unassigned: This study aimed to test the hypothesis that morphological changes occur during active unshod training and that trimming immediately affects hoof angles. Unassigned: This is a controlled, quantitative, longitudinal study that uses a convenience sample. Unassigned: A total of 36 racehorses were divided i...
Behavioral changes in thoroughbred horses following pre-training: insights from novel object tests and activity monitoring under field conditions. Racehorse training starts with pre-training, which is conducted at a very early age and remains controversial from an animal welfare perspective. This study investigated how a 12-week pre-training program influenced the behavior of young Thoroughbred horses. Horses were assessed before (A) and after (B) pre-training, which progressed from habituation and handling to ridden exercise and canter work on a racetrack. Behavioral responses were evaluated using standardized novel object tests and continuous 24-h stall monitoring via inertial measurement unit sensors. Novel object test behavior was vi...
Correction: Sleep architecture and lying behavior in horses across age groups and two housing systems: an overnight non-invasive EEG study. [This corrects the article DOI: 10.3389/fvets.2026.1898580.].
Functional and biochemical inflammatory responses to a 75 ng intra-articular recombinant equine interleukin-1β (reIL-1β) synovitis model. Recently, a synovitis model using 75 ng intra-articular recombinant equine interleukin-1 (reIL 1β), showed promise for inducing a mild, self-limiting inflammatory response without overtly altering upper-body movement asymmetry in = 3 horses. This study aimed to evaluate the effect of this 75 ng reIL-1β model on gait biomechanics and synovial fluid (SF) inflammatory, pro-resolution, and cartilage turnover biomarkers in a larger equine sample. SF samples were collected from the left intercarpal joint of = 11 horses at baseline and at 6- and 12-hours following 75 ng reIL-1β injection and...
Proof of concept for low dose and delayed release of tigilanol tiglate in the treatment of equine sarcoids. Intra-tumoural administration of tigilanol tiglate has been shown effective in local treatment of cutaneous equine neoplasias. The drug causes rapid oncolysis and tumour slough, but may also be associated with comorbidities in sensitive and/or intricate anatomical sites due to its initial pro-inflammatory mode of action. Here we describe two approaches to optimise and further de-risk treatment of equine sarcoids with tigilanol tiglate, especially in difficult locations. Firstly, we provide preliminary clinical and observational data on the efficacy of low dose administration of tigilanol tigla...
Serum physiology, fecal microbiota, and metabolome signatures associated with perinatal stage transitions in Mongolian mares. Lactation is a critical reproductive trait that influences offspring survival and livestock productivity in equine production. Characterizing physiological transitions during the perinatal period can improve our understanding of how mares adapt to late gestation, parturition, and early lactation. However, in horses-a typical monogastric herbivore with unique digestive characteristics-the associations between gut microbiota and perinatal physiological adaptation, as well as related stage-associated microbial and metabolic features, remain largely uncharacterized. Unassigned: In this study, para...
Correction: Epidemiological study of strongyle infections in equines in Egypt: prevalence and risk factors. [This corrects the article DOI: 10.3389/fvets.2026.1901312.].
Non-coding RNA profiles associated with equine osteoarthritis: a systematic review. Non-coding RNAs (ncRNAs) play a role in the pathogenesis of osteoarthritis (OA) by regulating gene expression related to inflammation, chondrocyte apoptosis, and extracellular matrix degradation. In horses, OA is a leading cause of lameness and poor performance, with no current treatments halting disease progression and no clear biomarker available. Although some studies have investigated expression profiles of ncRNAs in equine OA, there is a need to systematically review previous efforts and synthesize information to identify potential ncRNAs to target in future research. Unassigned: The sear...
A color-coded atlas of the cortical surface anatomy of the equine brain. The horse has a highly gyrencephalic cerebrum; however, detailed references of equine cortical surface anatomy remain limited, and terminology inconsistencies continue to complicate comparative, clinical, and educational applications. This research focused on creating a standardized, high-resolution, color-coded atlas of equine brain sulci and gyri, based on the Nomina Anatomica Veterinaria (NAV). Unassigned: Brains from ten neurologically normal horses were examined. Following fixation and dissection, the sulci and gyri of the lateral, dorsal, rostral, and medial surfaces were documented, col...
Epidemiological study of strongyle infections in equines in Egypt: prevalence and risk factors. Equine strongylosis is one of the most prevalent gastrointestinal parasitic diseases affecting horses and donkeys worldwide, leading to reduced health, productivity, and working performance. This study aimed to determine the prevalence of gastrointestinal strongyle infection and identify associated risk factors among equines in three Egyptian governorates. Unassigned: A cross-sectional study was conducted on 540 horses and donkeys. Fresh fecal samples were collected and examined using the magnesium sulfate flotation technique for the detection of strongyle eggs. Associations between infection ...
Semi-extensive management system drives lower prevalence of equine orodental disorders. The prevalence of orodental disorders in horses kept under different management systems is lacking. More detailed knowledge is needed to support targeted therapeutic and prophylactic approaches, as these conditions play a crucial role in maintaining equine health and welfare. This study aimed to compare the prevalence of orodental disorders in horses raised, kept, and fed under extensive, semi-extensive, or intensive management systems. Unassigned: Sixty-nine clinically healthy adult crossbred horses with no history of dental treatment were examined, with 23 horses included in each study group...
The 3Fs as conditions of being: relational ontology and equine welfare in disaster response and reconciliation. Disaster relief work requires the collaboration of many stakeholders and can be viewed through a One Health lens, emphasising transdisciplinarity and an openness to different ways of knowing as well as an appreciation of the interdependence of human, animal, environmental health, and welfare. This perspective piece provides an autoethnographic account of a wildfire response in Western Canada in which a herd of free-ranging horses was rescued outside of conventional disaster management protocol. Through lived experience, the convergence between equine welfare, reconciliation, and relational ont...
Factors affecting veterinary perception of the prevalence of back pain and dysfunction in dogs and horses. The prevalence of back pain in humans has been extensively reported, but in dogs it is unknown. In horses, research on the prevalence of back pain exists, but with reports ranging from 1% to 94%, indicating a data deficiency. Unassigned: Veterinarians were surveyed about their perception of the prevalence of back pain and dysfunction in dogs and horses for 6 different clinical scenarios. The respondents' education background and physical examination techniques were recorded. Unassigned: Perceptions of the prevalence of back pain and dysfunction varied widely both within and between education g...
Cord blood mesenchymal stromal cells combined with hyaluronic acid show symptom-modifying and potential disease-modifying effects in an equine osteoarthritis fetlock chip model. Osteoarthritis (OA) is a major cause of lameness in horses, and current therapies largely address clinical signs rather than disease progression. Mesenchymal stromal cells (MSCs) have shown promise as disease-modifying biologics, but their effects on joint structure and immunologic phenotype remain incompletely characterized. Unassigned: To evaluate the safety and efficacy of pooled cryopreserved equine umbilical cord blood-derived MSCs (eCB-MSCs) combined with hyaluronic acid (HA) for surgically induced fetlock OA in horses, using integrated clinical, imaging, and synovial biomarker outcomes....
Sleep architecture and lying behavior in horses across age groups and two housing systems: an overnight non-invasive EEG study. Sleep is a crucial factor for the well-being of horses, yet assessing equine sleep in common housing conditions remains challenging. This study investigated the effects of changes in horses' immediate environment and the influence of age on their sleep and resting behavior using a novel, non-invasive electroencephalography (EEG) mask. Ten horses from the teaching herd at the University of Veterinary Medicine Vienna were observed over four consecutive nights in two different housing systems (a large communal stable vs. two separate, adjacent individual stalls). Data collection included EEG reco...
Cryopreserved umbilical allograft (equicenta® CTM) improves clinical outcomes compared with clinician-selected standard of care in performance horses: a pragmatic prospective controlled trial. This multicenter, prospective, controlled clinical study and client survey evaluated the safety and effectiveness of an equine umbilical tissue suspension (equicenta® CTM; eCTM, 2:1) compared with clinician-selected standard of care (SOC) for treating lame performance horses. Unassigned: This pragmatic, real-world, open-label study enrolled horses diagnosed with appendicular musculoskeletal conditions affecting the joints, tendons, or ligaments under owner consent and an intention-to-treat design with an optional crossover after no improvement at 12 weeks and per-protocol analyses at 26 ...
Penile and preputial pythiosis in Saudi Arabian horses: clinicopathological features and surgical outcomes. Pythiosis, caused by , is a chronic granulomatous disease of horses characterized by invasive, ulcerative, and pyogranulomatous cutaneous lesions. Involvement of the external genitalia is uncommon and remains poorly characterized, particularly regarding environmental exposure and treatment outcomes. This study aimed to describe the epidemiological pattern, clinicopathological features, diagnostic findings, and surgical outcomes of penile and preputial genital pythiosis in a hospital-presented horse cohort. Unassigned: A retrospective study was conducted on 123 horses presented with cutaneous u...
Prevalence of equine lungworm (Dictyocaulus arnfieldi) infection and associated risk factors in Egypt. infection is a common parasitic respiratory disease of equines that can adversely affect animal health, welfare, and productivity. However, epidemiological information on this infection remains limited in many regions of Egypt. This study aimed to determine the prevalence of and identify associated risk factors among equines in three Egyptian governorates. Unassigned: A cross-sectional study was conducted on 415 equines, including 150 donkeys, 55 mules, and 210 horses. Animals were examined for , and data on species, age, body condition, and deworming history were collected. Associations bet...
Canagliflozin treatment of a horse with hyperinsulinemia, including pharmacokinetic analysis of different dosing protocols: a case report. Laminitis is a complex and painful disease of the equine foot. Insulin dysregulation (ID) resulting in hyperinsulinemia is responsible for more than 90% of cases in the general horse and pony population. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a relatively new class of drug that has gained considerable popularity as an off-label treatment of hyperinsulinemia-associated laminitis (HAL) in horses when traditional management changes and treatments are unsuccessful. In Canada, canagliflozin is the SGLT2i most available to equine veterinarians; although no dosing protocols have been ...
Reference interval for serum amyloid a in apparently healthy donkeys measured with a donkey-specific ELISA. Serum amyloid A (SAA) is a major acute phase protein used as an inflammatory biomarker in equine medicine. However, no universally accepted assay-specific reference interval (RI) exists for donkeys, and available literature remains limited, with only few studies using different donkey breeds and immunoassay platforms. This study aimed to establish an assay- and population-specific RI for serum SAA in apparently healthy donkeys using a species-specific double sandwich ELISA. Unassigned: Serum SAA concentrations were measured in 176 apparently healthy donkeys. RI estimation followed ASVCP/CLSI r...
Prevalence and radiographic features of cyst-like lesions in German Warmblood horses presented for pre-purchase examination. Cyst-like lesions (CLLs) are frequently detected during radiographic examinations of equine limbs. They may represent a potential risk factor during pre-purchase examination (PPE) and are of considerable clinical and economic importance, as they may lead to negative purchase decisions. While affected horses may develop lameness, incidental findings have also been reported. The goal of the study was to describe the prevalence, location and radiographic characteristics of CLLs in a group of sound German Warmblood horses. Unassigned: A retrospective cohort study was conducted on 3863 German Warmb...
Repeatability and test-retest reliability of thermal and pressure pain threshold testing in healthy thoroughbred horses. Quantitative sensory testing (QST) has been used in horses to assess nociceptive responsiveness but its broader clinical application is limited by variability across anatomical sites, environmental conditions, operator technique, and behavioral endpoints. This study aimed to evaluate the feasibility, within-session repeatability, and test-retest reliability of thermal threshold (TT) and pressure pain threshold (PPT) testing in healthy Thoroughbred horses. Unassigned: Eleven adult Thoroughbred horses (4 mares, 7 geldings; median [IQR] age 6 [5-6] years; body weight 558 ± 47 kg) underwent...
Correction: Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses. [This corrects the article DOI: 10.3389/fmed.2026.1810077.].
A point-based laminitis risk scoring system and machine learning framework for prediction of laminitis in horses. Laminitis is a painful and potentially life-threatening inflammatory condition of the equine hoof, and its detection remains a major challenge in veterinary practice. Although several risk factors have been reported, the prediction of the onset of laminitis in a subclinical stage using routine clinical data is still limited. This study aims to address this gap by developing an interpretable machine learning (ML) framework for the prediction of the risk of laminitis in horses. A point-based risk scoring system was first constructed using multivariate logistic regression to quantify the contribu...
Comparative clinical and thermographic responses to dexamethasone and saline solution mesotherapy in horses with spinal disorders. Back pain and spinal dysfunction in horses are multifactorial conditions frequently associated with musculoskeletal alterations that may impair mobility, performance, and welfare. Mesotherapy has emerged as a minimally invasive adjunctive approach for managing musculoskeletal disorders; however, comparative clinical responses to different intradermal protocols in equine spinal conditions remain insufficiently investigated. The present study aims to compare the clinical and thermographic responses of two mesotherapy protocols in horses diagnosed with cervical or thoracolumbar spinal disorders. ...
Dental disorders are associated with minimal synovial changes in the temporomandibular joint in horses. Dental disorders have been proposed as factors contributing to temporomandibular joint (TMJ) discomfort in horses, but objective evidence linking these conditions to synovial fluid alterations remains limited. This study evaluated whether the severity of dental abnormalities influences the physicochemical and cytological characteristics of TMJ synovial fluid and whether occlusal adjustment induces measurable synovial changes over time. Unassigned: Thirty-three horses were assigned to mild, moderate, or severe dental abnormality groups. Synovial fluid was collected bilaterally from the discotem...
Umbilical vein marsupialization in foals-short literature review. Umbilical remnant infections are common in neonatal foals and may involve one or more umbilical structures. Diagnosis relies on thorough clinical examination, ultrasonography, and hematologic evaluation. Standard care includes broad-spectrum antibiotics, with surgical resection if conservative therapy fails. Omphalophlebitis may extend to the liver, prompting consideration of umbilical vein marsupialization. Surgery is performed in dorsal recumbency with a fusiform incision around the umbilicus. The umbilical arteries and urachus are ligated and transected, with partial cystectomy when indicat...
