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Frontiers in veterinary science.

Periodical
Animal Diseases
Veterinary Medicine
Publisher:
Frontiers Media S.A.,
Country: Switzerland
Language: English
Start Year:2014 -
ISSN:
2297-1769 (Electronic)
2297-1769 (Linking)
Impact Factor
3.2
2022
NLM ID:101666658
(OCoLC):908319805
LCCN:2015243350
Classification:W1
Equine dental destructive disorders: an epidemiological survey in northern Germany.
Frontiers in veterinary science    February 17, 2026   Volume 13 1706621 doi: 10.3389/fvets.2026.1706621
Häussling MPP, Steinberg T, Büttner K, Hannig C, Hannig M, Lemke L, Zierau O, Staszyk C.Destructive lesions of the peripheral and infundibular cementum are increasingly recognized in equine dentistry. While similarities to human caries have been noted, current evidence does not conclusively support this classification. This study aims to assess the prevalence, distribution, and potential risk factors associated with these lesions in a defined horse population. Unassigned: A total of 114 horses from northern Germany underwent standardized oral examination between 2021 and 2023. Clinical data on peripheral and infundibular lesions, diastemata, and influencing factors such as age an...
Effects of a rehabilitative whole-body resistance band wrap on equine gait, posture, cortisol, and muscular function.
Frontiers in veterinary science    January 28, 2026   Volume 12 1738766 doi: 10.3389/fvets.2025.1738766
Boger B, Naraian M, Hernandez E, Eaton A, Rockburn R, Tillman I, Payne S, Yob C, Panek C, Manfredi JM.Resistance bands used while horses are exercised with their handlers have shown benefits, but it is unknown if whole-body resistance bands used independently have therapeutic benefits. This study hypothesized that horses with varying gait asymmetries would experience improvements in lameness, muscular function, range of motion, posture, and cortisol following short-term use of a whole-body resistance band wrap (RBW). In this study, nine lame adult horses were evaluated with and without the RBW. The assessment included: objective gait analysis, acoustic myography, postural analysis, gait kinema...
Biosecurity perspectives of equestrian competition organizers in Ontario, Canada.
Frontiers in veterinary science    January 23, 2026   Volume 12 1713303 doi: 10.3389/fvets.2025.1713303
Turcotte GK, O'Sullivan TL, Spence KL, Winder CB, Greer AL.Biosecurity plays an important role in the prevention and control of infectious disease outbreaks in the equine population. With competition organizers responsible for implementing and upholding biosecurity requirements at competitions, it is important to understand the biosecurity landscape at these locations where Ontario horses commonly travel and interact in large group settings. Unassigned: The objective of this study was to describe the perspectives, challenges and experiences of competition organizers of both sanctioned and unsanctioned events in Ontario, Canada regarding implementing e...
Case Report: Inhaled salbutamol in the successful treatment of life-threatening acute hyperkalaemia in an anaesthetised horse.
Frontiers in veterinary science    January 16, 2026   Volume 12 1663681 doi: 10.3389/fvets.2025.1663681
Rollet M, Flyps J, Vernemmen I, van Loon G, Schauvliege S.Hyperkalaemia is an uncommon complication of general anaesthesia in healthy horses. This case report describes the occurrence of life-threatening acute hyperkalaemia in a 13-year-old, female French Trotter anaesthetised for experimental right and left atrial 3D electro-anatomical mapping. Intra-operative development of hyperkalaemia (7.55 mmol/L) (Ref. 3.00-4.00 mmol/L) with atrial standstill on ECG necessitated transvenous ventricular pacing while initial treatment with insulin and glucose was initiated. Plasma potassium levels continued to increase (8.00 mmol/L) prompting adjunctive tr...
Functional and biochemical inflammatory responses to low-dose intra-articular recombinant equine IL-1β: a pilot study.
Frontiers in veterinary science    January 16, 2026   Volume 12 1746738 doi: 10.3389/fvets.2025.1746738
Korac L, St George L, MacNicol J, McCrae P, Jung L, Golestani N, Karrow N, Cánovas A, Pearson W.Low-dose intra-articular injection of recombinant equine interleukin-1β (reIL-1β) may offer a useful model for studying early onset or subclinical joint inflammation in horses. This pilot study aimed to determine the lowest intra-articular dose of reIL-1β required to produce biochemical evidence of synovitis, and to correlate synovitis biomarkers with functional, upper-body asymmetry parameters. Saline (control) and 50, and 75 ng reIL-1β were injected into the left or right intercarpal joint of three ( = 3) horses in a three-way crossover design. Synovial fluid was collected by aseptic art...
Characterization and priming of equine muscle-derived mesenchymal stem cells to enhance their anti-inflammatory and immunomodulatory profiles.
Frontiers in veterinary science    January 12, 2026   Volume 12 1741322 doi: 10.3389/fvets.2025.1741322
Shahid MA, Guitart AS, Bertin FR, Simon O, Ceusters J, Serteyn D, Whitworth DJ.A minimally invasive microbiopsy-based method for the isolation of mesenchymal stem cells (MSCs) from equine skeletal muscle (M-MSCs) provides a readily accessible source of MSCs for clinical applications. We examined the expression of genes associated with immunomodulation and anti-inflammatory pathways, in addition to those of growth factors and the major histocompatibility complex (MHC) molecules I and II, at constitutive levels and after priming with inflammatory cytokines, an immunostimulant, and heat-shocking. While there was notable variation between the M-MSCs from each of the horses i...
Clinical and laboratory evaluation in horses submitted to intracecal fluid therapy administered in two different rates.
Frontiers in veterinary science    January 12, 2026   Volume 12 1637033 doi: 10.3389/fvets.2025.1637033
Ventura Lopes Carvalho B, Neves de Souza MC, Souza Moreira N, Parisi Marliere J, Mesquita Mota JV, Drumond Bento L, de Castro Benitez A, Avanza MFB....Two routes of administration for electrolyte solutions are commonly used in horses with fluid, electrolyte, and acid-base imbalances: intravenous and nasogastric. Despite the frequent use of these routes, there are situations in which they cannot be applied. In such cases, intracecal fluid therapy represents a viable alternative, as this route enables the administration of enteral electrolyte solutions even in animals lacking normal anterior gastrointestinal function. This study aimed to evaluate the effects of a neutral hypotonic enteral electrolyte solution administered intracecally at two d...
Laparoscopically assisted cecal cannulation in standing horses.
Frontiers in veterinary science    January 9, 2026   Volume 12 1717140 doi: 10.3389/fvets.2025.1717140
Carvalho BVL, de Souza MCN, Avanza MFB, Teixeira RBC, Silva JRB, da Silva Cardoso T, Novais LGES, de Oliveira Monteiro FD, Viana RB, Monteiro BM....Access to the equine cecum is required for various therapeutic and experimental procedures, including decompression, fluid therapy, and transfaunation. Traditional approaches via laparotomy are highly invasive. This study aimed to describe a minimally invasive, laparoscopically assisted technique for cecal cannulation in standing horses. Unassigned: Seven horses underwent the procedure under sedation and paravertebral anesthesia. Two right flank accesses were created: a 10-mm laparoscopic port for visualization and a 2-cm minilaparotomy for cecal exteriorization. A Foley catheter was inserted ...
Omic technology to monitoring resilience and adaptation to exercise and heat stress in endurance horses.
Frontiers in veterinary science    January 9, 2026   Volume 12 1734969 doi: 10.3389/fvets.2025.1734969
In horses, heat exposure modulates the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and hypothalamic-pituitary-thyroid axis to maintain body temperature and prevent excessive heat accumulation. However, during strenuous exercise under hot and humid conditions, heat production may exceed dissipation, leading to heat stress, anhidrosis, heat stroke, or brain damage. Unassigned: Incremental field standardized exercise tests (fSETs) provide a reliable approach to assess training and fitness levels. Six Arabian horses from Italia Endurance Stable and Academy were monitored during ...
Extracorporeal shock wave therapy for equine musculoskeletal disorders: from biological mechanisms to clinical applications.
Frontiers in veterinary science    December 19, 2025   Volume 12 1719123 doi: 10.3389/fvets.2025.1719123
Qiu Z, Wang J, Zhang Y, Liu X, Wei C, Ma T.Musculoskeletal injuries represent a primary cause of suboptimal performance and early retirement in equine athletes. To address this challenge, the veterinary community has long endeavored to develop safer and more effective therapeutic strategies. Extracorporeal shock wave therapy (ESWT), as a treatment for equine musculoskeletal injuries, has garnered substantial attention among equine veterinarians. Focused on the theme ESWT Therapy for Equine Musculoskeletal Disorders: From biological mechanisms to clinical applications, this article systematically reviews existing literature on the biolo...
Metabolomic analysis of synovial fluid from healthy and pathological equine joints and tendon sheaths using high-resolution 1H Nuclear Magnetic Resonance.
Frontiers in veterinary science    December 16, 2025   Volume 12 1671176 doi: 10.3389/fvets.2025.1671176
Guadalupi M, Girelli CR, Della Tommasa S, Corte FD, Crovace AM, Fanizzi FP, Brehm W, Lacitignola L.Joint and tendon sheath diseases are a major cause of lameness and reduced performance in horses. Synovial fluid composition changes in response to pathological processes and metabolomic profiling offers a promising approach to detect these alterations. While equine joint metabolomics has been explored, little is known about the metabolomic profile of tendon sheaths. This study aimed to characterize and compare the synovial fluid metabolomic profiles of healthy and pathological joints and tendon sheaths in horses using high-resolution H Nuclear Magnetic Resonance spectroscopy, and to identify ...
Cyclooxygenase-2 and von Willebrand factor-an immunohistochemical study of the equine foot with and without laminitis, post-mortem perfused with paraffin oil.
Frontiers in veterinary science    December 15, 2025   Volume 12 1673415 doi: 10.3389/fvets.2025.1673415
Underberg BA, Van der Vekens E, Drews B, Kaessmeyer S.Equine laminitis is a complex and potentially fatal disease characterized by severe vascular and inflammatory alterations within the equine foot. This study aimed to develop immunohistochemistry (IHC) protocols for the detection of cyclooxygenase-2 (COX-2) and von Willebrand factor (vWF) in equine feet with and without laminitis, post-mortem perfused with paraffin oil. Unassigned: A total of 12 equine forelimbs from 8 horses were utilized in this study, divided into two study cohorts: one with laminitis and the other as a non-laminitis control. To develop the IHC protocols thoroughly, the tiss...
Correction: An anatomical study of the subarachnoid space surrounding the trigeminal ganglion in horses-in preparation for a controlled glycerol rhizotomy in equids.
Frontiers in veterinary science    December 15, 2025   Volume 12 1749889 doi: 10.3389/fvets.2025.1749889
Becker R, Haenssgen K, Precht C, Khoma OZ, Hlushchuk R, Koch C, Kaessmeyer S, de Preux M.[This corrects the article DOI: 10.3389/fvets.2024.1424890.].
Geographic diversity of the Streptococcus equi subsp. equi accessory genome: implications for vaccines and global surveillance.
Frontiers in veterinary science    November 28, 2025   Volume 12 1721958 doi: 10.3389/fvets.2025.1721958
He L, Khine NO, Song J, Loubière C, Butaye P.Strangles, caused by the host-adapted subsp. (. ), imposes significant welfare and economic losses on the equine industry worldwide. Understanding its genomic features, virulence-associated genes (VAGs), antimicrobial resistance (AMR) and mobile genetic elements (MGEs) is essential for disease control and vaccine development. This study aimed to characterize the accessory genome composition, geographic distribution of VAGs and MGEs, and AMR profiles of . by a large-scale genomic analysis of global publicly available . sequences. All publicly available . sequences in the Sequence Read Arch...
Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target.
Frontiers in veterinary science    November 28, 2025   Volume 12 1723160 doi: 10.3389/fvets.2025.1723160
Zamith Cunha R, Gobbo F, Morini M, Salamanca G, Zanoni A, Bernardini C, Gramenzi A, Chiocchetti R.Evidence suggests that the endocannabinoid system (ECS) is crucial for regulating inflammation, cell proliferation and pain. The ECS is composed of cannabinoid receptors such as type 1 (CBR1), type 2 (CBR2) and GPR55, endocannabinoids and enzymes. Proteins of ECS have previously been localized in the epidermal cells of the horse hooves. Given the physio-pathological role and cellular distribution of the ECS across species, the authors hypothesized that cannabinoid receptors are expressed within the inflammatory cells, fibroblasts and endothelial cells of the equine hoof laminae, going beyond t...
Equine-assisted learning and leadership transformation: an exploratory qualitative study of workplace behavior.
Frontiers in veterinary science    November 25, 2025   Volume 12 1700029 doi: 10.3389/fvets.2025.1700029
Sivagurunathan R, Senathirajah ARBS, Sivagurunathan L, Arokiasamy L, Qazi S, Haque R, Su Y.This study explores how equine-assisted leadership development (EALD) interventions activate experiential processes that reshape leaders' self-concept, relational schemas, and behaviors. A conceptual model is proposed to explain how non-verbal interaction with horses catalyzes transformational learning. Unassigned: A qualitative exploratory design was employed to examine leaders' experiences over 12 months following reintegration into their workplaces. Eight leaders ( = 8) attended a 5-day EALD program, engaging in "join-up" exercises with horses. Data were analyzed through reflexive the...
‘Pretty devastating’: exploring horse owner and veterinarian lived experiences of the equine Hendra virus.
Frontiers in veterinary science    November 21, 2025   Volume 12 1661615 doi: 10.3389/fvets.2025.1661615
White J, Thompson K, van den Berg D, O'Neill G, Mendez DH, Talwar J, Degeling C, Forsythe R, Durrheim DN.With more than 60% of emerging infectious diseases being zoonotic, we apply a One Health lens that connects human, animal, and environmental dimensions of the response to a Hendra virus (HeV) event. One Health promotes collaboration among health professionals, veterinarians, environmental scientists, and policymakers to strengthen health infrastructure and improve responses to complex health threats. HeV is an uncommon high-consequence and potentially fatal zoonotic disease endemic to parts of Australia. Previous research has largely focused on the uptake of preparedness measures by veterinari...
Correction: Integrated molecular and serological survey of Rhodococcus equi in horses from three regions of Kazakhstan.
Frontiers in veterinary science    November 17, 2025   Volume 12 1734084 doi: 10.3389/fvets.2025.1734084
Zanilabdin M, Ilgekbayeva G, Otarbayev B, Nissanova R, Mussayeva G, Takai S, Suzuki Y, Kakuda T, Kurman S, Kassymov Y, Valiyeva B.[This corrects the article DOI: 10.3389/fvets.2025.1650186.].
Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal.
Frontiers in veterinary science    November 13, 2025   Volume 12 1689782 doi: 10.3389/fvets.2025.1689782
Derar D, Ali A, Al-Sobayil F, Refaai W.Granulosa cell tumors (GCTs) represent the most common ovarian neoplasms in mares, yet data on their epidemiology, risk factors, and clinical outcomes in Arabian horses are limited. Understanding their prevalence and diagnostic features is crucial for improving fertility management in this breed. Unassigned: Clinical records from 807 Arabian mares housed on 35 stud farms in central Saudi Arabia were retrospectively reviewed to determine the prevalence of GCT and potential risk factors, including age, parity, and anabolic steroid use. Twenty-four confirmed cases were further investigated using ...
Metabolism, pharmacokinetics, and bioavailability of cannabigerol in horses following intravenous and oral administration with micellar and oil formulations.
Frontiers in veterinary science    October 29, 2025   Volume 12 1688214 doi: 10.3389/fvets.2025.1688214
Serrano-Rodríguez JM, Miraz R, Saitua A, Díez de Castro E, Ledesma-Escobar C, Ferreiro-Vera C, Priego-Capote F, Sánchez de Medina V....Cannabigerol (CBG) is a non-psychoactive cannabinoid with growing interest in veterinary medicine; however, its pharmacokinetic profile in horses remains unknown. Understanding its absorption, distribution, metabolism, and elimination is essential to optimizing dosing strategies and evaluating its potential for clinical use in equine patients. Unassigned: A prospective crossover study was conducted in eight healthy adult horses to assess the metabolism and the pharmacokinetics after intravenous (IV) administration at 1 mg/kg and oral administrations at 10 mg/kg with two formulations (mice...
Impact of sequential administration of detomidine, butorphanol, and midazolam on sedation, ataxia, stimulus response, and bispectral index in horses.
Frontiers in veterinary science    October 23, 2025   Volume 12 1691137 doi: 10.3389/fvets.2025.1691137
Thorn CA, Wilson DV, Wang S, Horne WA.Standing sedation is a safe and cost-effective alternative to general anesthesia in horses, but challenges include achieving adequate drug effect to block the stimulus response without inducing ataxia or recumbency. A benefit of midazolam has been reported in equine dental procedures. Seeking synergy, a combination of lower doses of several pharmacologic agents, including midazolam, may improve the quality of sedation while minimizing adverse effects. Bispectral index (BIS) correlates with sedation scores in human ICU patients, but the correlation between sedation scores and BIS has not been e...
Fetometry in Arabian horses.
Frontiers in veterinary science    October 23, 2025   Volume 12 1689769 doi: 10.3389/fvets.2025.1689769
Ali A, Derar DR, Alaeyeari AA, Alharbi YM.This study aimed to monitor intrauterine fetal growth, establish predictive equations for gestational age estimation, and determine the optimal period for fetal sexing in Arabian horses using ultrasonography. Unassigned: Seven Arabian mares were monitored from insemination to parturition using transrectal ultrasonography. The following fetal and embryonic parameters were measured: embryonic vesicle (EV), crown-rump length (CRL), biparietal diameter (BIP), stomach diameter (STD), chest depth (CHD), abdominal diameter (ABD), kidney length (KDL), eyeball diameter (EBD), and eye lens length (ELL)....
Equine adipose-derived stem cells modulate in vitro neutrophil extracellular trap release by polymorphonuclear neutrophils.
Frontiers in veterinary science    October 22, 2025   Volume 12 1685757 doi: 10.3389/fvets.2025.1685757
Salinas-Varas C, Espinosa G, Muñoz-Caro T, Conejeros I, Gärtner U, Fey K, Arnhold S, Taubert A, Hermosilla C.Neutrophil extracellular trap (NET) are thin and long web-like structures composed of DNA and antimicrobial proteins released by activated polymorphonuclear neutrophils (PMN) as part of the innate immune response. Adipose-derived stem cells (ADSCs) represent an accessible, abundant and minimal invasive source of mesenchymal stem cells (MSCs), with high regenerative potential, immunomodulatory and anti-inflammatory properties. Although recognized immunomodulatory properties of ADSCs, their interaction with PMN and their role on NET formation remains poorly characterized. The present study aimed...
Integrated molecular and serological survey of Rhodococcus equi in horses from three regions of Kazakhstan.
Frontiers in veterinary science    October 21, 2025   Volume 12 1650186 doi: 10.3389/fvets.2025.1650186
Zanilabdin M, Ilgekbayeva G, Otarbayev B, Nissanova R, Mussayeva G, Takai S, Suzuki Y, Kakuda T, Kurman S, Kassymov Y, Valiyeva B. is a facultative intracellular pathogen causing bronchopneumonia in foals; data from Central Asia are limited. We conducted a cross-sectional serological and molecular survey in horses from three regions of Kazakhstan (Kyzylorda, Almaty, Akmola). Unassigned: Sera from 312 animals (272 adults, 40 foals) on 20 farms were tested by indirect ELISA. Selected clinical samples underwent culture, PCR, and 16S rRNA sequencing. Unassigned: Overall seroprevalence was 8.3% (26/312; 95% CI 5.8-11.9). Positivity among foals was 25.0% (10/40; 95% CI 14.2-40.2) versus 5.9% (16/272; 95% CI 3.7-9.3) in adults,...
Correction: Prices for veterinary care of dogs, cats and horses in selected countries in Europe.
Frontiers in veterinary science    October 17, 2025   Volume 12 1694780 doi: 10.3389/fvets.2025.1694780
Egenvall A, Höglund OV, Hoffman R, Valle PS, Andersen PH, Lönnell C, Byström A, Bonnett BN.[This corrects the article DOI: 10.3389/fvets.2024.1403483.].
Editorial: Advances in the application of technology for monitoring horse welfare and health.
Frontiers in veterinary science    October 16, 2025   Volume 12 1715133 doi: 10.3389/fvets.2025.1715133
Dalla Costa E, Bovo M.Flowchart illustrating interdisciplinary collaboration in animal research. A horse symbolizes the focus, with pathways connecting physiology, behavior, and environment to decision-making and regulatory indications. Data analysis, system understanding, and data interpretation lead to feedback and warning. Visual elements include sun, clouds, a light bulb, gears, and a graph.
Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections.
Frontiers in veterinary science    October 15, 2025   Volume 12 1609955 doi: 10.3389/fvets.2025.1609955
Khalid E, Tartor YH, Ammar AM, Abdelaziz R, Mahmmod Y, Abdelkhalek A.Antimicrobial resistance is a major global health issue requiring a coordinated response. This study investigated for the first time the prevalence, antimicrobial resistance phenotypes of bacteria causing infections in Arabian horses, and the potential of bacteriophage therapy for wound treatment. One hundred clinical samples from infected Arabian horses, presenting respiratory disorders, diarrhea, abortion, wound, and ocular infection, were examined using direct sample multiplex PCR and phenotypic methods. Antimicrobial susceptibility testing of the recovered isolates was performed using pane...
Cheek tooth repulsion aided by computer-assisted surgery in 16 equids.
Frontiers in veterinary science    October 8, 2025   Volume 12 1571539 doi: 10.3389/fvets.2025.1571539
Klopfenstein Bregger MD, de Preux M, Brünisholz HP, Van der Vekens E, Schweizer D, Koch C.This retrospective case series reports on the use of computer-assisted surgery (CAS) to perform cheek tooth repulsion in 16 equids. Thirteen of the 16 subjects in this case series had a mandibular cheek tooth repulsed, and 3 had a maxillary cheek tooth removed. Surgery was performed on all subjects under general anesthesia, and all but one were placed in lateral recumbency. All cheek teeth were successfully removed by navigated repulsion, except in one case where additional intraoral sectioning was performed. In one horse, a surgical approach through the contralateral nasal conchae was made to...
Cronodent I, 3D interactive manual for self-learning of the dental chronology of equines.
Frontiers in veterinary science    October 2, 2025   Volume 12 1597710 doi: 10.3389/fvets.2025.1597710
Rodero E, González-Martínez A, Diz A, Rodero J.One of a veterinarian's routine tasks is animal identification, with age being a crucial factor in the identification and evaluation of individuals. Knowledge of the morphological changes in animal dentition used to determine their age is essential in veterinary education. Today's students increasingly prefer innovative learning tools that incorporate 3D anatomical models over traditional 2D resources. As part of a teaching innovation project at the University of Córdoba, Spain, new educational materials were developed to aid students in identifying the age of animals using 3D images of equin...
The effect of heel elevation on the stiffness gradient index of the digital flexor tendons in the equine forelimb of clinically normal horses.
Frontiers in veterinary science    October 1, 2025   Volume 12 1610788 doi: 10.3389/fvets.2025.1610788
Shaw KA, Brounts SH.To evaluate the effect of heel elevation on measurement of stiffness gradients by means of acoustoelastography in the digital flexor tendons of clinically normal horses. Unassigned: 15 clinically normal horses. Unassigned: For each horse, stiffness gradient index (SGI) for superficial digital flexor tendons (SDFT) and deep digital flexor tendons (DDFT) were evaluated in both forelimbs at 0, 4 and 8 degrees of heel elevation. Acoustoelastography (AEG) was used for data acquisition at three sites, approximately 6, 12, and 18 cm distal to the accessory carpal bone in the metacarpal region. Lif...