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Frontiers in veterinary science.
Publisher:
Frontiers Media S.A.,
Country: Switzerland
Language: English
Start Year:2014 -
ISSN:
2297-1769 (Electronic)
2297-1769 (Linking)
2297-1769 (Linking)
Impact Factor
3.2
2022
| NLM ID: | 101666658 |
| (OCoLC): | 908319805 |
| LCCN: | 2015243350 |
| Classification: | W1 |
Metabolomic analysis of synovial fluid from healthy and pathological equine joints and tendon sheaths using high-resolution 1H Nuclear Magnetic Resonance. Joint and tendon sheath diseases are a major cause of lameness and reduced performance in horses. Synovial fluid composition changes in response to pathological processes and metabolomic profiling offers a promising approach to detect these alterations. While equine joint metabolomics has been explored, little is known about the metabolomic profile of tendon sheaths. This study aimed to characterize and compare the synovial fluid metabolomic profiles of healthy and pathological joints and tendon sheaths in horses using high-resolution H Nuclear Magnetic Resonance spectroscopy, and to identify ...
Cyclooxygenase-2 and von Willebrand factor-an immunohistochemical study of the equine foot with and without laminitis, post-mortem perfused with paraffin oil. Equine laminitis is a complex and potentially fatal disease characterized by severe vascular and inflammatory alterations within the equine foot. This study aimed to develop immunohistochemistry (IHC) protocols for the detection of cyclooxygenase-2 (COX-2) and von Willebrand factor (vWF) in equine feet with and without laminitis, post-mortem perfused with paraffin oil. Unassigned: A total of 12 equine forelimbs from 8 horses were utilized in this study, divided into two study cohorts: one with laminitis and the other as a non-laminitis control. To develop the IHC protocols thoroughly, the tiss...
Correction: An anatomical study of the subarachnoid space surrounding the trigeminal ganglion in horses-in preparation for a controlled glycerol rhizotomy in equids. [This corrects the article DOI: 10.3389/fvets.2024.1424890.].
Geographic diversity of the Streptococcus equi subsp. equi accessory genome: implications for vaccines and global surveillance. Strangles, caused by the host-adapted subsp. (. ), imposes significant welfare and economic losses on the equine industry worldwide. Understanding its genomic features, virulence-associated genes (VAGs), antimicrobial resistance (AMR) and mobile genetic elements (MGEs) is essential for disease control and vaccine development. This study aimed to characterize the accessory genome composition, geographic distribution of VAGs and MGEs, and AMR profiles of . by a large-scale genomic analysis of global publicly available . sequences. All publicly available . sequences in the Sequence Read Arch...
Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target. Evidence suggests that the endocannabinoid system (ECS) is crucial for regulating inflammation, cell proliferation and pain. The ECS is composed of cannabinoid receptors such as type 1 (CBR1), type 2 (CBR2) and GPR55, endocannabinoids and enzymes. Proteins of ECS have previously been localized in the epidermal cells of the horse hooves. Given the physio-pathological role and cellular distribution of the ECS across species, the authors hypothesized that cannabinoid receptors are expressed within the inflammatory cells, fibroblasts and endothelial cells of the equine hoof laminae, going beyond t...
Equine-assisted learning and leadership transformation: an exploratory qualitative study of workplace behavior. This study explores how equine-assisted leadership development (EALD) interventions activate experiential processes that reshape leaders' self-concept, relational schemas, and behaviors. A conceptual model is proposed to explain how non-verbal interaction with horses catalyzes transformational learning. Unassigned: A qualitative exploratory design was employed to examine leaders' experiences over 12 months following reintegration into their workplaces. Eight leaders ( = 8) attended a 5-day EALD program, engaging in "join-up" exercises with horses. Data were analyzed through reflexive the...
‘Pretty devastating’: exploring horse owner and veterinarian lived experiences of the equine Hendra virus. With more than 60% of emerging infectious diseases being zoonotic, we apply a One Health lens that connects human, animal, and environmental dimensions of the response to a Hendra virus (HeV) event. One Health promotes collaboration among health professionals, veterinarians, environmental scientists, and policymakers to strengthen health infrastructure and improve responses to complex health threats. HeV is an uncommon high-consequence and potentially fatal zoonotic disease endemic to parts of Australia. Previous research has largely focused on the uptake of preparedness measures by veterinari...
Correction: Integrated molecular and serological survey of Rhodococcus equi in horses from three regions of Kazakhstan. [This corrects the article DOI: 10.3389/fvets.2025.1650186.].
Granulosa cell tumor in Arabian mares: prevalence, risk factors, clinical and histopathological findings and outcome of surgical removal. Granulosa cell tumors (GCTs) represent the most common ovarian neoplasms in mares, yet data on their epidemiology, risk factors, and clinical outcomes in Arabian horses are limited. Understanding their prevalence and diagnostic features is crucial for improving fertility management in this breed. Unassigned: Clinical records from 807 Arabian mares housed on 35 stud farms in central Saudi Arabia were retrospectively reviewed to determine the prevalence of GCT and potential risk factors, including age, parity, and anabolic steroid use. Twenty-four confirmed cases were further investigated using ...
Metabolism, pharmacokinetics, and bioavailability of cannabigerol in horses following intravenous and oral administration with micellar and oil formulations. Cannabigerol (CBG) is a non-psychoactive cannabinoid with growing interest in veterinary medicine; however, its pharmacokinetic profile in horses remains unknown. Understanding its absorption, distribution, metabolism, and elimination is essential to optimizing dosing strategies and evaluating its potential for clinical use in equine patients. Unassigned: A prospective crossover study was conducted in eight healthy adult horses to assess the metabolism and the pharmacokinetics after intravenous (IV) administration at 1 mg/kg and oral administrations at 10 mg/kg with two formulations (mice...
Impact of sequential administration of detomidine, butorphanol, and midazolam on sedation, ataxia, stimulus response, and bispectral index in horses. Standing sedation is a safe and cost-effective alternative to general anesthesia in horses, but challenges include achieving adequate drug effect to block the stimulus response without inducing ataxia or recumbency. A benefit of midazolam has been reported in equine dental procedures. Seeking synergy, a combination of lower doses of several pharmacologic agents, including midazolam, may improve the quality of sedation while minimizing adverse effects. Bispectral index (BIS) correlates with sedation scores in human ICU patients, but the correlation between sedation scores and BIS has not been e...
Fetometry in Arabian horses. This study aimed to monitor intrauterine fetal growth, establish predictive equations for gestational age estimation, and determine the optimal period for fetal sexing in Arabian horses using ultrasonography. Unassigned: Seven Arabian mares were monitored from insemination to parturition using transrectal ultrasonography. The following fetal and embryonic parameters were measured: embryonic vesicle (EV), crown-rump length (CRL), biparietal diameter (BIP), stomach diameter (STD), chest depth (CHD), abdominal diameter (ABD), kidney length (KDL), eyeball diameter (EBD), and eye lens length (ELL)....
Equine adipose-derived stem cells modulate in vitro neutrophil extracellular trap release by polymorphonuclear neutrophils. Neutrophil extracellular trap (NET) are thin and long web-like structures composed of DNA and antimicrobial proteins released by activated polymorphonuclear neutrophils (PMN) as part of the innate immune response. Adipose-derived stem cells (ADSCs) represent an accessible, abundant and minimal invasive source of mesenchymal stem cells (MSCs), with high regenerative potential, immunomodulatory and anti-inflammatory properties. Although recognized immunomodulatory properties of ADSCs, their interaction with PMN and their role on NET formation remains poorly characterized. The present study aimed...
Integrated molecular and serological survey of Rhodococcus equi in horses from three regions of Kazakhstan. is a facultative intracellular pathogen causing bronchopneumonia in foals; data from Central Asia are limited. We conducted a cross-sectional serological and molecular survey in horses from three regions of Kazakhstan (Kyzylorda, Almaty, Akmola). Unassigned: Sera from 312 animals (272 adults, 40 foals) on 20 farms were tested by indirect ELISA. Selected clinical samples underwent culture, PCR, and 16S rRNA sequencing. Unassigned: Overall seroprevalence was 8.3% (26/312; 95% CI 5.8-11.9). Positivity among foals was 25.0% (10/40; 95% CI 14.2-40.2) versus 5.9% (16/272; 95% CI 3.7-9.3) in adults,...
Correction: Prices for veterinary care of dogs, cats and horses in selected countries in Europe. [This corrects the article DOI: 10.3389/fvets.2024.1403483.].
Editorial: Advances in the application of technology for monitoring horse welfare and health. Flowchart illustrating interdisciplinary collaboration in animal research. A horse symbolizes the focus, with pathways connecting physiology, behavior, and environment to decision-making and regulatory indications. Data analysis, system understanding, and data interpretation lead to feedback and warning. Visual elements include sun, clouds, a light bulb, gears, and a graph.
Controlling drug-resistant bacteria in Arabian horses: bacteriophage cocktails for treating wound infections. Antimicrobial resistance is a major global health issue requiring a coordinated response. This study investigated for the first time the prevalence, antimicrobial resistance phenotypes of bacteria causing infections in Arabian horses, and the potential of bacteriophage therapy for wound treatment. One hundred clinical samples from infected Arabian horses, presenting respiratory disorders, diarrhea, abortion, wound, and ocular infection, were examined using direct sample multiplex PCR and phenotypic methods. Antimicrobial susceptibility testing of the recovered isolates was performed using pane...
Cheek tooth repulsion aided by computer-assisted surgery in 16 equids. This retrospective case series reports on the use of computer-assisted surgery (CAS) to perform cheek tooth repulsion in 16 equids. Thirteen of the 16 subjects in this case series had a mandibular cheek tooth repulsed, and 3 had a maxillary cheek tooth removed. Surgery was performed on all subjects under general anesthesia, and all but one were placed in lateral recumbency. All cheek teeth were successfully removed by navigated repulsion, except in one case where additional intraoral sectioning was performed. In one horse, a surgical approach through the contralateral nasal conchae was made to...
Cronodent I, 3D interactive manual for self-learning of the dental chronology of equines. One of a veterinarian's routine tasks is animal identification, with age being a crucial factor in the identification and evaluation of individuals. Knowledge of the morphological changes in animal dentition used to determine their age is essential in veterinary education. Today's students increasingly prefer innovative learning tools that incorporate 3D anatomical models over traditional 2D resources. As part of a teaching innovation project at the University of Córdoba, Spain, new educational materials were developed to aid students in identifying the age of animals using 3D images of equin...
The effect of heel elevation on the stiffness gradient index of the digital flexor tendons in the equine forelimb of clinically normal horses. To evaluate the effect of heel elevation on measurement of stiffness gradients by means of acoustoelastography in the digital flexor tendons of clinically normal horses. Unassigned: 15 clinically normal horses. Unassigned: For each horse, stiffness gradient index (SGI) for superficial digital flexor tendons (SDFT) and deep digital flexor tendons (DDFT) were evaluated in both forelimbs at 0, 4 and 8 degrees of heel elevation. Acoustoelastography (AEG) was used for data acquisition at three sites, approximately 6, 12, and 18 cm distal to the accessory carpal bone in the metacarpal region. Lif...
Computed tomographic signs of hyoid apparatus disease in 165 horses. Horses with hyoid bone disease may present with clinical symptoms such as exercise intolerance, resistance to ridden work, anorexia, or headshaking. This study aims to describe the computed tomographic (CT) signs and prevalence of hyoid disease and to evaluate their association with other CT changes of the head. Unassigned: In this study, four investigators conducted a retrospective analysis of their findings after reviewing the medical records of 200 horses that had undergone CT scans between 2009 and 2019. A total of 32 parameters were analyzed, and associations were evaluated between those ...
Correction: Risk assessment in equine anesthesia: a first evaluation of the usability, utility and predictivity of the two-part CHARIOT. [This corrects the article DOI: 10.3389/fvets.2024.1384525.].
Equine maxillofacial intraosseous cystic lesions: a retrospective study of 17 cases. Cystic and pseudocystic masses of the equine maxilla and mandible are rare lesions that result in clinically significant morbidity and/or mortality for the patient. Previous literature consists of case reports or case series. Few studies have addressed the variety of cystic lesions and comparative features. The aim of this study was to retrospectively describe the clinical signs, imaging findings, histopathologic diagnoses, treatments, and clinical outcomes for cystic masses in the equine maxilla and mandible. Unassigned: Cases were recruited from six sources including a pathology laboratory, ...
Progress in serology and molecular biology of equine parasite diagnosis: sustainable control strategies. Internal parasitic infections are a persistent challenge for horse owners, in the absence of effective vaccines and the growing challenge of drug resistance, leading many researchers to view current control strategies as unsustainable. Despite slow progress over the past two decades, effective parasitic diagnosis remains crucial for controlling infections and preventing the growing issue of drug resistance. This review examines the research progress in serological and molecular biological diagnostic methods for major equine parasites. Currently, most diagnostic techniques are based on genes su...
Optimizing equine standing sedation: continuous infusion of detomidine and butorphanol enhances stability but prolongs ataxia. This study aimed to compare the sedation quality and cardiorespiratory and behavioral effects of detomidine administered intravenously, either in intermittent boluses or as a continuous rate infusion, with butorphanol in horses pre-medicated with acepromazine for odontoplasty procedures. Unassigned: A prospective clinical study was conducted with fifteen adult horses randomly assigned to two groups: Bolus group (BG, = 7) and Infusion group (IG, = 8). Both groups received acepromazine premedication, followed by detomidine administration (bolus or infusion). Butorphanol was administered either...
Investigations on metabolic diseases of horses in Egypt. Obesity is a significant risk factor that predisposes horses to laminitis, equine metabolic syndrome, arthritis, heart disease, and respiratory issues. Unassigned: Mares showing overweight or laminitis ( = 30), different BCS ( = 90) weighing 350-550 Kg were subjected to clinical and rump fat assessments. Blood samples were collected to measure circulating estradiol, progesterone, cortisol, insulin, insulin-like growth factor-1 (IGF-1), and leptin. Additionally, glucose, cholesterol, triglycerides, total proteins, albumin, nitric oxide (NO), lactate dehydrogenase (LDH), glutathione redu...
Correction: Association between radiographic equine distal phalanx characteristics and absence, presence and type of horseshoes. [This corrects the article DOI: 10.3389/fvets.2025.1598038.].
Road transportation is associated with decreased intestinal motility in horses. Transportation of horses has been associated with colic and changes to the gastrointestinal microbiome. Percutaneous abdominal ultrasonography using wireless, point-of-care transducers can be used to assess gastrointestinal motility in field settings. Unassigned: Characterization of intestinal motility and salivary cortisol responses of horses completing commercial transportation of 10-12h. Unassigned: Prospective observational study of 30 horses with diverse signalment and transport histories. Clinical parameters, sonographic assessment of intestinal motility and saliva samples, were collecte...
Alactic base excess is not a sensitive or specific diagnostic tool for outcome in horses with colic. Colic is a significant source of morbidity and mortality in horses, and no single biomarker can distinguish surgical from medical colic or predict mortality. Alactic base excess (ABE) has shown an association with mortality and renal insufficiency in humans but has not been evaluated in veterinary species. The purpose of this study was to determine the value of ABE as a diagnostic tool for horses treated for gastrointestinal disease. Unassigned: This retrospective case series evaluated horses admitted for acute gastrointestinal disease over a 5-year period (2019-2024). Signalment, physical exa...
Horse vision through two lenses: Tinbergen’s Four Questions and the Five Domains. To improve human-horse interactions and reduce the risk of injury, it is essential to adopt an equi-centric perspective that prioritizes how horses perceive their environment. This review focuses on the equine visual system, both because it is the most studied of the horse's senses and because misunderstandings about how horses see can lead to unsafe or unsustainable handling. By applying two complementary frameworks, namely Tinbergen's Four Questions and the Five Domains model, we examine equine vision from both a biological and a welfare-oriented perspective. We explore the anatomical and fu...
