Archiv der Pharmazie.
Publisher:
Verlag Chemie GmbH.. Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA (2005)
Frequency: Monthly
Country: Germany
Language: ger
Author(s):
Deutsche Pharmazeutische Gesellschaft., Arbeitsgemeinschaft der Berufsvertretungen Deutscher Apotheker.
Start Year:1972 -
ISSN:
0365-6233 (Print)
1521-4184 (Electronic)
0365-6233 (Linking)
1521-4184 (Electronic)
0365-6233 (Linking)
Impact Factor
5.1
2022
| NLM ID: | 0330167 |
| (DNLM): | A60180000(s) |
| (OCoLC): | 01481904 |
| Coden: | ARPMAS |
| LCCN: | sn 78006714 |
| Classification: | W1 AR163C |
Anti-Alzheimer’s multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity. Serotonin 5-HT receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiology of Alzheimer's disease. Inhibition of BuChE provides symptomatic treatment of the disease and the same effect was demonstrated for 5-HT antagonists in clinical trials. Oxidative stress is regarded as a major and primary factor contributing to the development of Alzheimer's disease; therefore, antioxidant agents may provide a disease-modifying effect. Combining BuChE inhibition, 5-HT antagonism, and antioxidant properties may result in multitarget-directed ligands providing cognitio...