European journal of cancer : official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR).
Publisher:
Pergamon Press,. Oxford : Elsevier Science Ltd
Frequency: Eighteen no. a year, 2000-
Country: England
Language: English
Author(s):
European Organization for Research on Treatment of Cancer., European Association for Cancer Research.
Start Year:1990 -
ISSN:
0959-8049 (Print)
1879-0852 (Electronic)
0959-8049 (Linking)
1879-0852 (Electronic)
0959-8049 (Linking)
Impact Factor
8.4
2022
| NLM ID: | 9005373 |
| (OCoLC): | 21363349 |
| (DNLM): | SR0067988(s) |
| Coden: | EJCAEL |
| LCCN: | sn 90031189 |
| Classification: | W1 EU72BA |
Serum can inhibit reversal of multidrug resistance by chemosensitisers. The purpose of this study was to evaluate to what extent the ability of various chemosensitisers (CS) to reverse P-glycoprotein-associated multidrug resistance (MDR) is reduced when tested in physiological serum protein concentrations. Utilising drug sensitivity and accumulation assays, the CS were tested in medium containing 10% fetal bovine serum and in 100% horse or human serum. Two RPMI 8226 human myeloma sublines were used which express different levels of P-glycoprotein. The CS were tested at various concentrations, including clinically achievable blood levels. When using the CS at high ...