Human immunology.
Publisher:
Elsevier/North-Holland.
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Association for Clinical Histocompatibility Testing., American Society for Histocompatibility and Immunogenetics.
Start Year:1980 -
ISSN:
0198-8859 (Print)
1879-1166 (Electronic)
0198-8859 (Linking)
1879-1166 (Electronic)
0198-8859 (Linking)
Impact Factor
2.7
2022
| NLM ID: | 8010936 |
| (DNLM): | H22270000(s) |
| (OCoLC): | 06272568 |
| Coden: | HUIMDQ |
| LCCN: | 80648846 |
| Classification: | W1 HU448H |
Antithymocyte globulin is associated with complement deposition in cardiac transplant biopsies. Polyclonal antithymocyte globulin preparations contain antibodies with reactivity to endothelial cells. Therefore, we investigated whether treatment with this reagent caused complement deposition in human cardiac transplants. Frozen tissue was available from endomyocardial biopsies of 75 patients, who were transplanted between April 1995 and April 2000. Nine of these patients were converted from cyclosporin A (CsA) to horse antithymocyte globulin (ATGAM) in the first month after transplantation. All of the biopsies were stained by immunofluorescence for C4d as evidence of activation of the cla...