Molecular psychiatry.
Publisher:
Stockton Press,. Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals (2000)
Frequency: 8 no. a year, 2002-
Country: England
Language: English
Start Year:1996 -
ISSN:
1359-4184 (Print)
1476-5578 (Electronic)
1359-4184 (Linking)
1476-5578 (Electronic)
1359-4184 (Linking)
Impact Factor
11
2022
| NLM ID: | 9607835 |
| (DNLM): | SR0085765(s) |
| (OCoLC): | 35688553 |
| Coden: | MOPSFQ |
| Classification: | W1 MO1975 |
Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder. In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990, more than 80 studies have reported an association between BDV and a wide range of human illnesses that i...
Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies–the key marker triplet determining infection and prevailing in severe mood disorders. Borna disease virus (BDV), a unique genetically highly conserved RNA virus (Bornaviridae; Mononegavirales), preferentially targets neurons of limbic structures causing behavioral abnormalities in animals. Markers and virus in patients with affective disorders and schizophrenia have raised worldwide interest. A persistent infection was suggestive from follow-up studies, but inconstant detectability weakened a possible linkage.This study for the first time discloses that detection gaps are caused by BDV-specific circulating immune complexes (CIC), and their interplay with free antibodies and pla...