Neurobiology of aging.
Publisher:
Ankho International.. New York : Elsevier
Frequency: Monthly, 2006-
Country: United States
Language: English
Start Year:1980 -
ISSN:
0197-4580 (Print)
1558-1497 (Electronic)
0197-4580 (Linking)
1558-1497 (Electronic)
0197-4580 (Linking)
Impact Factor
4.2
2022
| NLM ID: | 8100437 |
| (DNLM): | N12490000(s) |
| (OCoLC): | 06035686 |
| Coden: | NEAGDO |
| LCCN: | 80647928 |
| Classification: | W1 NE323R |
Ferritin: the role of aluminum in ferritin function. We previously showed that human brain ferritin (HBF) binds aluminum (Al) in vivo and in vitro and HBF isolated from Alzheimer's brain had more Al bound compared to aged matched controls (7). To further understand the role ferritin may play in Al neurotoxicity, we have studied in vitro the effect of Al on the function of human ferritin isolated from Alzheimer's (AD) and normal brain tissue, and compared the results with other mammalian ferritins. Al causes a concentration-dependent decrease in the initial rate of iron loading into apo-horse spleen and human brain ferritin and the rates were sim...