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Home / Equine Research Bank / Bull Exp Biol Med / Antimicrobial Activity of Milk Whey in Different Mammals.
Bulletin of experimental biology and medicine2023; 175(3); 358-361; doi: 10.1007/s10517-023-05867-2

Antimicrobial Activity of Milk Whey in Different Mammals.

Abstract: Antimicrobial activity of milk whey in different mammals against Candida albicans yeast cells was studied by a spectrophotometric method. The activity increased in the order goat→horse→camel→cow→human→mouse. The level of whey activity in mice was higher by 3 and 10 times than in humans and goats, respectively. Similar changes were noted for activity of the whey fraction <100 kDa containing a complex of antimicrobial polypeptides, and there was a direct correlation between these two parameters (r=0.881; p<0.05). The total activity of whey had a high degree of correlation with the content of serum albumin (r=0.992); in mice, the level of serum albumin in the milk whey was close to that in blood serum. Interspecific differences between the activity of whey in mammals may be associated with qualitative and quantitative variability of the antimicrobial polypeptide composition, as well as their synergistic or antagonistic interaction with each other.
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
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Publication Date: 2023-08-10 PubMed ID: 37563534PubMed Central: 1665199DOI: 10.1007/s10517-023-05867-2Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates how effective milk whey from various mammals is at fighting off Candida albicans yeast cells. It finds that mouse milk whey is the most effective, followed by human, cow, camel, horse, and goat milk whey.

Research Method

  • The research studied the antimicrobial activity of milk whey in different mammals against Candida albicans yeast cells using a spectrophotometric method. Spectrophotometry is a technique that measures the amount of light absorbed by a sample. In this context, it allowed researchers to measure the level of yeast cell growth inhibited by the different types of milk whey.
  • The mammals used in this study, ranked from highest to lowest in antimicrobial activity, were mice, humans, cows, camels, horses, and goats.

Research Findings

  • The researchers found that mouse milk whey had the highest antimicrobial activity against Candida albicans, with this activity being 3 times higher than that of humans and 10 times higher than that of goats.
  • They also found activity in the whey fraction with less than 100 kilodaltons (a measure of molecular weight), implying that a set of antimicrobial peptides within that size range contributes to the milk’s germ-fighting ability.
  • Moreover, there was a very high correlation (r=0.992) between the total antimicrobial activity of the whey and the content of serum albumin, a protein found in blood and milk. In mouse milk whey, it was noted that the level of serum albumin nearly equaled that in blood serum.

Conclusions

  • The researchers theorize that interspecific differences in the levels of whey activity between different mammals could be due to the varying composition and concentration of antimicrobial polypeptides in each mammal’s milk whey.
  • They also suggest that the nature of the interaction between these peptides (whether they work synergistically to enhance each other’s effects, or antagonistically to reduce each other’s effects), could contribute to the different levels of antimicrobial activity seen in different mammal’s milk whey.

Cite This Article

APA
Kolyganova TI, Arzumanyan VG, Matvienko MA, Rodionova AA, Korshunova DS, Shatunova PO, Yastrebova NE. (2023). Antimicrobial Activity of Milk Whey in Different Mammals. Bull Exp Biol Med, 175(3), 358-361. https://doi.org/10.1007/s10517-023-05867-2

Publication

Bulletin of experimental biology and medicine
ISSN: 1573-8221
NlmUniqueID: 0372557
Country: United States
Language: English
Volume: 175
Issue: 3
Pages: 358-361

Researcher Affiliations

Kolyganova, T I
  • Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. tatianakolyganova@mail.ru.
  • I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. tatianakolyganova@mail.ru.
Arzumanyan, V G
  • I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Matvienko, M A
  • All-Russian Research Institute of Horse Breeding, Divovo, Rybnovsky district, Ryazan region, Russia.
Rodionova, A A
  • All-Russian Research Institute of Horse Breeding, Divovo, Rybnovsky district, Ryazan region, Russia.
Korshunova, D S
  • Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Shatunova, P O
  • Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Yastrebova, N E
  • I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.

MeSH Terms

  • Female
  • Cattle
  • Horses
  • Humans
  • Animals
  • Mice
  • Milk / chemistry
  • Whey / chemistry
  • Whey Proteins / pharmacology
  • Whey Proteins / analysis
  • Whey Proteins / chemistry
  • Mammals
  • Goats
  • Peptides / analysis

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