Association of the type of metabolic acidosis and non-survival of horses with colitis.
Abstract: Metabolic acidosis (MA) is the most common acid-base disorder reported in horses with colitis but its association with survival is yet to be determined. Investigate the types of MA in horses with colitis to determine effects of various anions on fatality rates. We studied 158 horses with colitis. Horses were classified into 4 groups depending on the anion contributing to MA: i) no MA, ii) lactic acidosis (LA), iii) unmeasured strong ion (USI) acidosis, and iv) hyperchloremic acidosis (HA). Sixty percent (95/158) of horses had no MA, 22% (34/158) had LA, 12% (19/158) had HA, and 6% (10/158) had USI acidosis. The fatality rate of horses without MA was 20% (20/95), whereas the rates for those with LA, USI, and HA were 53% (18/34), 30% (3/10), and 16% (3/19), respectively. Horses with LA were more likely to die or be euthanized than horses without MA (OR: 4.2, 95% CI: 1.83 to 9.72, P < 0.001) and HA (OR: 5.9, 95% CI: 1.47 to 24.4, P < 0.01). Lactic acidosis was the most common type of MA in horses with colitis, and it was associated with non-survival. Association du type d’acidose métabolique et de non-survie des chevaux atteints de colite. L’acidose métabolique (AM) est le trouble acido-basique le plus fréquemment signalé chez les chevaux atteints de colite, mais son association avec la survie reste à déterminer. Étudier les types d’AM chez les chevaux atteints de colite pour déterminer les effets de divers anions sur les taux de mortalité. Nous avons étudié 158 chevaux atteints de colite. Les chevaux ont été classés en 4 groupes en fonction de l’anion contribuant à l’AM : i) pas d’AM, ii) acidose lactique (LA), iii) acidose à ions forts non mesurés (USI) et iv) acidose hyperchlorémique (HA). Soixante pour cent (95/158) des chevaux n’avaient pas d’AM, 22 % (34/158) avaient une LA, 12 % (19/158) avaient une HA et 6 % (10/158) avaient une acidose USI. Le taux de mortalité des chevaux sans AM était de 20 % (20/95), tandis que les taux de ceux avec LA, USI et HA étaient de 53 % (18/34), 30 % (3/10) et 16 % (3/19), respectivement. Les chevaux atteints de LA étaient plus susceptibles de mourir ou d’être euthanasiés que les chevaux sans AM (OR : 4,2, IC à 95 % : 1,83 à 9,72, P < 0,001) et HA (OR : 5,9, IC à 95 % : 1,47 à 24,4, P < 0,01). L’acidose lactique était le type d’AM le plus courant chez les chevaux atteints de colite et elle était associée à la non-survie.(Traduit par Dr Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Publication Date: 2023-11-02 PubMed ID: 37915775PubMed Central: PMC10581353
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- Journal Article
Summary
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The research is a study of the effect of different types of metabolic acidosis on the survivability of horses with colitis. The study found that lactic acidosis is the most common and fatal type of metabolic acidosis in horses with colitis.
Introduction and Objectives
- The research is focused on studying the effects of different types of metabolic acidosis (MA) on horses diagnosed with colitis.
- While MA is a common acid-base disorder in horses with colitis, the specific relationship between MA and survival rates has not yet been established.
- The primary aim of the research was to investigate the impact of the distinct types of MA on the experiences and outcomes of horses with colitis.
Methodology
- 158 horses with colitis were studied and they were classified into four groups based on the anion contributing to MA. These groups were: i) no MA, ii) lactic acidosis (LA), iii) unmeasured strong ion (USI) acidosis, and iv) hyperchloremic acidosis (HA).
- The breakdown of the horses in each category was as follows: 60% (95/158) of the horses had no MA, 22% (34/158) had LA, 12% (19/158) had HA, and 6% (10/158) had USI acidosis.
Results
- The mortality rate of horses who had no MA was found to be 20% (20/95), while the rates for those with LA, USI, and HA were 53% (18/34), 30% (3/10), and 16% (3/19), respectively.
- Horses with LA were observed to be more likely to either die or be euthanized than horses without MA (with an odds ratio of 4.2 and a 95% confidence interval between 1.83 to 9.72) and those with HA (with an odds ratio of 5.9 and a 95% confidence interval between 1.47 to 24.4).
Conclusion
- The most common type of MA found in horses with colitis was LA.
- Most importantly, the study concluded there is a significant association between LA in horses with colitis and non-survival.
Cite This Article
APA
Giraldo AF, Carballo R, Serrenho RC, Tran V, Valverde A, Renaud DL, Gomez DE.
(2023).
Association of the type of metabolic acidosis and non-survival of horses with colitis.
Can Vet J, 64(11), 1044-1050.
Publication
Researcher Affiliations
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
- Departments of Clinical Studies (Giraldo, Carballo, Tran, Valverde, Gomez) and Population Medicine (Serrenho, Renaud), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1.
MeSH Terms
- Animals
- Horses
- Acidosis, Lactic / veterinary
- Acidosis / veterinary
- Colitis / veterinary
- Horse Diseases
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