Analyze Diet
CoDAS2025; 37(3); e20240083; doi: 10.1590/2317-1782/e20240083pt

Benefits of horseback riding for neurotypical children and adolescents: a scoping review.

Abstract: To investigate evidence of horse riding in the development of language, cognition, social, emotional, and behavioral aspects in neurotypical children and adolescents. Methods: Search in the databases of LILACS, MEDLINE, Web of Science, EMBASE, Scopus, and grey literature, without date or language restrictions. Registration in the Open Science Framework (OSF), under number DOI 10.17605/OSF.IO/32ETZ. For search strategies: "Equine-Assisted Therapy", "Child or Adolescent Development", Cognition, Socialization, and "Child Behavior". Methods: Randomized clinical trials and non-randomized experimental before-and-after studies, case series, and prospective observational studies of neurotypically developing people up to 18 years old. Studies with people with disabilities and neurodevelopmental disorders were excluded. Interventions researched: horse riding and animal-assisted therapy. Methods: Two judges identified primary studies independently by reading the titles and abstracts, considering the inclusion criteria; a third judge was consulted to resolve divergences. The risk of bias was assessed using the ROBINS-I and ROBINS 2 tools. Results: Altogether, 131 studies were obtained, and duplicates (27) were removed. Subsequently, 104 studies were analyzed and 77 were excluded. Of the 27 studies evaluated in full text, 21 were excluded. Six studies were eligible for this review - four non-randomized clinical studies and two randomized clinical trials. Conclusions: The non-randomized studies showed significant improvements in cognitive functions and behavioral and emotional aspects. The randomized studies, on the other hand, found significant gains in social competence. Objective: investigar evidências da equitação no desenvolvimento de linguagem, cognição, aspectos sociais, emocionais e comportamentais em crianças e adolescentes neurotípicos. Unassigned: Consulta nas bases de dados da Lilacs, MEDLINE, Web of Science, EMBASE, Scopus e literatura cinzenta, sem restrições de data ou idioma. Registro na plataforma Open Science Framework (OSF), sob número: DOI 10.17605/OSF.IO/32ETZ. Para estratégias de busca: “Equine-Assisted Therapy”, “Child or Adolescent Development", Cognition, Socialization e "Child Behavior”. Unassigned: Ensaios clínicos randomizados e estudos experimentais não randomizados de antes e depois, série de casos e observacionais prospectivos de pessoas com desenvolvimento neurotípico com até 18 anos de idade. Excluídos os estudos com pessoas com deficiência e transtornos do neurodesenvolvimento. Unassigned: Equitação e terapia assistida por animais. Análise dos dados: A identificação de estudos primários foi realizada por dois juízes de forma independente, por meio de leitura dos títulos e resumos baseada nos critérios de inclusão e um terceiro juiz era consultado para caso de desempate. O risco de viés foi avaliado pelas ferramentas ROBINS-I e a ROBINS-2. Results: Foram obtidos 131 estudos, sendo removidos os duplicados (27). Em seguida, 104 estudos foram analisados e 77 excluídos. Dos 27 estudos avaliados integralmente, 21 foram excluídos. Seis estudos foram elegíveis para esta revisão, sendo quatro estudos clínicos não randomizados e dois ensaios clínicos randomizados. Unassigned: Os estudos não randomizados apontaram melhoras significativas quanto às funções cognitivas, aspectos comportamentais e emocionais. Já os estudos randomizados, encontraram ganhos significativos quanto à competência social. investigar evidências da equitação no desenvolvimento de linguagem, cognição, aspectos sociais, emocionais e comportamentais em crianças e adolescentes neurotípicos. Consulta nas bases de dados da Lilacs, MEDLINE, , EMBASE, e literatura cinzenta, sem restrições de data ou idioma. Registro na plataforma Open Science Framework (OSF), sob número: DOI 10.17605/OSF.IO/32ETZ. Para estratégias de busca: “”, “", e "”. Ensaios clínicos randomizados e estudos experimentais não randomizados de antes e depois, série de casos e observacionais prospectivos de pessoas com desenvolvimento neurotípico com até 18 anos de idade. Excluídos os estudos com pessoas com deficiência e transtornos do neurodesenvolvimento. Equitação e terapia assistida por animais. Análise dos dados: A identificação de estudos primários foi realizada por dois juízes de forma independente, por meio de leitura dos títulos e resumos baseada nos critérios de inclusão e um terceiro juiz era consultado para caso de desempate. O risco de viés foi avaliado pelas ferramentas ROBINS-I e a ROBINS-2. Foram obtidos 131 estudos, sendo removidos os duplicados (27). Em seguida, 104 estudos foram analisados e 77 excluídos. Dos 27 estudos avaliados integralmente, 21 foram excluídos. Seis estudos foram elegíveis para esta revisão, sendo quatro estudos clínicos não randomizados e dois ensaios clínicos randomizados. Os estudos não randomizados apontaram melhoras significativas quanto às funções cognitivas, aspectos comportamentais e emocionais. Já os estudos randomizados, encontraram ganhos significativos quanto à competência social.
Publication Date: 2025-03-31 PubMed ID: 40172376PubMed Central: PMC11963882DOI: 10.1590/2317-1782/e20240083ptGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Scoping Review
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Overview

  • This study reviews existing research on the benefits of horseback riding for neurotypical children and adolescents, specifically its impact on language, cognition, social skills, emotional wellbeing, and behavior.

Research Objective

  • To investigate evidence on how horseback riding affects development in key areas for neurotypical children and adolescents, including language, cognition, social interaction, emotional health, and behavior.

Methodology

  • Data Sources: Comprehensive search across multiple databases such as LILACS, MEDLINE, Web of Science, EMBASE, Scopus, and grey literature, with no restrictions on date or language.
  • Registration: The research protocol was registered on the Open Science Framework (OSF) under DOI 10.17605/OSF.IO/32ETZ.
  • Search Terms: Included “Equine-Assisted Therapy,” “Child or Adolescent Development,” Cognition, Socialization, and “Child Behavior.”
  • Study Inclusion Criteria:
    • Randomized clinical trials (RCTs), non-randomized before-and-after studies, case series, and prospective observational studies focusing on neurotypical individuals up to age 18.
    • Excluded studies involving participants with disabilities or neurodevelopmental disorders.
  • Intervention Types: Horseback riding and animal-assisted therapy involving horses.
  • Study Selection Process:
    • Two independent reviewers screened titles and abstracts based on inclusion criteria.
    • Disagreements were resolved by consulting a third reviewer.
  • Risk of Bias: Assessed using the ROBINS-I (Risk Of Bias In Non-randomized Studies – of Interventions) and ROBINS-2 tools for randomized trials.

Study Selection and Results

  • A total of 131 studies were initially identified.
  • After removing 27 duplicates, 104 studies were screened.
  • 77 studies were excluded based on title and abstract review.
  • 27 full-text articles were reviewed in detail, with 21 excluded for not meeting criteria.
  • Six studies met eligibility:
    • Four were non-randomized clinical studies.
    • Two were randomized clinical trials.

Findings

  • From Non-Randomized Studies:
    • Significant improvements observed in cognitive functions among neurotypical children and adolescents.
    • Notable positive changes in behavioral and emotional aspects were reported.
  • From Randomized Clinical Trials:
    • Demonstrated significant gains in social competence, indicating enhanced social interaction skills.

Conclusions

  • Horseback riding and equine-assisted interventions may offer beneficial effects on the cognitive, behavioral, emotional, and social development of neurotypical children and adolescents.
  • Non-randomized evidence emphasizes cognitive and emotional-behavioral improvements, while randomized evidence particularly supports social competence gains.
  • The limited number of rigorous trials highlights the need for further high-quality research to confirm these findings.

Implications for Future Research and Practice

  • Additional randomized controlled trials with larger sample sizes are needed to strengthen evidence on horseback riding benefits for neurotypical youth.
  • Practitioners and educators might consider integrating horseback riding programs as a supportive activity to promote various developmental domains.
  • Future studies should also explore long-term effects and optimal intervention designs for maximum developmental impact.

Cite This Article

APA
Silva FGD, Paula DD, Alves LM, Santos JN. (2025). Benefits of horseback riding for neurotypical children and adolescents: a scoping review. Codas, 37(3), e20240083. https://doi.org/10.1590/2317-1782/e20240083pt

Publication

ISSN: 2317-1782
NlmUniqueID: 101623246
Country: Brazil
Language: por
Volume: 37
Issue: 3
Pages: e20240083
PII: e20240083

Researcher Affiliations

Silva, Flaviana Gomes da
  • Departamento da Pós-graduação em Ciências Fonoaudiológicas, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil.
Paula, Danielle Diniz de
  • Departamento da Pós-graduação em Ciências Fonoaudiológicas, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil.
Alves, Luciana Mendonça
  • Departamento da Pós-graduação em Ciências Fonoaudiológicas, Faculdade de Medicina, Universidade Federal de Minas Gerais - UFMG - Belo Horizonte (MG), Brasil.
Santos, Juliana Nunes
  • Instituto de Ciência e Tecnologia - ICTIN, Universidade Federal de Lavras - UFLA - Lavras (MG), Brasil.

MeSH Terms

  • Humans
  • Child
  • Adolescent
  • Equine-Assisted Therapy / methods
  • Horses
  • Animals
  • Cognition

Conflict of Interest Statement

nothing to declare.

References

This article includes 59 references
  1. Roessler M, Rink B. In: Atlas do esporte no Brasil. Dacosta L, editor. Rio de Janeiro: Conselho Federal de Educação Física; 2006. Esportes Hípicos.
  2. CBH: Confederação Brasileira de Hipismo . O Hipismo no Brasil e a CBH. Rio de Janeiro: CBH; 2012. [citado em 2024 Feb 11]. Disponível em: https://www.cbh.org.br/index.php/cbh/historico#n.
  3. Associação Nacional de Equoterapia . Parecer Conselho Federal de Medicina, 06/97. Brasília: Associação Nacional de Equoterapia; 1997.
  4. Wickert H. O cavalo como instrumento cinesioterapêutico. Equoterapia 1999;3(3):7–14.
  5. Prieto A, Ayupe KMA, Gomes LN, Saúde AC, Gutierres P. Effects of equine-assisted therapy on the functionality of individuals with disabilities: systematic review and meta-analysis. Physiother Theory Pract 2020;38(9):1091–1106.
    doi: 10.1080/09593985.2020.1836694pubmed: 33084452google scholar: lookup
  6. Hyun GJ, Jung TW, Park JH, Kang KD, Kim SM, Son YD. Changes in gait balance and brain connectivity in response to equine-assisted activity and training in children with attention deficit hyperactivity disorder. J Altern Complement Med 2016;22(4):286–293.
    doi: 10.1089/acm.2015.0299pubmed: 26982567google scholar: lookup
  7. Matsuura A, Maruta H, Iwatake T, Kumagai T, Nakanowatari T, Hodate K. The beneficial effects of horse trekking on autonomic nervous activity in experienced rider with no disability. Anim Sci J 2017;88(1):173–179.
    doi: 10.1111/asj.12584pubmed: 27072070google scholar: lookup
  8. Gilboa Y, Helmer A. Self-Management intervention for attention and executive functions using equine- assisted occupational therapy among children aged 6-14 diagnosed with attention deficit/hyperactivity disorder. J Altern Complement Med 2020;26(3):239–246.
    doi: 10.1089/acm.2019.0374pubmed: 31934771google scholar: lookup
  9. Niehues JR, Niehues MR. Equoterapia no Tratamento de Transtorno de Déficit de Atenção e Hiperatividade (TDAH): implicações Pedagógicas. Rev Neurocienc 2014;22(1):121–126.
  10. Maresca G, Portaro S, Naro A, Crisafulli R, Raffa A, Scarcella I. Hippotherapy in neurodevelopmental disorders: a narrative review focusing on cognitive and behavioral outcomes. Appl Neuropsychol Child 2020;11(3):553–560.
    doi: 10.1080/21622965.2020.1852084pubmed: 33949903google scholar: lookup
  11. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372(71):n71.
    doi: 10.1136/bmj.n71pmc: PMC8005924pubmed: 33782057google scholar: lookup
  12. Sterne JAC, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M. ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions. BMJ 2016;355:i4919.
    doi: 10.1136/bmj.i4919pmc: PMC5062054pubmed: 27733354google scholar: lookup
  13. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:l4898.
    doi: 10.1136/bmj.l4898pubmed: 31462531google scholar: lookup
  14. Silva FG, Alves LM, Celeste LC, De Paula DD, Passamani JD, Santos JN. Os efeitos da equitação nas funções cognitivas de crianças e adolescentes. Psicopedagogia 2023;40(123):324–333.
  15. Fonseca RP, de Salles JF, Parente MAMP. Development and content validity of the Brazilian Brief Neuropsychological Assessment Battery Neupsilin. Psychol Neurosci 2008;1(1):55–62.
    doi: 10.3922/j.psns.2008.1.009google scholar: lookup
  16. Salles JF, Fonseca RP, Cruz-Rodrigues C, Mello CB, Barbosa T, Miranda MC. Desenvolvimento do Instrumento de Avaliação Neuropsicológica Breve Infantil NEUPSILIN-INF. Psico-USF 2011;16(3):297–305.
  17. Norwood MF, Lakhani A, Maujean A, Downes M, Fullagar S, Barber B. The Horse as a Therapist: effects of an equine program without “therapy” on the attention and behavior of youth disengaged from traditional school. J Altern Complement Med 2021;27(8):1–22.
    doi: 10.1089/acm.2020.0500pubmed: 33945293google scholar: lookup
  18. Gioia GA, Isquith PK, Guy SC, Kenworthy L. Behavior rating inventory of executive function. Child Neuropsychol 2000;6(3):235–238.
    doi: 10.1076/chin.6.3.235.3152pubmed: 11419452google scholar: lookup
  19. Goodman R. Psychometric properties of the strengths and difficulties questionnaire. J Am Acad Child Adolesc Psychiatry 2001;40(11):1337–1345.
  20. Tsantefski M, Briggs L, Griffiths J, Tidyman A. An open trial of equine-assisted therapy for children exposed to problematic parental substance use. Health Soc Care Community 2017;25(3):1247–1256.
    doi: 10.1111/hsc.12427pubmed: 28147452google scholar: lookup
  21. Bachi K, Terkel J, Teichman M. Equine-facilitated psychotherapy for at-risk adolescents: the influence on self-image, self-control and trust. Clin Child Psychol Psychiatry 2012;17(2):298–312.
    doi: 10.1177/1359104511404177pubmed: 21757481google scholar: lookup
  22. Offer D, Ostrov E, Howard KI. The Offer self image questionnaire for adolescents, a manual. J Youth Adolesc 1977;6(3):265–280.
    doi: 10.1007/BF02138939pubmed: 24408456google scholar: lookup
  23. Rosenbaum M. A schedule for assessing self-controlled behavior: preliminary findings. Behav Ther 1980;11(1):109–121.
  24. Hochreich DJ. A children’s scale to measure interpersonal trust. Dev Psychol 1973;9(1):141.
    doi: 10.1037/h0035085google scholar: lookup
  25. Huebner ES. Initial development of the student’s life satisfaction scale. Sch Psychol Int 1991;12(3):231–240.
    doi: 10.1177/0143034391123010google scholar: lookup
  26. Pendry P, Carr AM, Smith AN, Roeter SM. Improving adolescent social competence and bahavior: a randomized trial of an 11-week equine facilited learning prevention program. J Prim Prev 2014;35(4):281–293.
    doi: 10.1007/s10935-014-0350-7pubmed: 24898318google scholar: lookup
  27. LeBuffe PA, Shapiro VB, Naglieri JA. The Devereux Student Strengths Assessment (DESSA): assessment, technical manual and user’s guide. Charlotte: Apperson,Inc.; 2009.
  28. Chandler C. Animal assisted therapy in counseling. New York: Routledge; 2005.
    doi: 10.4324/9780203956755google scholar: lookup
  29. Hauge H, Kvalem IL, Berget B, Enders-Slegers MJ, Braastad BO. Equine-assisted activities and the impact on perceived social support, self-esteem and self-efficacy among adolescents- an intervention study. Int J Adolesc Youth 2014;19(1):1–21.
  30. Hjemdal O, Aune T, Reinfjell T, Stiles TC, Friborg O. Resilience as a predictor of depressive symptoms: A correlational study with young adolescents. Clin Child Psychol Psychiatry 2007;12(1):91–104.
    doi: 10.1177/1359104507071062pubmed: 17375811google scholar: lookup
  31. Rudasill KM, Callahan CM. Psychometric characteristics of the Harter self-perception profiles for adolescents and children for use with gifted populations. Gift Child Q 2008;52(1):70–86.
    doi: 10.1177/0016986207311056google scholar: lookup
  32. Luszczynska A, Scholz U, Schwarzer R. The general self-efficacy scale: multicultural validation studies. J Psychol 2005;139(5):439–457.
    doi: 10.3200/JRLP.139.5.439-457pubmed: 16285214google scholar: lookup
  33. Traeen B, Wang CE. Perceived gender attribution, self-esteem, and general selfefficacy in female horseback riders. J Equine Vet Sci 2006;26(10):439–444.
  34. Klostermann F, Krugel LK, Ehlen F. Functional roles of the thalamus for language for language capacities. Front Syst Neurosci 2013;16:7–32.
    doi: 10.3389/fnsys.2013.00032pmc: PMC3712252pubmed: 23882191google scholar: lookup
  35. Mourão CA Jr, Melo LBR. Integração de três conceitos: função executiva, memória de trabalho e aprendizado. Psicol, Teor Pesqui 2011;27(3):309–314.
  36. Diamond A, Lee K. Interventions shown to aid executive function development in children 4 to 12 years old. Science 2011;333(6045):959–964.
    pmc: PMC3159917pubmed: 21852486
  37. Melby-Lervåg M, Lyster SAH, Hulme C. Phonological skills and their role in learning to read: a meta-analytic review. Psychol Bull 2012;138(2):322–352.
    doi: 10.1037/a0026744pubmed: 22250824google scholar: lookup
  38. Martins-Reis VO, Pedroso DAA, Almeida LM, Pereira ES, Alves LM, Celeste LC. A fluência e compreensão leitora como indicador de desempenho no 3o ano do Ensino Fundamental. CoDAS 2023;35(6):e20210251.
    pmc: PMC10547134pubmed: 37672411
  39. Seabra AG, Dias NM. Reconhecimento de palavras e compreensão de leitura : dissociação e habilidades linguístico-mnemônicas preditoras. Revista Neuropsicologia Latinoamericana 2012;4(1):43–56.
  40. Song S, Su M, Kang C, Liu H, Zhang Y, McBride-Chang C. Tracing children’s vocabulary development from preschool through the school-age years: an 8-year longitudinal study. Dev Sci 2015;18(1):119–131.
    doi: 10.1111/desc.12190pmc: PMC4276547pubmed: 24962559google scholar: lookup
  41. Dias NM, Bueno JOS, Pontes JM, Mecca TP. Linguagem oral e escrita na Educação Infantil: relação com variáveis ambientais. Psicol Esc Educ 2019;23:e178467.
  42. Zequinão MA, Cardoso AA, Silva JL, Medeiros P, Silva MAL, Pereira B. Academic performance and bullying in socially vulnerable students. J Hum Growth Dev 2017;27(1):19–27.
    doi: 10.7322/jhgd.127645google scholar: lookup
  43. Prestes DB, Weiss S, Araujo JCO. A equoterapia no desenvolvimento motor e autopercepção de escolares com dificuldade de aprendizagem. Ciências & Cognição 2010;15(3):192–203.
  44. Arrigo IV. Avaliação da conectividade efetiva cerebral da fluência verbal semântica de ressonância magnética. Ribeirão Preto: Universidade de São Paulo, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto; 2020. [dissertação].
  45. Medeiros M, Dias E. Equoterapia: bases e fundamentos. Rio de Janeiro: Revinter; 2002.
  46. Uchiyama H, Ohtani N, Ohta M. Three-dimensional analysis of horse and human gaits in therapeutic riding. Appl Anim Behav Sci 2011;135(4):271–276.
  47. Barbosa GO, van Munster MA. O efeito de um programa de equoterapia no desenvolvimento psicomotor de crianças com indicativos de transtorno de deficit de atenção e hiperatividade. Rev Bras Educ Espec 2014;20(1):69–84.
  48. Jang B, Song J, Kim J, Kim S, Lee J, Shin H-Y. Equine-assisted activities and therapy for treating children with attention-deficit/hyperactivity disorder. J Altern Complement Med 2015;21(9):546–553.
    doi: 10.1089/acm.2015.0067pubmed: 26167851google scholar: lookup
  49. Oh Y, Joung Y-S, Jang B, Yoo JH, Song J, Kim J. Efficacy of hippotherapy versus pharmacotherapy in attention-deficit/hyperactivity disorder: a randomized clinical trial. J Altern Complement Med 2018;24(5):463–471.
    doi: 10.1089/acm.2017.0358pubmed: 29641212google scholar: lookup
  50. Trotter KS, Chandler CK, Goodwin-Bond D, Casey J. A comparative study of the efficacy of group equine assisted counseling with at-risk children and adolescents. J Creativity Ment Health 2008;3(3):1–42.
  51. Elias LCS, Amaral MV. Habilidades Sociais, Comportamentos e Desempenho Acadêmico em escolares antes e após intervenção. Psico-USF 2016;21(1):49–61.
  52. Holmes CMP, Goodwin D, Redhead ES, Goymour KL. The benefits of equine-assisted: an exploratory study. Child Adolesc Social Work J 2012;29:111–122.
    doi: 10.1007/s10560-011-0251-zgoogle scholar: lookup
  53. Wilkie KD, Germain S, Theule J. Evaluating the efficacy of equine therapy among at-risk youth: a meta-analysis. Anthrozoos 2016;29(3):377–393.
  54. Alfonso SV, Alfonso LA, Llabre MM, Fernandez MI. Project Stride: an equine-assisted intervention to reduce symptoms of social anxiety in young women. Explore (NY) 2015;11(6):461–467.
    doi: 10.1016/j.explore.2015.08.003pubmed: 26386749google scholar: lookup
  55. Galvão TF, Pereira MG. Avaliação da qualidade da evidência de revisões sistemáticas. Epidemiol Serv Saude 2015;24(1):173–175.
  56. Pendry P, Smith NA, Roeter SM. Randomized trial examines effects of equine facilitated learning on adolescent’s basal cortisol levels. Hum Anim Interact Bull 2014;2(1):80–95.
  57. Miranda VSG, Marcolino MAZ, Rech RS, Barbosa LR, Fischer GB. Fonoaudiologia baseada em evidências: o papel das revisões sistemáticas. CoDAS 2019;31(2):e20180167.
    doi: 10.1590/2317-1782/20182018167pubmed: 30892421google scholar: lookup
  58. Silva JRA, Lima FG, Silva CS, Ribeiro ACS. Effects of equotherapy on balance, spasticity and body symmetry of children with cerebral palsy: systematic review. Arch Health Sci 2022;29(1):31–35.
  59. Lopes J, Camilo AO, Nascimento DK, Mattos GP, Stockler GA, Mazur TB. Effectiveness of hippotherapy in autism spectrum disorder approach: a systematic review of clinical trials. Braz J Health Rev 2021;4(6):27627–27641.
    doi: 10.34119/bjhrv4n6-320google scholar: lookup

Citations

This article has been cited 1 times.
  1. Curcio F, Ivziku D, Pirisinu S, Bertocchi L, Gioiello G, Camoglio FS, Rangel Restrepo A, Notarnicola I, Aviles Gonzalez CI. Parents' Perceptions of Pediatric Surgical Patients Regarding Animal-Assisted Therapy: A Qualitative Study.. Healthcare (Basel) 2025 Sep 3;13(17).
    doi: 10.3390/healthcare13172207pubmed: 40941560google scholar: lookup