Classification of leptospira from the eyes of horses suffering from recurrent uveitis.
Abstract: No abstract available
Publication Date: 2004-04-27 PubMed ID: 15107036DOI: 10.1111/j.1439-0450.2004.00740.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research presents a detailed study into the causative agent of equine recurrent uveitis (ERU) in horses, revealing a strong correlation with a type of bacteria called leptospira, predominantly the Grippotyphosa group, and suggests that while multiple serovars can infect the eye, only a select few can persist and cause disease.
Objective of the Study
- The primary objective of the research was to understand, in depth, the agent responsible for equine recurrent uveitis (ERU), a common condition in horses that is not completely comprehended. While studies have linked ERU to leptospira infection, this research endeavors to isolate and identify the specific strains that are capable of causing persistent infections, ultimately leading to ERU.
Methodology and Results
- The researchers utilized intraocular samples collected from 501 horses across various Western European countries including Germany, Switzerland, Austria, The Netherlands, Luxembourg, Great Britain, Italy and Poland.
- A thorough analysis found that leptospira was isolated from 32.2% of these samples, indicating its possible role in ERU pathogenesis.
- Most of these leptospira isolates belonged to the Grippotyphosa group (78.2%), while a minority belonged to the Australis group (14.2%), the Sejroe group (3.6%), the Pomona group (2.5%), and the Javanica group (1.5%).
Highlighting Serovars
- The study also identified two types within the Grippotyphosa serovar, namely type Moskva and type Duyster, the latter being strongly associated with ERU in Western Europe due to phenotypic and genotypic differences.
- The limited variety of serovars isolated from the eyes of horses with ERU compared to the breadth of existing types suggests that while numerous leptospira serovars could cause initial infection, only a handful are able to persist and evoke the prolonged disease state.
Conclusions and Hypotheses
- This research offers critical insights into the bacteriological pathogenesis of ERU, spotlighting the role of specific leptospira serovars.
- The results indicate a need for further investigations to understand the unique survival mechanisms of these serovars in the horse’s eye, which may aid in the development of more effective ERU treatment and prevention strategies.
Cite This Article
APA
Hartskeerl RA, Goris MG, Brem S, Meyer P, Kopp H, Gerhards H, Wollanke B.
(2004).
Classification of leptospira from the eyes of horses suffering from recurrent uveitis.
J Vet Med B Infect Dis Vet Public Health, 51(3), 110-115.
https://doi.org/10.1111/j.1439-0450.2004.00740.x Publication
Researcher Affiliations
- Department of Biomedical Research, Leptospirosis Reference Centre (WHO/FAO/OIE/RIVM), Royal Tropical Institute, Amsterdam, The Netherlands. r.hartskeerl@kit.nl
MeSH Terms
- Animals
- Female
- Germany
- Horse Diseases / microbiology
- Horses
- Leptospira / classification
- Leptospira / pathogenicity
- Leptospirosis / microbiology
- Leptospirosis / veterinary
- Male
- Recurrence
- Serotyping
- Uveitis / immunology
- Uveitis / microbiology
- Uveitis / veterinary
- Vitreous Body / microbiology
Citations
This article has been cited 17 times.- Żmudzki J, Ostrowska M, Arent Z, Frant M, Kochanowski M, Nowak A, Zębek S, Kalinowski D, Podgórska K. Seroprevalence of equine leptospirosis in Poland (2019-2023). Equine Vet J 2026 Mar;58(2):523-532.
- Zečević I, Picardeau M, Vince S, Hađina S, Perharić M, Štritof Z, Stevanović V, Benvin I, Turk N, Lohman Janković I, Habuš J. Association between Exposure to Leptospira spp. and Abortion in Mares in Croatia. Microorganisms 2024 May 21;12(6).
- Hamond C, Adam EN, Stone NE, LeCount K, Anderson T, Putz EJ, Camp P, Hicks J, Stuber T, van der Linden H, Bayles DO, Sahl JW, Schlater LK, Wagner DM, Nally JE. Identification of equine mares as reservoir hosts for pathogenic species of Leptospira. Front Vet Sci 2024;11:1346713.
- Strutzberg-Minder K, Ullerich A, Dohmann K, Boehmer J, Goris M. Comparison of Two Leptospira Type Strains of Serovar Grippotyphosa in Microscopic Agglutination Test (MAT) Diagnostics for the Detection of Infections with Leptospires in Horses, Dogs and Pigs. Vet Sci 2022 Aug 29;9(9).
- Wollanke B, Gerhards H, Ackermann K. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis. Microorganisms 2022 Feb 7;10(2).
- Geiger T, Gerhards H, Wollanke B. Detection of Anti-LipL32 Antibodies in Serum Samples from Horses with Chronic Intraocular Infection with Leptospira spp. Pathogens 2021 Oct 14;10(10).
- Tirosh-Levy S, Baum M, Schvartz G, Kalir B, Pe'er O, Shnaiderman-Torban A, Bernstein M, Blum SE, Steinman A. Seroprevalence of Leptospira spp. in Horses in Israel. Pathogens 2021 Apr 1;10(4).
- Fagre AC, Mayo CE, Pabilonia KL, Landolt GA. Seroprevalence of Leptospira spp. in Colorado equids and association with clinical disease. J Vet Diagn Invest 2020 Sep;32(5):718-721.
- Guedes IB, de Souza GO, de Oliveira LAR, Castro JFP, de Souza Filho AF, Maia ALP, Heinemann MB. Prevalence of Leptospira serogroups in buffaloes from the Brazilian Amazon. Vet Med Sci 2020 Aug;6(3):433-440.
- Malalana F, Blundell RJ, Pinchbeck GL, Mcgowan CM. The role of Leptospira spp. in horses affected with recurrent uveitis in the UK. Equine Vet J 2017 Nov;49(6):706-709.
- Kulbrock M, Lehner S, Metzger J, Ohnesorge B, Distl O. A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. PLoS One 2013;8(8):e71619.
- Balamurugan V, Gangadhar NL, Mohandoss N, Thirumalesh SR, Dhar M, Shome R, Krishnamoorthy P, Prabhudas K, Rahman H. Characterization of leptospira isolates from animals and humans: phylogenetic analysis identifies the prevalence of intermediate species in India. Springerplus 2013;2:362.
- Verma A, Matsunaga J, Artiushin S, Pinne M, Houwers DJ, Haake DA, Stevenson B, Timoney JF. Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis. Clin Vaccine Immunol 2012 Mar;19(3):452-6.
- Verma A, Kumar P, Babb K, Timoney JF, Stevenson B. Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins. PLoS Negl Trop Dis 2010 Aug 3;4(8):e778.
- Båverud V, Gunnarsson A, Engvall EO, Franzén P, Egenvall A. Leptospira seroprevalence and associations between seropositivity, clinical disease and host factors in horses. Acta Vet Scand 2009 Mar 30;51(1):15.
- Verma A, Rathinam SR, Priya CG, Muthukkaruppan VR, Stevenson B, Timoney JF. LruA and LruB antibodies in sera of humans with leptospiral uveitis. Clin Vaccine Immunol 2008 Jun;15(6):1019-23.
- Verma A, Artiushin S, Matsunaga J, Haake DA, Timoney JF. LruA and LruB, novel lipoproteins of pathogenic Leptospira interrogans associated with equine recurrent uveitis. Infect Immun 2005 Nov;73(11):7259-66.
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