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Journal of personalized medicine2023; 13(12); doi: 10.3390/jpm13121647

Clinical and Biochemical Implications of Hyaluronic Acid in Musculoskeletal Rehabilitation: A Comprehensive Review.

Abstract: Hyaluronic acid (HA) naturally occurs as a biopolymer in the human body, primarily in connective tissues like joints and skin. Functioning as a vital element of synovial fluid, it lubricates joints, facilitating fluid movement and diminishing bone friction to protect articular well-being. Its distinctive attributes encompass notable viscosity and water retention capacities, ensuring flexibility and absorbing shock during motion. Furthermore, HA has gained significant attention for its potential benefits in various medical applications, including rehabilitation. Ongoing research explores its properties and functions, especially its biomedical applications in several clinical trials, with a focus on its role in improving rehabilitation outcomes. But the clinical and biochemical implications of HA in musculoskeletal rehabilitation have yet to be fully explored. This review thoroughly investigates the properties and functions of HA while highlighting its biomedical applications in different clinical trials, with a special emphasis on its role in rehabilitation. The presented findings provide evidence that HA, as a natural substance, enhances the outcomes of musculoskeletal rehabilitation through its exceptional mechanical and biochemical effects.
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Publication Date: 2023-11-26 PubMed ID: 38138874PubMed Central: PMC10744407DOI: 10.3390/jpm13121647Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the role of Hyaluronic acid (HA), a biopolymer naturally found in human body tissues, in musculoskeletal rehabilitation. The paper delves into its unique properties and functions within the body, how these are used in medical applications, especially in rehabilitation, and the need for further exploration of this substance’s clinical implications.

Role of Hyaluronic Acid (HA) in the Human Body

  • HA primarily exists in connective tissues such as joints and skin. It serves as a key component of synovial fluid, a substance that lubricates joints, ensuring smooth motion and reducing bone friction, thereby preserving joint health.
  • HA’s unique properties include high viscosity and water retention capacities which provide flexibility and absorb shocks during movement, further protecting joints from damage.

Applications of Hyaluronic Acid in Medical Science

  • Due to its advantageous properties, HA has gained substantial attention in the medical field. It has found potential uses in different areas, including the field of rehabilitation.
  • Research is ongoing to explore HA’s properties and functions, specifically its biomedical applications. Numerous clinical trials are focusing on the role of HA in improving rehabilitation outcomes.

Focus on Hyaluronic Acid in Musculoskeletal Rehabilitation

  • This research article takes a deep dive into how HA impacts musculoskeletal, or, movement related, rehab and recovery. While its implications have not yet been fully explored in this context, the review provides a comprehensive examination of HA’s properties and functions.
  • Some of the medical trials noted in the study specially emphasize the role of HA in the field of rehabilitation. These trials generally suggest that as a natural substance, HA can enhance musculoskeletal rehabilitation outcome by providing both mechanical and biochemical benefits.

Further Study of Hyaluronic Acid’s Role in Rehabilitation

  • The review stresses the need for more thorough investigation into the clinical and biochemical implications of HA in musculoskeletal rehabilitation.
  • As per the research conducted so far, promising evidence suggests that HA can positively impact the outcomes of musculoskeletal rehabilitation, which makes it worthy of further study.

Cite This Article

APA
Iaconisi GN, Gallo N, Caforio L, Ricci V, Fiermonte G, Della Tommasa S, Bernetti A, Dolce V, Farì G, Capobianco L. (2023). Clinical and Biochemical Implications of Hyaluronic Acid in Musculoskeletal Rehabilitation: A Comprehensive Review. J Pers Med, 13(12). https://doi.org/10.3390/jpm13121647

Publication

Journal of personalized medicine
ISSN: 2075-4426
NlmUniqueID: 101602269
Country: Switzerland
Language: English
Volume: 13
Issue: 12

Researcher Affiliations

Iaconisi, Giorgia Natalia
  • Department of Biological and Environmental Science and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy.
Gallo, Nunzia
  • Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy.
Caforio, Laura
  • Department of Basic Medical Sciences, Neurosciences and Sense Organs, Aldo Moro University, 70121 Bari, Italy.
Ricci, Vincenzo
  • Physical and Rehabilitation Medicine Unit, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Fiermonte, Giuseppe
  • Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.
Della Tommasa, Simone
  • Department for Horses, Faculty of Veterinary Medicine, Leipzig University, 04109 Leipzig, Germany.
Bernetti, Andrea
  • Department of Biological and Environmental Science and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy.
Dolce, Vincenza
  • Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Farì, Giacomo
  • Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy.
Capobianco, Loredana
  • Department of Biological and Environmental Science and Technologies (Di.S.Te.B.A.), University of Salento, 73100 Lecce, Italy.

Conflict of Interest Statement

The authors declare no conflict of interest.

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