Clinical and histopathological comparative study of two equine-derived bone graft: a human study.
Abstract: To compare the performance of collagenated bone graft substances with different collagen ratios after sinus floor augmentation. Methods: The cross-sectional study was conducted at Hacettepe University, Ankara, Turkey, from September 2011 to September 2013. Sinus floor augmentation was done with two different equinederived xenografts in patients before dental implant application. Of the two randomised groups, one was treated with 100% collagenated bone mix (Group A), and the other half with 90% collagenated bone mix + 10% collagen gel (Group B).Six months after sinus augmentation, prior to dental implant surgery, a specimen was taken from the implant socket with trephine drill for histopathological evaluation of new bone, connective tissue and residual graft material at each augmented site. SPSS 19 was used for data analysis. Results: Of the 19 patients, 12(63%) were females and 7(37%) were males. The overall mean age was 51.68±11,96 years (range: 24-69 years). A total of 30 sinus floor augmentations were done. New bone formation was significantly better in Group A(15 sinus floor augmentation) than in Group B (the other 15 sinus floor augmentation) (p<0.05), but there was no significant difference in connective tissue formation and residual graft materials between the groups (p>0.05). Conclusions: Collagenated bone mix was found to be a suitable graft material for sinus floor augmentation, but increased collagen ratio did not improve new bone formation over the 6-month healing process.
Publication Date: 2019-11-20 PubMed ID: 31740866DOI: 10.5455/JPMA.296194.Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research article investigates the effectiveness of two different types of bone grafts derived from horses (equine-derived). The authors looked at the amount of new bone growth, residual grafting material, and connective tissue growth following sinus floor augmentation. They found that a 100% collagenated bone mix performed better than a mix of 90% collagenated bone and 10% collagen gel in terms of new bone growth over a six-month period.
Methodology
- The study was conducted at Hacettepe University in Ankara, Turkey between 2011 and 2013.
- The researchers performed sinus floor augmentations, a procedure to increase bone volume in the upper jaw, on 19 patients who were preparing to receive dental implants.
- The patients were divided into two groups for their augmentations. One group received an equine-derived graft composed of 100% collagenated bone (Group A), while the other received a graft that was 90% collagenated bone and 10% collagen gel (Group B).
- Six months after the augmentation surgery, a sample was taken from the augmented site for histopathological evaluation. This sample was used to gauge the amount of new bone growth, connective tissue formation, and the amount of residual graft material.
Results
- Out of the 19 patients, 12 were female, and 7 were male, with the average age being around 52 years old.
- A total of 30 sinus floor augmentations were performed.
- The study found significant improvement in new bone formation in Group A compared to Group B. However, no significant difference was found between the two groups in terms of connective tissue formation and residual graft material presence.
Conclusion
- The findings suggest that collagenated bone mix serves as a suitable graft material for sinus floor augmentations.
- An increased ratio of collagen in the mix did not improve new bone formation over a six-month healing period.
Cite This Article
APA
Adiloglu S, Giray CB, Kulac I, Usubutun A, Aktas A.
(2019).
Clinical and histopathological comparative study of two equine-derived bone graft: a human study.
J Pak Med Assoc, 69(11), 1617-1622.
https://doi.org/10.5455/JPMA.296194. Publication
Researcher Affiliations
- Department of Oral and Maxillofacial Surgery, Hacettepe University, Ankara, Turkey.
- Private Practice, Ankara, Turkey.
- Department of Pathology, Hacettepe University, Ankara, Turkey.
- Department of Pathology, Hacettepe University, Ankara, Turkey.
- Department of Oral and Maxillofacial Surgery, Hacettepe University, Ankara, Turkey.
MeSH Terms
- Adult
- Aged
- Animals
- Bone Substitutes / chemistry
- Bone Substitutes / therapeutic use
- Bone and Bones / chemistry
- Bone and Bones / pathology
- Cross-Sectional Studies
- Female
- Horses
- Humans
- Male
- Middle Aged
- Osseointegration / physiology
- Sinus Floor Augmentation / methods
- Transplantation, Heterologous / methods
- Turkey
- Young Adult
Citations
This article has been cited 1 times.- Romasco T, Tumedei M, Inchingolo F, Pignatelli P, Montesani L, Iezzi G, Petrini M, Piattelli A, Di Pietro N. A Narrative Review on the Effectiveness of Bone Regeneration Procedures with OsteoBiol(®) Collagenated Porcine Grafts: The Translational Research Experience over 20 Years. J Funct Biomater 2022 Aug 18;13(3).
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