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Comparative histochemical studies on carbohydrate, lipid and RNA metabolism in the placenta and foetal membranes.
Abstract: Carbohydrate (particularly glycogen), lipid and RNA were among the substances earliest to be described in the placenta. The papers of Wislocki and his associates (1946a, b, c, 1948) have been supplemented by studies in several species (Hafez, 1964). Recently the distribution of glycogen has been re-examined using modern specific techniques (Christie, 1966a) and some correlation between the distribution of glyco-gen and certain specific alkaline phosphatases has been made (Christie, 1967a). Many enzymes relevant to the metabolism of glycogen, lipid and RNA can be demonstrated histochemically, and some deductions regarding possible metabolic pathways which these substances may follow in the tissues can be made from the enzymes present therein. The distribution of some of these enzymes has already been described (Christie, 1966b, 1967b). In this paper the distribution of dehydrogenase enzymes concerned with the metabolism of glycogen, lipid and RNA is described in each of the major placental types, and some deductions regarding possible function of the metabolic pathways thus demonstrated in the tissues are made. In addition the descriptions by previous authors of the distribution of lipid and RNA are extended to allow correlation between their occurrence and certain of the enzymes demonstrated (for details of glycogen distribution see Christie (1967a)).
Publication Date: 1968-06-01 PubMed ID: 5691968PubMed Central: PMC1231877 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article discusses the comparative studies on carbohydrate, specifically glycogen, lipid, and RNA metabolism in placenta and fetal membranes, using histochemical methods to identify the presence and distribution of related metabolic enzymes.
Article Explanation
This research seeks to understand how substances like carbohydrates, lipids, and RNA are metabolized in pregnancy-related tissues such as the placenta and fetal membranes, which play crucial roles in fetal development and health. It builds on previous research from Wislocki and Hafez and employs histochemical methods to provide a detailed picture of the metabolic processes.
- Starting with the discussion of carbohydrates, particularly glycogen, the study refers to previous findings from authors like Wislocki and Christie. The research also addresses the correlation between the distribution of glycogen and certain specific alkaline phosphatases studied by Christie.
- Next, the explanation of lipid metabolism follows. Again, elements of previous works that have contributed to the topic are mentioned, signaling a continuity in the research.
- The paper also analyzes RNA metabolism and the distribution of related enzymes. RNA is a molecule essential to multiple biological functions, including protein synthesis and gene regulation, making it pivotal in fetal development.
- The focus of this paper is the distribution of dehydrogenase enzymes related to the metabolism of glycogen, lipids, and RNA in each of the primary placental types. Dehydrogenase enzymes are responsible for oxidizing molecules by removing hydrogen atoms, a process central to metabolism.
- Beyond this, the study makes deductions about the function of the metabolic pathways demonstrated in these tissues. The researchers aim to correlate this with previous descriptions of lipid and RNA distributions.
Significance of the Research
This research is essential as it contributes to an in-depth understanding of the intra-uterine metabolic environment. By providing detailed insights into the metabolic pathways of essential substances in pregnancy-related tissues, this paper can potentially inform the development of therapeutic interventions and strategies to manage pregnancy complications. Moreover, it builds on previous foundational work, enriches scientific knowledge, and provides further directions for placental metabolism research.
Cite This Article
APA
Christie GA.
(1968).
Comparative histochemical studies on carbohydrate, lipid and RNA metabolism in the placenta and foetal membranes.
J Anat, 103(Pt 1), 91-112.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Carnivora
- Cats
- Chickens
- Decidua / metabolism
- Dogs
- Endoderm / metabolism
- Extraembryonic Membranes / enzymology
- Extraembryonic Membranes / metabolism
- Female
- Glycogen / metabolism
- Guinea Pigs
- Histocytochemistry
- Horses
- Humans
- Lipid Metabolism
- Oxidoreductases / metabolism
- Physiology, Comparative
- Placenta / enzymology
- Placenta / metabolism
- Pregnancy
- RNA / metabolism
- Rabbits
- Rats
- Sheep
- Trophoblasts / metabolism
References
This article includes 15 references
- Bulmer D, Dickson AD. The fibrinoid capsule of the rat placenta and the disappearance of the decidua.. J Anat 1961 Jul;95(Pt 3):300-10.
- Christie GA. Comparative histochemical distribution of glycogen and alkaline phosphatases in the placenta.. Histochemie 1967;9(2):93-116.
- Kalina M, Gahan PB, Jones GR. An evaluation of the histochemical demonstration of certain pyridine nucleotide-linked dehydrogenases.. Nature 1965 Aug 7;207(997):647-8.
- WEBER J. The site of production of gonadotrophin in the placenta at term. A histo-chemical study.. Acta Obstet Gynecol Scand 1961;40:139-51.
- BOURDEL G, JACQUOT R. [Role of placenta in the anabolism of pregnant rats].. C R Hebd Seances Acad Sci 1956 Jan 23;242(4):552-5.
- STETTEN D Jr, STETTEN MR. Glycogen metabolism.. Physiol Rev 1960 Jul;40:505-37.
- DAVIES J, DEMPSEY EW, AMOROSO EC. The subplacenta of the guinea-pig: development, histology and histochemistry.. J Anat 1961 Oct;95(Pt 4):457-73.
- HAFEZ ES. UTERINE AND PLACENTAL ENZYMES; A REVIEW.. Acta Endocrinol (Copenh) 1964 Jun;46:217-29.
- Botte V, Materazzi G, Chieffi G. Histochemical distribution of 3-beta-hydroxysteroid dehydrogenase and 17-alpha-and 17-beta-hydroxysteroid dehydrogenases in the placenta and foetal membranes of the rat.. J Endocrinol 1966 Feb;34(2):179-83.
- Ferguson MM, Christie GA. Distribution of hydroxysteroid dehydrogenases in the placentae and foetal membranes of various mammals.. J Endocrinol 1967 Jul;38(3):291-306.
- MAHLER HR, WITTENBERGER MH, BRAND L. Biochemical studies of the developing avian embryo. II. Enzymes of the citric acid cycle.. J Biol Chem 1958 Oct;233(4):770-82.
- HUGGETT AS. Carbohydrate metabolism in the placenta and foetus.. Br Med Bull 1961 May;17:122-6.
- DEANE HW, RUBIN BL, DRIKS EC, LOBEL BL, LEIPSNER G. Trophoblastic giant cells in placentas of rats and mice and their probable role in steroid-hormone production.. Endocrinology 1962 Mar;70:407-19.
- WIMSATT WA. Observations on the morphogenesis, cytochemistry, and significance of the binocleate giant cells of the placenta of ruminants.. Am J Anat 1951 Sep;89(2):233-81.
- Lambson RO. An electron microscopic visualization of transport across rat visceral yolk sac.. Am J Anat 1966 Jan;118(1):21-52.
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