[Comparative studies on clearance determination in horses].
Abstract: Results of comparative tests with several clearance methods on a total of 16 horses are reported.
The mean value calculated for endogenous creatinine clearance is 72.1±9.0, for total inulin clearance (from volume of distribution and elimination constant) 66.6±6.5 and for renal inulin clearance (with falling blood level and urine collection periods) 69.4±11.1 ml - min-1 - m-2.
The sodium clearance averages 0.12±0.09, the potassium clearance 38.1±12.4 ml - min-1 - m-2.
The results are discussed taking into account the different methods, and the possibility of using indirect clearance determination in large animals is pointed out.
Translated with DeepL.com (free version)
Publication Date: 1956-01-01 PubMed ID: 13349391DOI: 10.1007/BF00373932Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article presents a comparative analysis of various clearance methods on 16 horses and emphasizes the potential benefits of using indirect clearance determination for large animals.
Overview of the Research
- The study focused on analyzing different clearance methods on horses and how their results compare. Clearance is a measure of the ability of the kidney to remove substances from the blood, in this case, endogenous creatinine, inulin, sodium, and potassium.
- The researchers conducted study on 16 horses.
- The ultimate goal of the study is to ascertain the feasibility and potential benefits of using indirect clearance determination methods for large animals such as horses.
Major Findings
- Endogenous creatinine clearance was found to have a mean value of 72.1±9.0. Creatinine is a waste product produced by your muscles, and it is usually filtered out by the kidneys. The clearance rate can be used to assess kidney function.
- Total inulin clearance had a mean value of 66.6±6.5 and for renal inulin clearance the value was 69.4±11.1 ml-minute-1-m-2. Inulin is a type of sugar that human body doesn’t use for energy. It is often used in tests to measure kidney function because it gets filtered out by the kidneys without being reabsorbed or metabolized.
- The average sodium and potassium clearances were found to be 0.12±0.09 and 38.1±12.4 ml-minute-1-m-2 respectively. Sodium and potassium are electrolytes that help regulate fluids levels, nerve signals and muscle contractions in the body. Their clearance values can also indicate kidney functionality.
Comparison of Methods and Discussion
- The paper conducted a discussion on their findings in light of the different methods used.
- In particular, the study focused on and pointed out the potential of using indirect clearance determination for large animals.
Implications of the Study
- This research is significant as it highlights the potential of using indirect clearance determination methods for large animals, a useful tool for monitoring the renal health or functionality of these animals.
- The method may be of importance to veterinarians and researchers in charge of monitoring and maintaining the health of large animals such as horses.
Cite This Article
APA
KETZ HA, VOGEL G, LANGE M, HEYM E.
(1956).
[Comparative studies on clearance determination in horses].
Pflugers Arch Gesamte Physiol Menschen Tiere, 262(5), 425-430.
https://doi.org/10.1007/BF00373932 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Horses / physiology
- Kidney Function Tests
References
This article includes 16 references
- MOREL F. [The modalities of excretion of potassium by the kidney; experimental study with radiopotassium in the rabbit].. Helv Physiol Pharmacol Acta 1955;13(3):276-94.
- DUTZ H. [Kidney function test with clearance-method in constant and decreasing plasma level].. Z Gesamte Inn Med 1952 Jul 1;7(13):615-19.
- SCHMIDT-NIELSEN B. Excretion of endogenous and exogenous creatinine and of mannitol in the kangaroo rat.. Am J Physiol 1954 Jul;178(1):177-81.
- HARE RS, HARE K. Measurement of glomerular filtration rate in the dog.. Proc Soc Exp Biol Med 1954 Oct;87(1):119-21.
- JOSEPHSON B, KALLAS J. Inulin and creatinine clearance of unanaesthetized rabbits.. Acta Physiol Scand 1953 Dec 31;30(1):1-10.
- CHINARD FP. Comparative renal excretions of glomerular substances following instantaneous injection into a renal artery.. Am J Physiol 1955 Mar;180(3):617-9.
- MANDEL MJ, VIDT DG, SAPIRSTEIN LA. Disappearance of para-amino hippuric acid from the plasma of the dog after single intravenous injection.. Am J Physiol 1955 Sep;182(3):428-32.
- JOSEPHSON B, GRIEG A, KAKOSSAIOS G, KALLAS J. Renal tubular excretion from high plasma levels of para-aminohippurate (PAH) and diodrast (D) in unanaesthetized rabbits.. Acta Physiol Scand 1953 Dec 31;30(1):11-21.
- DOST FH. [Half value time and total clearance].. Z Gesamte Inn Med 1954 Jun 1;9(11):546-51.
- NUSSGENS H. [The usefulness of simplified clearance method as kidney function tests].. Klin Wochenschr 1954 Jun 1;32(21-22):491-5.
- ROSCOE MH. The endogenous creatinine clearance in normal subjects.. J Clin Pathol 1954 Nov;7(4):327-9.
- LANGECKER H, KUSCHINSKY G. [Diuresis, filtration and secretion of the kidney under the influence of various pharmaceuticals; Influence of atropine on the water and chloride excretion of the rat under various loads].. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 1947 Oct;204(6).
- PARRY HB, TAYLOR WH. Renal clearances of creatinine and p-amino-hippurate in normal pregnancy and toxaemia of pregnancy in the sheep.. J Physiol 1955 Mar 28;127(3):54-5P.
- Dick A, Davies CE. Measurement of the Glomerular Filtration Rate and the Effective Renal Plasma Flow Using Sodium Thiosulphate and p-Amino-Hippuric Acid.. J Clin Pathol 1949 Feb;2(1):67-72.
- KLAUS D, SEIFERT B, STRIPECKE W. [Comparative studies on the methodology of renal clearance].. Z Gesamte Inn Med 1955 Oct 1;10(19):918-24.
- BERLINER RW. The kidney.. Annu Rev Physiol 1954;16:269-304.
Citations
This article has been cited 1 times.- HEYM E, KRAMER E, VOGEL G. [Mechanism of potassium excretion in artificially perfused amphbian kidney]. Pflugers Arch Gesamte Physiol Menschen Tiere 1956 Sep 30;263(3):357-63.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
