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Home / Equine Research Bank / J Vet Intern Med / Comparative study of the bronchodilator efficacy and adverse...
Journal of veterinary internal medicine2024; doi: 10.1111/jvim.17057

Comparative study of the bronchodilator efficacy and adverse effects of salbutamol and hyoscine butylbromide in horses with severe asthma.

Abstract: Salbutamol and hyoscine butylbromide (HBB) are commonly used bronchodilators in horses with severe asthma (SA). Objective: To compare the bronchodilation potency, duration, and adverse effects of salbutamol and HBB in SA. Methods: Six horses in exacerbation of SA. Methods: The effects of inhaled salbutamol (1000 μg) and HBB (150 mg, IV) were compared in a randomized, blinded, crossover experiment. Lung function, intestinal borborygmi and heart rate were assessed before and sequentially until 180 minutes after drug administration, and analyzed with 2-way repeated-measures ANOVA and Dunnett's multiple comparison tests. Results: Both treatments caused a similar improvement in lung function. Pulmonary resistance and reactance returned to baseline values within 30 minutes after HBB administration, whereas salbutamol improved reactance until 180 minutes (mean improvement at 180 minutes of 0.040 Kpa/L/s, 95% CI = 0.004 to 0.076; P = .02 for salbutamol and of 0.009 Kpa/L/s, 95% CI = -0.028 to 0.045; P = .98 for HBB for the resistance at 3 Hz and of 0.040 Kpa/L/s, 95% CI = 0.007 to 0.074; P = .01 for salbutamol and of 0.009 Kpa/L/s, 95% CI = -0.024 to 0.042; P = .97 for HBB for the reactance at 7 Hz). From 5 to 30 minutes after HBB administration, the heart rate accelerated (mean increase of 3.3 beats per minute, 95% CI = -6.6 to 13.1; P = .92 for salbutamol, and of 13.0 beats per minute, 95% CI = 3.6 to 22.4; P = .002 for HBB at 30 minutes) and the gut sounds decreased (mean reduction of 1.3, 95% CI = -0.1 to 2.8; P = .09 for salbutamol and of 2.8 for the gastrointestinal auscultation score, 95% CI = 1.4 to 4.3; P < .0001 for HBB at 30 minutes). Conclusions: Both drugs have a similar bronchodilator potency but with a longer duration for salbutamol. Gastrointestinal and cardiovascular effects were noted only with HBB, suggesting the preferential use of salbutamol to relieve bronchoconstriction in horses with asthma.
© 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2024-04-12 PubMed ID: 38609079DOI: 10.1111/jvim.17057Google Scholar: Lookup
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Summary

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The research compares the bronchodilation effects and potential side effects of two commonly used treatments, salbutamol and hyoscine butylbromide (HBB), on horses suffering from severe asthma. The results suggest that both drugs are effective in treating asthma but salbutamol has a longer-lasting impact while HBB may induce cardiovascular and gastrointestinal side effects.

Study Methodology

  • The researchers started with six horses showing signs of severe asthma exacerbation for this randomized, blinded and crossover experiment.
  • Two different treatments were administered in the form of inhaled salbutamol (1000 μg) and HBB (150 mg, IV).
  • Outcome measures such as lung function, intestinal sounds (borborygmi) and heart rate were evaluated before and at various time points up to 180 minutes after drug administration.
  • Data was statistically analyzed with 2-way repeated-measures ANOVA and Dunnett’s multiple comparison tests.

Study Findings

  • Both salbutamol and HBB treatments demonstrated a similar improvement in lung function. However, salbutamol had a more sustained effect on the lung’s reactance (a measure of lung function), maintaining an improvement until 180 minutes post-administration.
  • After HBB administration, lung resistance and reactance returned to baseline values within 30 minutes.
  • In terms of side effects, heart rate quickened and gut sounds reduced between 5 to 30 minutes after HBB administration. These cardiovascular and gastrointestinal side effects weren’t observed with salbutamol administration.

Conclusions

  • While both drugs showed similar bronchodilation potencies, the duration of effect was longer for salbutamol.
  • Because of the cardiovascular and gastrointestinal side effects exhibited with HBB, the study’s findings suggest a preference for using salbutamol to alleviate bronchoconstriction in horses with severe asthma.

Cite This Article

APA
Mozo Vives B, Mainguy-Seers S, Lavoie JP. (2024). Comparative study of the bronchodilator efficacy and adverse effects of salbutamol and hyoscine butylbromide in horses with severe asthma. J Vet Intern Med. https://doi.org/10.1111/jvim.17057

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English

Researcher Affiliations

Mozo Vives, Berta
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, University of Montreal, St-Hyacinthe, Q, Canada.
Mainguy-Seers, Sophie
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, University of Montreal, St-Hyacinthe, Q, Canada.
Lavoie, Jean-Pierre
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, University of Montreal, St-Hyacinthe, Q, Canada.

Grant Funding

  • Fonds du Centenaire (Intern Funder), Faculty of Veterinary Medicine of the University of Montreal
  • Fonds en Santu00e9 u00c9quine (Intern Funder), Faculty of Veterinary Medicine of the University of Montreal

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