Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular fluids of vertebrates.
Abstract: A method using electrothermal atomic absorption spectroscopy was developed for the determination of copper (Cu) concentration in the cornea, iris, and lens of a variety of species, including dog, cat, rabbit, horse, and toad. Previously described methods were used to determine Cu in aqueous and vitreous humor. There was little difference between copper levels in the same tissue or fluid across the species. However, there were age and pathology-related changes in Cu concentration of the aqueous humor, cornea, and lens. In the groups of older dogs, the Cu concentration of the aqueous humor and cornea is significantly lower than the two younger groups. In both the dog and rabbit, lenses from young animals have the lowest copper concentration which increases and then finally decreases with age. Canine hypermature cataracts have a significantly higher copper concentration than control dogs of all age groups. There was no correlation between Cu concentration in the intraocular fluids and the cataractous lenses taken from the same eye. The role such an increase in lenticular Cu concentration may play in cataractogenesis needs to be explored.
Publication Date: 1986-01-01 PubMed ID: 3082599DOI: 10.3109/02713688608995168Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research presents a method to determine the concentration of copper in the eye tissues and fluids of various vertebrates, including dogs, cats, horses, and rabbits. The findings reveal variations in this concentration based on age and certain health conditions, such as cataracts.
Methodology
- The researchers developed a method using electrothermal atomic absorption spectroscopy. This was utilized to determine the concentrations of copper (Cu) in the cornea, iris, and lens of various animal species.
- Previous methods were employed to identify Cu concentrations in the aqueous and vitreous humor, which are types of intraocular fluid.
Findings
- Overall, there was little variation in copper levels in the same tissue or fluid across the different species studied. This suggests that copper concentration maintains a consistent level across different types of vertebrates.
- However, important variations showed up based on age and certain health conditions. For example, in older dogs, the concentration of Cu in the aqueous humor and cornea was significantly lower than in younger dogs.
- Interestingly, the pattern of Cu concentration across different ages was found to increase and then decrease. The lenses from young animals had the lowest copper concentration, which rose and eventually fell as the animals aged.
- In cases of hypermature cataracts in dogs, the concentration of Cu was significantly higher than in control dogs of all age groups.
Implications
- The study couldn’t find any correlation between Cu concentration in the intraocular fluids and the cataractous lenses when taken from the same eye.
- The unexpected elevation in copper concentrations in the lenses of cataract-affected dogs suggests there might be an unknown role the element plays in cataract development.
- The researchers concluded that further exploration is needed into this possible connection between increased copper concentration and cataract formation.
Cite This Article
APA
Cook CS, McGahan MC.
(1986).
Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular fluids of vertebrates.
Curr Eye Res, 5(1), 69-76.
https://doi.org/10.3109/02713688608995168 Publication
Researcher Affiliations
MeSH Terms
- Age Factors
- Animals
- Aqueous Humor / analysis
- Bufo marinus
- Cataract / metabolism
- Cats
- Copper / analysis
- Cornea / analysis
- Dogs
- Horses
- Iris / analysis
- Lens, Crystalline / analysis
- Rabbits
- Vitreous Body / analysis
Grant Funding
- EY04755 / NEI NIH HHS
- EY04900 / NEI NIH HHS
Citations
This article has been cited 5 times.- Micun Z, Falkowska M, Młynarczyk M, Kochanowicz J, Socha K, Konopińska J. Levels of Trace Elements in the Lens, Aqueous Humour, and Plasma of Cataractous Patients-A Narrative Review. Int J Environ Res Public Health 2022 Aug 20;19(16).
- Siddiqui TA, Zafar S, Iqbal N, Nadeem A, Zaidi Z, Alavi SH. Effect of Kohl-Chikni Dawa - a compound ophthalmic formulation of Unani medicine on naphthalene-induced cataracts in rats. BMC Complement Altern Med 2002 Dec 29;2:13.
- Pulido JS. Experimental nonenzymatic glycosylation of vitreous collagens occurs by two pathways. Trans Am Ophthalmol Soc 1996;94:1029-72.
- Cheng RZ, Uchida K, Kawakishi S. Selective oxidation of histidine residues in proteins or peptides through the copper(II)-catalysed autoxidation of glucosone. Biochem J 1992 Jul 15;285 ( Pt 2)(Pt 2):667-71.
- Balaji M, Sasikala K, Ravindran T. Copper levels in human mixed, nuclear brunescence, and posterior subcapsular cataract. Br J Ophthalmol 1992 Nov;76(11):668-9.
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