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Equine veterinary journal1995; 27(6); 440-447; doi: 10.1111/j.2042-3306.1995.tb04425.x

Corneal stromal abscesses in the horse: a review of 24 cases.

Abstract: The medical records of 24 horses with corneal stromal abscesses were reviewed. Twenty of the horses initially presented with a corneal ulcer, corneal opacity, or evidence of ocular pain. All of the horses were treated with topical antibiotics prior to referral. Most had also been treated with topical atropine sulphate and systemic flunixin meglumine. Ophthalmic examinations revealed focal, yellow-white corneal opacities, corneal vascularisation and evidence of iridocyclitis. Nine of the horses were treated primarily medically as the initial response to topical and systemic medication was rapid. Fifteen horses were treated both medically and surgically. Surgical treatment was undertaken when corneal rupture was imminent, the iridocyclitis was intractable or when there was minimal response to intensive medical therapy. The surgical procedure performed in most cases was a deep keratectomy with a conjunctival pedicle flap. Intraoperative specimens for cytology, culture, and/or histopathology contributed to the aetiological diagnosis in 5 of 8 cases in which preoperative cytology and cultures were nondiagnostic. All horses, excluding one that was enucleated at presentation for iris prolapse, had vision at discharge.
Publication Date: 1995-11-01 PubMed ID: 8565941DOI: 10.1111/j.2042-3306.1995.tb04425.xGoogle Scholar: Lookup
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Summary

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This study reviews 24 cases of corneal stromal abscesses in horses. Despite initial treatments with topical antibiotics, most required further medical or surgical intervention. All the horses except for one retained their vision at discharge.

Participants and Initial Symptoms

  • The study looked at the medical records of 24 horses diagnosed with corneal stromal abscesses.
  • Majority of the horses (20 out of 24) initially presented with symptoms like corneal ulcer, corneal opacity or evidence of ocular pain.

Initial Treatment

  • For initial treatment, all the horses were treated with topical antibiotics.
  • Besides this, most of the horses had been treated with topical atropine sulphate and systemic flunixin meglumine.

Ophthalmic Examination Findings

  • Ophthalmic examinations of the horses revealed focal, yellow-white corneal opacities.
  • The examinations also revealed corneal vascularisation and evidence of iridocyclitis, which suggests inflammation of the iris and ciliary body.

Further Treatment

  • Among the total, nine of the horses were primarily treated medically as their initial response to topical and systemic medication was rapid.
  • The other 15 horses required both medical and surgical treatment. Surgical intervention was required when the corneal rupture seemed imminent, or the iridocyclitis was severe, or the response to intensive medical therapy was minimal.
  • The most common surgical procedure performed was a deep keratectomy with a conjunctival pedicle flap.

Outcome and Diagnosis

  • In 5 out of 8 cases where initial cytology and cultures were non-diagnostic, intraoperative specimens taken for cytology, culture, and/or histopathology helped achieve an etiological diagnosis.
  • Except for one horse that had been enucleated upon presentation because of iris prolapse, all other horses had vision when discharged from treatment.

Cite This Article

APA
Hendrix DV, Brooks DE, Smith PJ, Gelatt KN, Miller TR, Whittaker C, Pellicane C, Chmielewski N. (1995). Corneal stromal abscesses in the horse: a review of 24 cases. Equine Vet J, 27(6), 440-447. https://doi.org/10.1111/j.2042-3306.1995.tb04425.x

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 27
Issue: 6
Pages: 440-447

Researcher Affiliations

Hendrix, D V
  • Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
Brooks, D E
    Smith, P J
      Gelatt, K N
        Miller, T R
          Whittaker, C
            Pellicane, C
              Chmielewski, N

                MeSH Terms

                • Abscess / microbiology
                • Abscess / pathology
                • Abscess / veterinary
                • Administration, Topical
                • Animals
                • Anti-Bacterial Agents / administration & dosage
                • Anti-Bacterial Agents / therapeutic use
                • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
                • Aspergillosis / pathology
                • Aspergillosis / therapy
                • Aspergillosis / veterinary
                • Atropine / administration & dosage
                • Atropine / therapeutic use
                • Clonixin / administration & dosage
                • Clonixin / analogs & derivatives
                • Clonixin / therapeutic use
                • Corneal Diseases / microbiology
                • Corneal Diseases / pathology
                • Corneal Diseases / veterinary
                • Corneal Stroma / microbiology
                • Corneal Stroma / pathology
                • Corneal Stroma / surgery
                • Corynebacterium Infections / pathology
                • Corynebacterium Infections / therapy
                • Corynebacterium Infections / veterinary
                • Female
                • Horse Diseases / microbiology
                • Horse Diseases / pathology
                • Horse Diseases / therapy
                • Horses
                • Iridocyclitis / pathology
                • Iridocyclitis / therapy
                • Iridocyclitis / veterinary
                • Male
                • Mydriatics / administration & dosage
                • Mydriatics / therapeutic use
                • Retrospective Studies
                • Staphylococcal Infections / pathology
                • Staphylococcal Infections / therapy
                • Staphylococcal Infections / veterinary
                • Streptococcal Infections / pathology
                • Streptococcal Infections / therapy
                • Streptococcal Infections / veterinary

                Citations

                This article has been cited 8 times.
                1. Kuroda T, Knych HK, Noble GK, Minamijima Y, Leung GN, Nomura M, Mizobe F, Ishikawa Y, Kusano K, Toutain PL. A Meta-Analysis of International Flunixin Pharmacokinetics in Horses: Toward Regulatory Harmonization and Individualized Detection Times Using Bayesian Paradigm. Drug Test Anal 2026 Jan;18(1):32-50.
                  doi: 10.1002/dta.3961pubmed: 41137541google scholar: lookup
                2. Preston JF, Mustikka MP, Priestnall SL, Dunkel B, Fischer MC. Clinical features and outcomes of horses presenting with presumed equine immune mediated keratitis to two veterinary hospitals in the United Kingdom and Finland: 94 cases (2009-2021). Equine Vet J 2025 May;57(3):598-610.
                  doi: 10.1111/evj.14213pubmed: 39183684google scholar: lookup
                3. Mo PM, Picard J, Gummow B. The conjunctival fungal microflora of horses in a North Queensland tropical environment and their in vitro susceptibilities to antifungal agents. Vet Res Commun 2023 Sep;47(3):1641-1651.
                  doi: 10.1007/s11259-023-10119-9pubmed: 37022654google scholar: lookup
                4. Flores MM, Del Piero F, Habecker PL, Langohr IM. A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J Vet Diagn Invest 2020 May;32(3):382-388.
                  doi: 10.1177/1040638720912698pubmed: 32207378google scholar: lookup
                5. Mustikka MP, Grönthal TSC, Pietilä EM. Equine infectious keratitis in Finland: Associated microbial isolates and susceptibility profiles. Vet Ophthalmol 2020 Jan;23(1):148-159.
                  doi: 10.1111/vop.12701pubmed: 31364808google scholar: lookup
                6. Reed Z, Thomasy SM, Good KL, Maggs DJ, Magdesian KG, Pusterla N, Hollingsworth SR. Equine keratomycoses in California from 1987 to 2010 (47 cases). Equine Vet J 2013 May;45(3):361-6.
                7. Hartley C. Treatment of corneal ulcers: when is surgery indicated?. J Feline Med Surg 2010 May;12(5):398-405.
                  doi: 10.1016/j.jfms.2010.03.013pubmed: 20417900google scholar: lookup
                8. Hartley C. Aetiology of corneal ulcers assume FHV-1 unless proven otherwise. J Feline Med Surg 2010 Jan;12(1):24-35.
                  doi: 10.1016/j.jfms.2009.12.004pubmed: 20123484google scholar: lookup