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[Cowpox viruses in Germany: an analysis of 5 cases in 1998].

Abstract: Five case reports on cowpox virus infections in cats, humans, and for the first time in a horse are presented. It becomes obvious that in most cases the diagnosis cowpox is suspected rather late, although fast and reliable diagnostic tools such as pathohistological examination and polymerase chain reaction are available. The threat of a zoonotic transmission mainly through cats is gaining importance. Although wild rodents have been claimed to be the reservoir and source for cowpox viruses in cats, very little is known about the epidemiology of cowpox virus. Based on the different genome organizations found in the German isolates, we conclude that various subtypes of cowpox virus are circulating in Germany at one time.
Publication Date: 1999-10-03 PubMed ID: 10507182
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  • English Abstract
  • Journal Article

Summary

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The research article discusses five cases of cowpox virus infections in cats, humans, and a horse in Germany in 1998 and concludes that different subtypes of the cowpox virus are currently circulating in the country.

Research Purpose and Approach

  • The authors aim to examine and report on five incidents of cowpox virus infections in cats, humans, and, for the first time, a horse within Germany over the course of 1998.
  • The research method predominantly involved the diagnosis of cowpox using pathohistological examination and polymerase chain reaction tools. These tools allowed for quick and competent diagnoses.

Findings and Observations

  • The research found that diagnoses of cowpox tend to be suspected rather late, even though rapid and reliable diagnostic tools are readily available.
  • It highlighted that the threat of zoonotic transmission (disease transfer from animals to humans) is escalating, primarily through cats.
  • The paper discussed the presumption that wild rodents serve as the reservoir and origin of cowpox viruses in cats. Nevertheless, the actual epidemiology of cowpox virus—its incident rates, distribution, causes, and control—is not well-understood or extensively studied.

Conclusions

  • Based on the differences in genome organizations identified in the German isolates during this research, the authors concluded that various subtypes of the cowpox virus were circulating in Germany concurrently.
  • This finding underpins the significance of continued surveillance and research into this evolving health threat within Germany and potentially elsewhere.

Cite This Article

APA
Pfeffer M, Burck G, Meyer H. (1999). [Cowpox viruses in Germany: an analysis of 5 cases in 1998]. Berl Munch Tierarztl Wochenschr, 112(9), 334-338.

Publication

ISSN: 0005-9366
NlmUniqueID: 0003163
Country: Germany
Language: ger
Volume: 112
Issue: 9
Pages: 334-338

Researcher Affiliations

Pfeffer, M
  • Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin der Tiermedizinischen Fakultät der Ludwig-Maximilians-Universität München. Martin.Pfeffer@micro.vetmed.uni-muenchen.de
Burck, G
    Meyer, H

      MeSH Terms

      • Animals
      • Cat Diseases / epidemiology
      • Cat Diseases / virology
      • Cats
      • Cowpox / epidemiology
      • Cowpox / veterinary
      • Germany / epidemiology
      • Horse Diseases / epidemiology
      • Horse Diseases / virology
      • Horses
      • Humans
      • Zoonoses

      Citations

      This article has been cited 5 times.
      1. Bruneau RC, Tazi L, Rothenburg S. Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats. Biomolecules 2023 Feb 8;13(2).
        doi: 10.3390/biom13020325pubmed: 36830694google scholar: lookup
      2. MacNeill AL. Comparative Pathology of Zoonotic Orthopoxviruses. Pathogens 2022 Aug 9;11(8).
        doi: 10.3390/pathogens11080892pubmed: 36015017google scholar: lookup
      3. Ehmann R, Brandes K, Antwerpen M, Walter M, V Schlippenbach K, Stegmaier E, Essbauer S, Bugert J, Teifke JP, Meyer H. Molecular and genomic characterization of a novel equine molluscum contagiosum-like virus. J Gen Virol 2021 Mar;102(3).
        doi: 10.1099/jgv.0.001357pubmed: 31922947google scholar: lookup
      4. Prkno A, Hoffmann D, Goerigk D, Kaiser M, van Maanen ACF, Jeske K, Jenckel M, Pfaff F, Vahlenkamp TW, Beer M, Ulrich RG, Starke A, Pfeffer M. Epidemiological Investigations of Four Cowpox Virus Outbreaks in Alpaca Herds, Germany. Viruses 2017 Nov 18;9(11).
        doi: 10.3390/v9110344pubmed: 29156539google scholar: lookup
      5. Miranzadeh Mahabadi H, Noyce RS, Evans DH, Power C. Neurological complications of Orthopoxvirus infections: neurotropism and neurovirulence. Brain 2025 Oct 3;148(10):3445-3455.
        doi: 10.1093/brain/awaf181pubmed: 40372132google scholar: lookup