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Journal of biochemical and molecular toxicology2021; 36(2); e22955; doi: 10.1002/jbt.22955

Data on multiple regression analysis between boron, nickel, arsenic, antimony, and biological substrates in horses: The role of hematological biomarkers.

Abstract: The objective of this study was to evaluate the biomarkers of exposure to boron, nickel, arsenic, and antimony in an industrial region, evaluating the bioaccumulation in biological substrates and the correlation with biomarkers such as hematological parameters. Through indication of the accumulation of some minerals in the horse's biological substrates reflects environmental pollution. Moreover, an additional aim of the study was to show whether these contaminants have an influence on the hematological parameters in horses. Blood, serum, mane, and tail samples from 20 horses from an industrial area were analyzed to determine boron (B), nickel (Ni), arsenic (As), antimony (Sb) concentration. Hematological parameters (red blood cell [RBC], white blood cells [WBC], hemoglobin [Hb], hematocrit [Hct], mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], platelet [PLT]) as a biomarker of blood in relation to the bioaccumulation of these elements were analyzed also. Descriptive statistical analysis was performed and single regression analysis (Pearson) and multiple regression analysis (p < 0.05) between blood factors, As, B, Ni, and Sb concentrations, and for each mineral in different substrate, respectively. Results showed a significant correlation between tail and mane concentrations with serum and blood for boron concentration (r = -1 p < 0.05). No significant correlation between sample (feed, hay, mane, tail, and water) concentrations and As, Ni, and Sb were found. A significantly negative correlation with blood parameters (r = -1 p < 0.05) was observed in Boron concentration for mane and tail. This suggests that the mane and tail may be a potential means to investigate suspected exposure to excessive levels of trace minerals.
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Publication Date: 2021-11-10 PubMed ID: 34755932DOI: 10.1002/jbt.22955Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study evaluated the biomarkers of exposure to certain minerals in horses from an industrial region, assessing the accumulation levels within the animals and their impact on the horses’ red and white blood cells, hemoglobin, platelets, etc. The mane and tail samples were useful in determining excessive exposure to trace minerals.

Objective of the Research

  • The study sought to investigate the biomarkers indicating exposure to boron, nickel, arsenic, and antimony in horses from an industrial region. This included studying the concentration of these minerals in the horses’ biological substrates such as blood, serum, mane and tail samples.
  • It aimed to establish whether the bioaccumulation of these contaminants affects the horses’ hematological parameters, which include red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelets (PLT).

Methodology and Analysis

  • The study involved examining samples from 20 horses from an industrial area. The samples were tested to determine levels of boron, nickel, arsenic, and antimony.
  • Data collection included both single regression analysis (Pearson) and multiple regression analysis to investigate the correlation between blood factors and the different minerals’ concentrations.

Findings of the Study

  • The study showed a significant correlation between the concentration levels of boron found in tail and mane samples and that in blood and serum.
  • However, it was unable to find a significant correlation between samples of substances consumed by the horses (feed, hay, and water) and the concentrations of arsenic, nickel, and antimony.
  • The research found a negatively significant correlation between boron concentration in mane and tail samples and blood parameters. This indicates that horse manes and tails could potentially be a good source for investigations into suspected exposure to excessive levels of crucial trace minerals.

Cite This Article

APA
Giannetto C, Fazio F, Nava V, Arfuso F, Piccione G, Coelho C, Gugliandolo E, Licata P. (2021). Data on multiple regression analysis between boron, nickel, arsenic, antimony, and biological substrates in horses: The role of hematological biomarkers. J Biochem Mol Toxicol, 36(2), e22955. https://doi.org/10.1002/jbt.22955

Publication

Journal of biochemical and molecular toxicology
ISSN: 1099-0461
NlmUniqueID: 9717231
Country: United States
Language: English
Volume: 36
Issue: 2
Pages: e22955

Researcher Affiliations

Giannetto, Claudia
  • Department of Veterinary Science, University of Messina, Messina, Italy.
Fazio, Francesco
  • Department of Veterinary Science, University of Messina, Messina, Italy.
Nava, Vincenzo
  • BioMorf Department, University of Messina, Messina, Italy.
Arfuso, Francesca
  • Department of Veterinary Science, University of Messina, Messina, Italy.
Piccione, Giuseppe
  • Department of Veterinary Science, University of Messina, Messina, Italy.
Coelho, Clarisse
  • Faculty of Veterinary Medicine, Lusofona University, Lisbon, Portugal.
Gugliandolo, Enrico
  • Department of Veterinary Science, University of Messina, Messina, Italy.
Licata, Patrizia
  • Department of Veterinary Science, University of Messina, Messina, Italy.

MeSH Terms

  • Animals
  • Antimony / blood
  • Arsenic
  • Biomarkers / blood
  • Boron / blood
  • Hematocrit
  • Horses / blood
  • Nickel / blood

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Citations

This article has been cited 4 times.
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  3. Alaryani FS. Myricetin ameliorates arsenic-induced hematological changes, immune dysfunction, oxidative stress, hepatic and renal injuries and promotes inflammatory genes in rats. Open Vet J 2024 Jul;14(7):1677-1688.
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