Disease remission in a horse with EHV-5-associated lymphoma.
Abstract: No abstract available
Publication Date: 2013-03-04 PubMed ID: 23458852DOI: 10.1111/jvim.12050Google Scholar: Lookup
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Summary
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The research article discusses the case of a 12-year-old Quarter Horse that had a three-year history of enlarged lymph nodes under the lower jaw, which resulted in full remission after surgery and chemotherapy. Specifically, the article explores how the horse was diagnosed with equine herpesvirus-5 (EHV-5) associated lymphoma.
Case Presentation
- The horse had been suffering from enlarged submandibular lymph nodes for three years which intermittently produced purulent exudate. Previous treatments with antibiotics showed only temporary responses.
- Despite the enlarged lymph nodes, the horse did not show any fever, nasal discharge, or coughing, and continued to eat and drink normally. Physical health check-up did not reveal any irregularities apart from the swollen lymph nodes and severe gingivitis.
- An initial biopsy of the swollen lymph node was performed revealing T-cell rich, B-cell lymphoma.
Pre-surgery Evaluations
- A week before surgery, the horse’s blood count and fibrinogen were found to be normal. However, the protein electrophoresis showed panhypoglobulinemia and low Immunoglobulin M concentration.
- Thoracic ultrasound and radiographs did not show any abnormalities. Immunophenotyping of the whole blood showed an increase in CD8+ lymphocytes, indicating the presence of neoplastic cells.
Surgery and Post-Operative Treatment
- Surgery was performed to remove the entire chain of lymph nodes from the horse. Histopathological examination of the removed lymph nodes confirmed the presence of T-cell rich, B-cell lymphoma.
- The horse was discharged after surgery with an instruction for administering an antibiotic and anti-inflammatory treatment regimen.
Chemotherapy and Recovery
- Chemotherapy was initiated one month after surgery and was conducted by the horse’s regular veterinarian. Due to financial constraints, the chemotherapy administration was limited to one month.
- The horse showed no adverse effects to the chemotherapy medications and complete blood count was performed before each chemotherapy dose confirming the horse’s tolerance to the therapy.
- The horse showed positive signs of recovery and achieved a full remission from lymphoma.
Cite This Article
APA
Vander Werf K, Davis E.
(2013).
Disease remission in a horse with EHV-5-associated lymphoma.
J Vet Intern Med, 27(2), 387-389.
https://doi.org/10.1111/jvim.12050 Publication
Researcher Affiliations
- Clinical Sciences-Large Animal, University of Illinois, Champaign-Urbana, IL 61802, USA. kvanderw@illinois.edu
MeSH Terms
- Animals
- Female
- Herpesviridae Infections / pathology
- Herpesviridae Infections / therapy
- Herpesviridae Infections / veterinary
- Herpesvirus 1, Equid / isolation & purification
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horse Diseases / virology
- Horses
- Lymphoma / pathology
- Lymphoma / therapy
- Lymphoma / veterinary
- Lymphoma / virology
- Treatment Outcome
Citations
This article has been cited 11 times.- Silva GF, Ribeiro TE, Cunha R, Salas PB, Guimarães T, Ribeiro MR, Barros G, Carvalho F, Mesquita JR, Amorim I. A case of equine multicentric lymphoma: Clinical, microscopical, and molecular findings. Open Vet J 2024 May;14(5):1294-1301.
- Acevedo HD, Hassebroek AM, Leventhal HR, Duhamel GE, Carvallo FR. Colonic T-cell-rich, large B-cell lymphoma associated with equid herpesvirus 5 infection and secondary trans-colonic fistula in a horse. J Vet Diagn Invest 2023 May;35(3):272-277.
- Drozdzewska K, Gehlen H. Markers for internal neoplasia in the horse. Vet Med Sci 2023 Jan;9(1):132-143.
- Wang L, Unger L, Sharif H, Eriksson S, Gerber V, Rönnberg H. Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma. BMC Mol Cell Biol 2021 Dec 14;22(1):59.
- Torrent A, Kilcoyne I, Johnson A, Affolter VK, Berryhill E, Aleman M. An atypical presentation of multi-systemic B-cell lymphoma in a horse. Can Vet J 2019 Mar;60(3):300-304.
- Van Cleemput J, Poelaert KCK, Laval K, Nauwynck HJ. Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models. Vet Res 2019 Feb 18;50(1):13.
- Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Can Vet J 2019 Jan;60(1):33-40.
- Luethy D, Frimberger AE, Bedenice D, Byrne BS, Groover ES, Gardner RB, Lewis T, MacDonald VS, Proctor-Brown L, Tomlinson JE, Rassnick KM, Johnson AL. Retrospective evaluation of clinical outcome after chemotherapy for lymphoma in 15 equids (1991-2017). J Vet Intern Med 2019 Mar;33(2):953-960.
- Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. Gammaherpesvirus infections in equids: a review. Vet Med (Auckl) 2015;6:91-101.
- Smith FL, Watson JL, Spier SJ, Kilcoyne I, Mapes S, Sonder C, Pusterla N. Frequency of shedding of respiratory pathogens in horses recently imported to the United States. J Vet Intern Med 2018 Jul;32(4):1436-1441.
- Westerman TL, Poulsen KP, Schlipf JW Jr, Valentine BA. Neurotropic T-cell-rich B-cell lymphoma in a 14-year-old Morgan gelding. Can Vet J 2014 Apr;55(4):379-82.
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