Effect of a blend of magnesium oxide on Equine Squamous Gastric Disease in young trotter horses under training.
Abstract: Equine squamous gastric disease (ESGD), as part of the equine gastric ulcer syndrome (EGUS), are common in racing horses. The use of buffering feed supplements to treat and/or prevent gastric ulcers is an option to control this condition. Objective: The purpose of this study was to evaluate the effect of a 30-day supplementation with a blend of magnesium oxide (MgO) on ESGD scores in trotters under training. Methods: Forty-two young trotters were submitted to a gastroscopic evaluation to assess their ESGD score and were randomly assigned in a group supplemented with MgO or in a control group. After 30 days, a second evaluation by gastroscopy was performed. The effect of the MgO supplementation was assessed by comparing the evolution of the ESGD score in supplemented and control groups between day 0 and day 30. Results: The results confirm the high prevalence of EGUS in young Trotters. The supplementation significantly decreased the ESGD scoring in the supplemented group whereas the control group remain unchanged. Conclusions: The oral MgO supplementation was efficient to control ESGD in the population studied.
© 2023 The Korean Society of Veterinary Science.
Publication Date: 2023-11-30 PubMed ID: 38031523PubMed Central: PMC10694373DOI: 10.4142/jvs.23118Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Randomized Controlled Trial
- Veterinary
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study aims to establish the impact of a 30-day regimen of magnesium oxide dietary supplements on the prevalence of Equine Squamous Gastric Disease (ESGD) in trotter racing horses.
Background
- Equine Squamous Gastric Disease (ESGD) is a type of equine gastric ulcer syndrome (EGUS) commonly diagnosed in racing horses.
- The condition causes ulcers in the horse’s stomach, which could affect the horse’s health and racing performance.
- Feeding supplements that buffer the stomach’s acid is a prevalent practice for managing this condition. Yet, scientific proof of their efficacy is needed.
Objective
- This research aims to examine the effect of supplementing the diet of trotter horses under training with magnesium oxide (MgO), on ESGD rates over a 30-day period.
Methodology
- 42 young trotter horses were recruited for the study and underwent initial gastroscopic examinations to determine their ESGD score.
- The horses were then randomly divided into two groups: one group was provided with MgO supplementation, while the other group acted as the control, receiving no such supplementation.
- After 30 days, a second gastroscopic exam was conducted to track changes in each horse’s ESGD score.
- The effectiveness of MgO supplementation was gauged by comparing the evolution of the ESGD scores in the MgO-supplemented group and the control group from day 0 to day 30.
Results
- The study confirmed the high incidence of EGUS in young trotters.
- The addition of magnesium oxide was found to significantly reduce the ESGD score in the test group sampled, but the control group’s scores remained the same.
Conclusion
- This study concluded that oral supplementation with magnesium oxide can effectively manage ESGD in the studied young trotter horses.
Cite This Article
APA
Leleu C, Couroucé A.
(2023).
Effect of a blend of magnesium oxide on Equine Squamous Gastric Disease in young trotter horses under training.
J Vet Sci, 24(6), e87.
https://doi.org/10.4142/jvs.23118 Publication
Researcher Affiliations
- Equi-Test, Grez-en-Bouère 53290, France. leleuclaire@sfr.fr.
- BIOTARGEN, Université de Caen Normandie, 14000 Caen, France.
- ONIRIS, CISCO-ONIRIS, Route de Gachet, Nantes Cedex 44307, France.
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / veterinary
- Gastroscopy / methods
- Gastroscopy / veterinary
- Horse Diseases / drug therapy
- Horse Diseases / prevention & control
- Horses
- Magnesium Oxide / pharmacology
- Stomach Ulcer / veterinary
Grant Funding
- Timab Magnesium
Conflict of Interest Statement
The authors declare no conflicts of interest.
References
This article includes 22 references
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--equine gastric ulcer syndrome in adult horses.. J Vet Intern Med 2015;29(5):1288–1299.
- Andrews FM, Sifferman RL, Bernard W, Hughes FE, Holste JE, Daurio CP. Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses.. Equine Vet J 1999;31(29):81–86.
- Murray MJ, Haven ML, Eichorn ES, Zhang D, Eagleson J, Hickey GJ. Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses.. Equine Vet J 1997;29(6):425–429.
- Vokes J, Lovett A, Sykes B. Equine gastric ulcer syndrome: an update on current knowledge.. Animals (Basel) 2023;13(7):1261.
- Huff NK, Auer AD, Garza F Jr, Keowen ML, Kearney MT, McMullin RB. Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses.. J Vet Intern Med 2012;26(5):1186–1191.
- Murray MJ, Grady TC. The effect of a pectin-lecithin complex on prevention of gastric mucosal lesions induced by feed deprivation in ponies.. Equine Vet J 2002;34(2):195–198.
- Venner M, Lauffs S, Deegen E. Treatment of gastric lesions in horses with pectin-lecithin complex.. Equine Vet J 1999;31(29):91–96.
- Bach A, Guasch I, Elcoso G, Duclos J, Khelil-Arfa H. Modulation of rumen pH by sodium bicarbonate and a blend of different sources of magnesium oxide in lactating dairy cows submitted to a concentrate challenge.. J Dairy Sci 2018;101(11):9777–9788.
- Leno BM, LaCount SE, Ryan CM, Briggs D, Crombie M, Overton TR. The effect of source of supplemental dietary calcium and magnesium in the peripartum period, and level of dietary magnesium postpartum, on mineral status, performance, and energy metabolites in multiparous Holstein cows.. J Dairy Sci 2017;100(9):7183–7197.
- Colombo EA, Cooke RF, Araújo AC, Harvey KM, Pohler KG, Brandão AP. Supplementing a blend of magnesium oxide to feedlot cattle: effects on ruminal, physiological, and productive responses.. J Anim Sci 2022;100(1):skab375.
- Schaefer DM, Wheeler LJ, Noller CH, Keyser RB, White JL. Neutralization of acid in the rumen by magnesium oxide and magnesium carbonate.. J Dairy Sci 1982;65(5):732–739.
- Le Ruyet P, Tucker WB. Ruminal buffers: temporal effects on buffering capacity and pH of ruminal fluid from cows fed a high concentrate diet.. J Dairy Sci 1992;75(4):1069–1077.
- Rabuffo TS, Orsini JA, Sullivan E, Engiles J, Norman T, Boston R. Associations between age or sex and prevalence of gastric ulceration in Standardbred racehorses in training.. J Am Vet Med Assoc 2002;221(8):1156–1159.
- Dionne RM, Vrins A, Doucet MY, Paré J. Gastric ulcers in standardbred racehorses: prevalence, lesion description, and risk factors.. J Vet Intern Med 2003;17(2):218–222.
- Roy MA, Vrins A, Beauchamp G, Doucet MY. Prevalence of ulcers of the squamous gastric mucosa in standardbred horses.. J Vet Intern Med 2005;19(5):744–750.
- Jonsson H, Egenvall A. Prevalence of gastric ulceration in Swedish Standardbreds in race training.. Equine Vet J 2006;38(3):209–213.
- Bell NJ, Burget D, Howden CW, Wilkinson J, Hunt RH. Appropriate acid suppression for the management of gastro-oesophageal reflux disease.. Digestion 1992;51(Suppl 1):59–67.
- Suzuki H, Nishizawa T, Tsugawa H, Mogami S, Hibi T. Roles of oxidative stress in stomach disorders.. J Clin Biochem Nutr 2012;50(1):35–39.
- Liu M, Dudley SC Jr. Magnesium, oxidative stress, inflammation, and cardiovascular disease.. Antioxidants 2020;9(10):907.
- Mathew AA, Panonnummal R. ‘Magnesium’-the master cation-as a drug-possibilities and evidences.. Biometals 2021;34(5):955–986.
- Tandon R, Khanna HD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma.. Indian J Physiol Pharmacol 2004;48(1):115–118.
- Ige AO, Adewoye EO, Okwundu NC, Alade OE, Onuobia PC. Oral magnesium reduces gastric mucosa susceptibility to injury in experimental diabetes mellitus.. Pathophysiology 2016;23(2):87–93.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists