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Veterinary and animal science2023; 23; 100330; doi: 10.1016/j.vas.2023.100330

Effects of intra-articular administration of hyaluronic acid or platelet-rich plasma as a complementary treatment to arthroscopy in horses with osteochondritis dissecans.

Abstract: Although arthroscopy is the treatment of choice for horses with osteochondritis dissecans (OCD), it is not yet known whether intra-articular therapies in the postoperative period can bring any benefit to the recovery of these animals. This study evaluated the effects of the intra-articular application of platelet-rich plasma (PRP), hyaluronic acid (HA) or lactated Ringer's solution (LR) in horses with OCD undergoing arthroscopy. Eighteen male and female Brazilian Sport horses aged between 2 and 6 years were evaluated. All animals presented OCD fragments in the middle crest of the tibia. Ten days after surgery, animals were randomly distributed into three groups and received intra-articular application of PRP (n = 6), HA (n = 6), or LR (control group, n = 6). Clinical, radiographic, ultrasound and synovial fluid evaluations were performed on the day of surgery and after 10, 30 and 60 days. An increase in the thickness of the joint capsule was observed 30 days after surgery in the three groups evaluated. In the control group, there was significant improvement in the flexion test 30 and 60 days after surgery, and in the PRP group, there was worsening of this parameter in the same evaluations. In the control group, there was a reduction in the degree of synovial effusion, and in the PRP and HA groups, there was increased effusion. There was a significant increase in the number of leukocytes in the HA group. Intra-articular use of PRP or HA ten days after arthroscopy did not promote positive effects on the recovery of horses with OCD.
© 2024 The Authors. Published by Elsevier Ltd.
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Publication Date: 2023-12-23 PubMed ID: 38259325PubMed Central: PMC10801337DOI: 10.1016/j.vas.2023.100330Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigated the effects of certain therapies administered after arthroscopic surgery for horses with osteochondritis dissecans (OCD), a joint disorder. The therapies examined included platelet-rich plasma (PRP), hyaluronic acid (HA), and a control solution in a sample of Brazilian Sport horses. The results suggest that the additional treatments did not significantly improve the horses’ recovery.

Methodology

  • The researchers studied 18 Brazilian Sport horses suffering from OSD fragments in the crest of their tibia. The horses involved in the study were both males and females, ranging from 2 to 6 years of age.
  • A random allotment of these horses was then made into three groups, each receiving a different intra-articular application 10 days after arthroscopy: PRP, HA, or lactated Ringer’s solution (LR) as a control group.
  • The researchers then carried out clinical, radiographic, ultrasound, and synovial fluid evaluations on the day of surgery and after 10, 30, and 60 days.

Findings

  • 30 days post-surgery, all groups showed a thickening of the joint capsule.
  • In the control group, the flexion test results improved significantly 30 and 60 days after surgery. On the other hand, the PRP-treated group exhibited a worsening of flexion test parameters for the same time periods.
  • The study noted a reduction in the level of synovial effusion (fluid in the joint) in the control group, while the PRP and HA groups witnessed an increase.
  • There was a significant increase in the white blood cell count, indicating inflammation, in the HA group.

Conclusions

  • The results suggest that the intra-articular application of PRP or HA ten days after arthroscopy did not yield any positive effects on the recovery of horses with OCD.
  • This suggests other strategies for post-surgery care should be explored and tested to determine effective ways to boost recovery in horses undergoing OCD surgery.

The authors highlight the need for more research in this area to explore potential therapies that could prove beneficial in the post-operative recovery period for equine patients with this joint condition.

Cite This Article

APA
Pereira MF, Ribeiro G, Gonzales A, Arantes JA, Dória RGS. (2023). Effects of intra-articular administration of hyaluronic acid or platelet-rich plasma as a complementary treatment to arthroscopy in horses with osteochondritis dissecans. Vet Anim Sci, 23, 100330. https://doi.org/10.1016/j.vas.2023.100330

Publication

Veterinary and animal science
ISSN: 2451-943X
NlmUniqueID: 101694897
Country: Netherlands
Language: English
Volume: 23
Pages: 100330

Researcher Affiliations

Pereira, Marcos F
  • Batatais Equine Veterinary Hospital, Rodovia Altino Arantes, 5500, Batatais, São Paulo 14300-000, Brazil.
Ribeiro, Gesiane
  • Faculty of Veterinary Medicine, Lusófona University of Humanities and Technology (FMV/ULHT), Campo Grande 376, Lisboa 1749-024, Portugal.
Gonzales, Alessandra
  • Batatais Equine Veterinary Hospital, Rodovia Altino Arantes, 5500, Batatais, São Paulo 14300-000, Brazil.
Arantes, Julia A
  • Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Rua Duque de Caxias Norte, 225, Jardim Elite, 13.635-900, Pirassununga, São Paulo, Brazil.
Dória, Renata G S
  • Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Rua Duque de Caxias Norte, 225, Jardim Elite, 13.635-900, Pirassununga, São Paulo, Brazil.

Conflict of Interest Statement

No competing interests have been declared.

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Citations

This article has been cited 1 times.
  1. Bungărdean D, Pall E, Daradics Z, Popescu M, Tripon MA, Lupșan AF, Crecan CM, Morar IA, Nicolescu A, Bora FD, Marcus I. In Vitro Effects of PRP, Ozonized PRP, Hyaluronic Acid, Paracetamol, and Polyacrylamide on Equine Synovial Fluid-Derived Mesenchymal Stem Cells. Life (Basel) 2025 Oct 4;15(10).
    doi: 10.3390/life15101558pubmed: 41157231google scholar: lookup
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