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JMIR dermatology2023; 6; e51070; doi: 10.2196/51070

Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study.

Abstract: Placental extract has been mostly used in skin care for cosmetic purposes. However, the use of various placental extracts has been limited due to the lack of established and effective application methods. Objective: In this study, we investigated the antiwrinkle effect of a cream formulation-LNC wrinkle eye cream (LNC-EC)-containing horse placental extract as the main ingredient. Methods: A total of 24 healthy women, aged 37-54 years, with wrinkle grades 1-3, were treated with LNC-EC for 2 weeks. The cream was applied on one-half of the participants' faces, and the results were compared with the untreated half of the face. Results: Visual inspection, using the wrinkle grade standard, showed that the area treated with LNC-EC had a significantly lower wrinkle grade than the untreated area when comparing before and after the application of LNC-EC. In addition, replica analysis showed a significant reduction in both the maximum wrinkle width and the number of wrinkles in the LNC-EC-treated area in comparison to the untreated area before and after the application. These results suggest that LNC-EC has an antiwrinkle effect on the corners of the eyes based on parameters like the maximum wrinkle width and the number of wrinkles. Conclusions: LNC-EC, with horse placental extract as its main ingredient, was shown to be effective in improving wrinkles at the eye corners, presumably due to a reduction in the maximum wrinkle width and the number of wrinkles. Interpretation of the results is limited because this study was conducted only in the intervention group. A randomized controlled trial with a placebo control group is necessary to verify the antiwrinkle effects of horse placental extract.
©Tsuyuko Watanabe, Kentarou Tahara, Eiichi Hirano. Originally published in JMIR Dermatology (http://derma.jmir.org), 15.11.2023.
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Publication Date: 2023-11-15 PubMed ID: 37966883PubMed Central: PMC10687675DOI: 10.2196/51070Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the anti-wrinkle effects of a skin cream with horse placental extract as a significant ingredient, using a single-blind comparative study involving 24 healthy women. The results indicate that this cream potentially has a beneficial effect on reducing wrinkles, particularly around the eye area, although the study acknowledges the need for further investigation via a randomized controlled trial.

Objective of the Study

  • The study is centered around discovering the potential anti-wrinkle effects of the LNC Wrinkle Eye Cream (LNC-EC), a cream primarily consisting of horse placental extract.

Methods

  • The participants of the study were 24 healthy women ranging from 37 to 54 years old, each with varied degrees of wrinkles (grades 1-3). The participants applied the LNC-EC to one half of their face for two weeks, while leaving the other half untreated.
  • The research used visual inspection following a wrinkle grade standard, and replica analysis for comparison between treated and untreated skin areas before and after applying the LNC-EC.

Results

  • The findings from the study suggest that application of LNC-EC led to a notable decrease in the wrinkle grade when compared to the untreated areas of the face.
  • Moreover, the replica analysis pointed to a considerable reduction in both the maximum wrinkle width and the total number of wrinkles in the LNC-EC-treated areas as compared to untreated areas.
  • Overall, the results imply that LNC-EC could have a positive anti-wrinkle impact, especially in the context of maximum wrinkle width and wrinkle count around the corners of the eyes.

Conclusions and Limitations

  • The LNC-EC’s main ingredient, horse placental extract, has shown potential to improve wrinkles around the corner of the eyes, likely due to minimising the maximum width of wrinkles and decreasing wrinkle count.
  • However, the study is limited in interpreting results because it was only conducted in the intervention group. Therefore, a randomized control trial with a placebo control group is necessary for properly verifying the anti-wrinkle effects of horse placental extract.

Cite This Article

APA
Watanabe T, Tahara K, Hirano E. (2023). Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study. JMIR Dermatol, 6, e51070. https://doi.org/10.2196/51070

Publication

JMIR dermatology
ISSN: 2562-0959
NlmUniqueID: 101770607
Country: Canada
Language: English
Volume: 6
Pages: e51070
PII: e51070

Researcher Affiliations

Watanabe, Tsuyuko
  • Medical Affairs Department, Japan Bio Products Co, Ltd, Tokyo, Japan.
Tahara, Kentarou
  • Medical Affairs Department, Japan Bio Products Co, Ltd, Tokyo, Japan.
Hirano, Eiichi
  • Medical Affairs Department, Japan Bio Products Co, Ltd, Tokyo, Japan.

Conflict of Interest Statement

Conflicts of Interest: All authors are employees of Japan Bio Products Co, Ltd.

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