Factors affecting measurement of basal adrenocorticotropic hormone in adult domestic equids: A scoping review.
Abstract: Measurement of basal adrenocorticotropic hormone (ACTH) concentration is the most commonly used diagnostic test for pituitary pars intermedia dysfunction (PPID). Although several pre-analytical and analytical factors have been reported to affect basal ACTH concentrations in equids, the extent to which these have been evaluated in the context of PPID diagnosis is unclear. The objectives of this scoping review were to identify and systematically chart current evidence about pre-analytical and analytical factors affecting basal ACTH concentrations in adult domestic equids. Systematic searches of electronic databases and conference proceedings were undertaken in June 2022, repeated in October 2022 and updated in August 2023. English language publications published prior to these dates were included. Screening and data extraction were undertaken individually by the authors, using predefined criteria and a modified scoping review data extraction template. After removal of duplicates, 903 publications were identified, of which 235 abstracts were screened for eligibility and 134 publications met inclusion criteria. Time of year, exercise, breed/type and transportation were the factors most frequently associated with significant increases in ACTH concentration (n=26, 16, 13 and 10 publications, respectively). Only 25 publications reported inclusion of PPID cases in the study population, therefore the relationship between many factors affecting basal ACTH concentration and diagnostic accuracy for PPID remains undefined. However, several factors were identified that could impact interpretation of basal ACTH results. Findings also highlight the need for detailed reporting of pre-analytical and analytical conditions in future research to facilitate translation of evidence to practice.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
Publication Date: 2024-02-08 PubMed ID: 38341024DOI: 10.1016/j.tvjl.2024.106071Google Scholar: Lookup
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Summary
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The research article presents a scoping review that inspects the various pre-analytical and analytical factors affecting the measurement of basal adrenocorticotropic hormone (ACTH) in adult domestic equids, which is essential in diagnosing pituitary pars intermedia dysfunction (PPID). The study reveals how certain variables such as time of year, exercise, breed/type, and transportation can significantly influence ACTH concentrations; however, further clarification is needed to understand their relationship with PPID diagnostic accuracy.
Objective of the Study
- The study aims to identify and systematically chart the evidence on factors impacting the measurement of basal ACTH in adult domestic equids, crucial information for diagnosing PPID.
Methodology
- Systematic searches of electronic databases and conference proceedings were undertaken in June 2022, repeated in October 2022, and updated in August 2023.
- Only English language publications published before these dates were included in the study.
- The authors individually screened and extracted data from the collected resources, using predefined criteria and a modified scoping review data extraction template.
Results
- 903 publications were initially identified. After removing duplicates, these were reduced to 235 abstracts screened for eligibility.
- Out of the screened abstracts, 134 met the inclusion criteria and were analyzed.
- The research identified that the time of year, exercise, breed/type, and transportation were factors most frequently associated with significant increases in ACTH concentration.
Limited Scope
- Only 25 out of the analyzed publications considered PPID cases in their study population. This limited scope leaves the relationship between many factors affecting basal ACTH concentration and their influence on diagnostic accuracy for PPID largely undefined.
Significance of Findings
- The study helps in identifying several factors that may interfere with the interpretation of basal ACTH results.
- It also emphasizes the need for detailed reporting of pre-analytical and analytical conditions in future research to aid the practical application of the evidence.
Cite This Article
APA
Ireland JL, Lester A, Banse HE.
(2024).
Factors affecting measurement of basal adrenocorticotropic hormone in adult domestic equids: A scoping review.
Vet J, 106071.
https://doi.org/10.1016/j.tvjl.2024.106071 Publication
Researcher Affiliations
- Department of Equine Clinical Science, Faculty of Health and Life Sciences, The University of Liverpool, Leahurst, CH64 7TE, Cheshire, UK. Electronic address: joirel@liverpool.ac.uk.
- Department of Equine Clinical Science, Faculty of Health and Life Sciences, The University of Liverpool, Leahurst, CH64 7TE, Cheshire, UK.
- School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
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