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Interrelationships between uterus and conceptus to maintain corpus luteum function in early pregnancy: sheep, cattle, pigs and horses.
Abstract: Processes associated with "Maternal Recognition of Pregnancy" are reviewed extensively from the ovine, bovine, porcine and equine species. Comparisons among these species indicate that CL maintenance is achieved primarily by a predominant antiluteolytic-anti PGF effect, and there is strong evidence for antiluteolytic-luteoprotective and luteotropic controls that complement this basic system. The nature of the chemical signals (steroids, prostaglandins and proteins) to regulate these processes among the species are described. Common to all of the species reviewed is a change in vascular dynamics to and from the uterus and ovary during early pregnancy. The dialogue between endometrial epithelium and trophectoderm of the developing conceptus is described. The consequence of these various physiological and biochemical responses of early pregnancy is maintenance of the CL to provide a sustained embryotrophic environment. Either in the absence of or death of a conceptus, an efficient and acute system is operational to terminate this progestational environment via regression of the CL through uterine production of PGF.
Publication Date: 1986-01-01 PubMed ID: 3533874DOI: 10.1093/ansci/62.2.25Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Review
Summary
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The research article discusses the interplay between the uterus and conceptus (early stage of embryo) in maintaining the function of the corpus luteum during early pregnancy. This is investigated in sheep, cattle, pigs, and horses, detailing the role of different chemical signals and the changes in vascular dynamics for supporting embryo development.
Comparison Across Different Species
- The article provides a comprehensive review of the process called “Maternal Recognition of Pregnancy” in different species such as sheep, cattle, pigs, and horses.
- Findings across these species suggest corpus luteum (CL) maintenance is primarily achieved through a dominant antiluteolytic-anti PGF effect, which stops the breakdown of the corpus luteum. Each species also exhibits antiluteolytic-luteoprotective and luteotropic controls that strengthen this system.
Role of Chemical Signals
- The researchers examine the chemical signals, specifically steroids, prostaglandins, and proteins, that regulate the processes associated with maintaining pregnancy in these species.
- These signals help in coordinating the interaction between the uterus and conceptus, securing the survival and growth of the embryo.
Changes in Vascular Dynamics
- The article reveals a commonality across all species studied—changes in vascular dynamics from the uterus to the ovary during early pregnancy.
- Such changes enable improved blood flow and nutrient supply, which are essential for the sustenance of the embryo at its early stages.
Endometrial Epithelium and Trophoblast Dialogue
- The article also delves into the interaction between the endometrial epithelium (inner lining of the uterus) and the trophoblast (outer layer of the conceptus).
- This interaction is crucial as the trophoblast facilitates interactions with the maternal uterus and lays the groundwork for the formation of the placenta.
Implications of Corpus Luteum Maintenance
- This intercommunication and regulation is what leads to the maintenance of the corpus luteum.
- Maintaining the corpus luteum is vital during early pregnancy as it produces the progesterone hormone, which creates favorable conditions for the growth of the embryo.
- In the absence or death of a conceptus, however, a rapid and efficient system kicks in to halt this environment by causing the regression of the corpus luteum through the uterus’s production of prostaglandin F2α (PGF).
Cite This Article
APA
Thatcher WW, Bazer FW, Sharp DC, Roberts RM.
(1986).
Interrelationships between uterus and conceptus to maintain corpus luteum function in early pregnancy: sheep, cattle, pigs and horses.
J Anim Sci, 62 Suppl 2, 25-46.
https://doi.org/10.1093/ansci/62.2.25 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cattle
- Corpus Luteum Maintenance
- Female
- Fetus / physiology
- Horses
- Pregnancy
- Pregnancy, Animal / physiology
- Prostaglandins F / physiology
- Sheep
- Swine
- Uterus / physiology
Citations
This article has been cited 7 times.- Fiorenza MF, Amaral CDS, da Anunciação ARA, Portela VVM, Marey MA, Miyamoto A, Antoniazzi AQ. Possible impact of neutrophils on immune responses during early pregnancy in ruminants. Anim Reprod 2021;18(3):e20210048.
- Lueders I, Niemuller C, Rich P, Gray C, Hermes R, Goeritz F, Hildebrandt TB. Gestating for 22 months: luteal development and pregnancy maintenance in elephants. Proc Biol Sci 2012 Sep 22;279(1743):3687-96.
- Stanford K, McAllister TA, Ayroud M, Bray TM, Yost GS. Effect of dietary melengestrol acetate on the incidence of acute interstitial pneumonia in feedlot heifers. Can J Vet Res 2006 Jul;70(3):218-25.
- Newton GR, Weise DW, Bowen JA, Woldesenbet S, Burghardt RC. Regulation of protein and prostaglandin secretion in polarized primary cultures of caprine uterine epithelial cells. In Vitro Cell Dev Biol Anim 1998 Jul-Aug;34(7):578-84.
- Nappi C, Gargiulo AR, Di Carlo C. The human luteal paracrine system: current concepts. J Endocrinol Invest 1994 Nov;17(10):825-36.
- Lafrance M, Goff AK, Guay P, Harvey D. Failure to maintain luteal function: a possible cause of early embryonic loss in a cow. Can J Vet Res 1989 Jul;53(3):279-84.
- Manta MW, da Silva EP, Feltrin SR, Prante AL, Aires KV, de Andrade LG, da Silva AP, Amaral CDS, Wink LM, Portela VM, Antoniazzi AQ. Human Chorionic Gonadotrophin (hCG) induces changes in IFN-pathway and Interferon-Stimulated Genes (ISGs) on the bovine endometrium at Day 18 of pregnancy. Anim Reprod 2024;21(1):e20230130.
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