Large animal ventilator-integrated volumetric capnography generates clinically acceptable values of physiologic dead space in anesthetized healthy adult horses.
Abstract: To evaluate the agreement between the Tafonius large animal ventilator-integrated volumetric capnography (vCap) software and the Respironics NICO noninvasive cardiac output monitor reference system. Methods: Data were collected from 56 healthy adult horses undergoing general anesthesia. Methods: Animals were placed under general anesthesia and connected to the Tafonius large animal ventilator circle system. A flow partitioning device with CO2 and flow sensors was utilized to couple the endotracheal tube to the NICO monitor. Tafonius CO2 and flow sensors are incorporated into the Y-piece of the breathing circuit. Arterial blood samples were collected to determine the partial pressure of arterial carbon dioxide (PaCO2) immediately before data collection. The PaCO2 was input into the Tafonius and NICO monitor, and dead space ventilation (%Vd), end-tidal CO2 partial pressure (ETco2), mixed-expired CO2 partial pressure (Peco2), and expired tidal volume (Vt) were calculated over a single breath. Multiple measurements were completed for each patient, with a total of 200 paired data points collected for analysis. Data were assessed for normality, and Bland-Altman analysis was performed. Bias and 95% limits of agreement were calculated. Results: The limits of agreement for %Vd of the ventilator-derived measurements fell within ± 10% of the NICO monitor reference method. Conclusions: Our results indicate that, when compared to the NICO monitor method, the Tafonius-integrated vCap software provides clinically acceptable values of Peco2, Vt, and %Vd in healthy adult horses.
Publication Date: 2023-10-23 PubMed ID: 37857347DOI: 10.2460/ajvr.23.05.0107Google Scholar: Lookup
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- Journal Article
Summary
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The study investigates the accuracy of a new software designed for horse ventilators. It compares the readings from the new software with those from a widely-accepted method. The results demonstrate that the new software provides reliable measurements in healthy adult horses.
Introduction and Objective
- The research aims to evaluate the Tafonius large animal ventilator-integrated volumetric capnography (vCap) software by comparing it with the widely used Respironics NICO noninvasive cardiac output monitor reference system.
- The goal is to assess the compatibility and accuracy of vital measurements like end-tidal CO2 partial pressure (ETco2), mixed-expired CO2 partial pressure (Peco2), and expired tidal volume (Vt) derived from the new software.
Methodology
- Data was collected from 56 healthy adult horses which were placed under general anaesthesia. Two separate CO2 and flow sensors were utilised – one integrated within the large animal ventilator system (Tafonius) and one coupled with the NICO monitor via a flow partitioning device attached to the endotracheal tube.
- Arterial blood samples were taken from the horses to determine the partial pressure of arterial carbon dioxide (PaCO2). These values were inputted into both the Tafonius software and the NICO monitor.
- Key ventilatory data such as dead space ventilation (%Vd), ETco2, Peco2, and Vt were calculated over a single breath. Multiple measurements were taken and assessed for normality using the Bland-Altman analysis. A total of 200 paired data points were collected for analysis.
Results
- The results suggested that the %Vd derived from the new ventilatory software was within +/- 10% agreement with the values obtained from the NICO monitor reference method.
- The limits of agreement showed that the new software’s biases were within clinically acceptable ranges.
Conclusion
- The study found that the new Tafonius-integrated vCap software can provide clinically acceptable values for key ventilatory parameters such as Peco2, Vt, and %Vd in healthy adult horses.
- When compared to the NICO monitor method, the Tafonius software seemed to perform reliably.
Cite This Article
APA
Frampton A, Floriano D, Simpson K, Hopster K.
(2023).
Large animal ventilator-integrated volumetric capnography generates clinically acceptable values of physiologic dead space in anesthetized healthy adult horses.
Am J Vet Res, 1-7.
https://doi.org/10.2460/ajvr.23.05.0107 Publication
Researcher Affiliations
- Department of Clinical Studies - New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
- Department of Clinical Studies - New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
- Department of Clinical Studies - New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
- Department of Clinical Studies - New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
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