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Journal of comparative pathology1953; 63(4); 286-293; doi: 10.1016/s0368-1742(53)80030-5

Levels of some chemical constituents in normal horse sera.

Abstract: THE chemical analyses reported in this paper arc the result of an investigation on the sera of thirty normal horses from a heavy draught horse stable in Glasgow. Determinations have been made of scrum proteins (albumin and total globulin), alkaline phosphatase, bilirubin, calcium, magnesium, inorganic phosphate and urea. Estimations of some of these constituents have already been carried out by a number of workers, but in the majority of cases the investigation has been confined to one or two constituents relevant to the problem being studied, and many of the data available are a by-product of other research. Westermarck (1942, 1952) has determined calcium, inorganic phosphate and total protein in the sera of normal Finnish horses. Bonsmann arid Weisner ;1951), Howe (1925), and Gilman (1952) have estimated total serum proteins. Values for the relative amounts of albumin and globulin have been obtained electrophoretically Svensson, 1946; Deutsch and Goodloe, 1945) and by sodium sulphate fractionation (Gilman, 1952). Although calcium and inorganic phosphate levels in equine sera have been extensively investigated (for references and figures sec Westermarck, 1952), there appears to be no published data on the serum alkaline phosphatase of the adult horse. The normal level of serum bilirubin in the horsc has been determined by Filches (1949). In view of the importance of measurements of the above con-stituents in clinical siork, their possible interrelation, and the changes associated with various pathological conditions, it was considered desirable to make the present survey on a group of normal adult animals.
Publication Date: 1953-10-01 PubMed ID: 13109034DOI: 10.1016/s0368-1742(53)80030-5Google Scholar: Lookup
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Summary

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This research paper discusses a chemical analysis conducted on the sera of thirty normal horses, with the aim to establish levels of various chemical constituents such as serum proteins, alkaline phosphatase, bilirubin, calcium, magnesium, inorganic phosphate, and urea. Previous studies had been limited, and the study therefore aimed to provide a comprehensive assessment, with findings contributing to a better understanding of clinical studies and the interrelation of these constituents.

Overview of the Research

  • The research was conducted on the sera of thirty normal horses derived from a heavy draught horse stable in Glasgow. The study is essentially a biochemical analysis aimed at understanding the levels of various chemical constituents typically present in horse serum.
  • The chemical constituents explored include serum proteins (albumin and total globulin), alkaline phosphatase, bilirubin, calcium, magnesium, inorganic phosphate, and urea. The aim was to determine the normal levels of these elements, providing baseline data that could be referenced in future animal studies and clinical work.

Previously Published Data Set

  • The research paper acknowledges the work of several other researchers who had conducted similar analyses on specific constituents of horse serum. However, the paper emphasizes that most of these investigations were limited in scope, focusing on one or two constituents and frequently, their data served as a byproduct of other research.
  • Previous research had provided data on calcium, inorganic phosphate, total serum proteins, and even relative amounts of albumin and globulin. However, information on the serum alkaline phosphatase levels in adult horses was lacking.

Significance of the Research

  • The present study aimed to provide a more comprehensive data set on the levels of chemical constituents found in horse serum. This information is not just beneficial in a veterinary context; it could also illuminate our understanding of certain human conditions.
  • The research underscores the relevance of the constituents investigated, pointing out their clinical importance, possible interrelations, and changes associated with various pathological conditions. Hence, the paper emphasizes the need for this extensive investigation on healthy adult horses to establish normative data.

Cite This Article

APA
JENNINGS FW, MULLIGAN W. (1953). Levels of some chemical constituents in normal horse sera. J Comp Pathol, 63(4), 286-293. https://doi.org/10.1016/s0368-1742(53)80030-5

Publication

ISSN: 0021-9975
NlmUniqueID: 0102444
Country: England
Language: English
Volume: 63
Issue: 4
Pages: 286-293

Researcher Affiliations

JENNINGS, F W
    MULLIGAN, W

      MeSH Terms

      • Animals
      • Blood
      • Horses

      Citations

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