Neonatal development of the diaphragm of the horse, Equus caballus.
Abstract: The diaphragm of neonatal horses is significantly different from the diaphragm of adult horses in terms of histochemical fiber type composition, myosin heavy chain isoform, and native myosin isoform composition. There is a significant increase in the percentage of type I fibers present in the diaphragm with increasing age from birth through about seven months postnatal age. A possible lack of postural tone in the hiatal region of the neonatal diaphragm is suggested to account for increased incidence of vomiting or aspiration pneumonia in younger horses. The isoform data lead to rejection of the hypothesis that the diaphragm of the horse should, as an ungulate, be relatively precocial in its rate of maturation relative to other non-ungulate mammals that have been studied.
Publication Date: 1994-03-01 PubMed ID: 8179212DOI: 10.1002/ar.1092380305Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research paper focuses on the development of the diaphragm in newborn horses and how it significantly varies from adult horses in multiple parameters. It also suggests a possible link between the lack of postural tone in the neonatal diaphragm and a higher incidence of vomiting or aspiration pneumonia in younger horses.
Overview of Research Focus
- The overall purpose of this study was to analyze the development of the neonatal horse diaphragm and compare it with adult horses in terms of histochemical fiber type composition, myosin heavy chain isoform, and native myosin isoform composition.
- Additionally, the researchers wanted to understand if these differences could account for an increased incidence of vomiting or aspiration pneumonia in younger horses.
Main Findings
- The researchers found that there was a notable increase in the percentage of type I fibers in the diaphragm from birth to about seven months of age.
- A key discovery was that the neonatal horse’s diaphragm may lack postural tone, specifically in the hiatal region. This finding is suggested to be a possible reason for a higher incidence of gastrointestinal issues such as vomiting or aspiration pneumonia in younger horses.
Rejection of Previous Hypothesis
- Interesting findings from the isoform data led the researchers to reject a pre-existing hypothesis. According to that hypothesis, being an ungulate (a group of mammals that use the tips of their toes, usually hoofed, to uphold all of their body weight while moving), the diaphragm of the horse was expected to show a relatively quicker rate of maturation as compared to other non-ungulate mammals.
- However, based on the research findings, this hypothesis was proven incorrect, indicating that the development and maturation of the horse’s diaphragm involve a unique sequence of alterations unlike other mammals previously studied.
Implications of the Research
- This research helps in better understanding the neonatal development of the horse diaphragm, its distinctiveness as compared to adults, and its link to certain health issues.
- These findings could be crucial for veterinary science, as it can help develop better clinical strategies for the management of neonatal horses, especially those who encounter higher incidences of vomiting or aspiration pneumonia.
Cite This Article
APA
Cobb MA, Schutt WA, Petrie JL, Hermanson JW.
(1994).
Neonatal development of the diaphragm of the horse, Equus caballus.
Anat Rec, 238(3), 311-316.
https://doi.org/10.1002/ar.1092380305 Publication
Researcher Affiliations
- Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401.
MeSH Terms
- Animals
- Animals, Newborn / growth & development
- Diaphragm / growth & development
- Diaphragm / metabolism
- Female
- Histocytochemistry
- Horses / growth & development
- Isoenzymes / metabolism
- Male
- Muscle Development
- Myosins / metabolism
Citations
This article has been cited 2 times.- Thometz NM, Dearolf JL, Dunkin RC, Noren DP, Holt MM, Sims OC, Cathey BC, Williams TM. Comparative physiology of vocal musculature in two odontocetes, the bottlenose dolphin (Tursiops truncatus) and the harbor porpoise (Phocoena phocoena). J Comp Physiol B 2018 Jan;188(1):177-193.
- Etnier SA, Dearolf JL, McLellan WA, Pabst DA. Postural role of lateral axial muscles in developing bottlenose dolphins (Tursiops truncatus). Proc Biol Sci 2004 May 7;271(1542):909-18.
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