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Home / Equine Research Bank / Vet Immunol Immunopathol / Passive immunisation, an old idea revisited: Basic principle...
Veterinary immunology and immunopathology2016; 174; 50-63; doi: 10.1016/j.vetimm.2016.04.007

Passive immunisation, an old idea revisited: Basic principles and application to modern animal production systems.

Abstract: Immunisation by administration of antibodies (immunoglobulins) has been known for more than one hundred years as a very efficient means of obtaining immediate, short-lived protection against infection and/or against the disease-causing effects of toxins from microbial pathogens and from other sources. Thus, due to its rapid action, passive immunisation is often used to treat disease caused by infection and/or toxin exposure. However immunoglobulins may also be administered prior to exposure to infection and/or toxin, although they will not provide long-lasting protection as is seen with active immunisation (vaccination) in which an immunological memory is established by controlled exposure of the host to the pathogen in question. With multi-factorial infectious diseases in production animals, especially those that have proven hard to control by vaccination, the potential of passive immunisation remains big. This review highlights a number of examples on the use of passive immunisation for the control of infectious disease in the modern production of a range of animals, including pigs, cattle, sheep, goat, poultry and fish. Special emphasis is given on the enablement of passive immunisation strategies in these production systems through low cost and ease of use as well as on the sources, composition and purity of immunoglobulin preparations used and their benefits as compared to current measures, including vaccination (also comprising maternal vaccination), antibiotics and feed additives such as spray-dried plasma. It is concluded that provided highly efficient, relatively low-price immunoglobulin products are available, passive immunisation has a clear role in the modern animal production sector as a means of controlling infectious diseases, importantly with a very low risk of causing development of bacterial resistance, thus constituting a real and widely applicable alternative to antibiotics.
Copyright © 2016 Elsevier B.V. All rights reserved.
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Publication Date: 2016-04-26 PubMed ID: 27185263PubMed Central: PMC7127230DOI: 10.1016/j.vetimm.2016.04.007Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper revisits the concept of passive immunisation, where antibodies are administered to provide short-lived, immediate protection against infections and toxins. The paper discusses how passive immunisation is applicable in the animal production industry, providing an alternative method to control infectious diseases in animals.

Basic Principles of Passive Immunisation

  • This paper discusses passive immunisation, a method providing immediate protection against diseases and infections by administering antibodies, also known as immunoglobulins.
  • This form of immunisation does not provide long-term protection as it lacks the immunological memory triggered by active immunisation via vaccines.
  • However, the rapid-action capability of passive immunisation proves valuable in controlling diseases, especially those hard to contain using vaccines.

Application to Modern Animal Production Systems

  • The paper examines the potential of passive immunisation in the context of modern animal production, ranging from pigs and cattle to poultry and fish.
  • An emphasis is placed on passive immunisation strategies that offer low-cost and ease of use in these production systems.
  • The sources, composition, and purity of the administered immunoglobulin preparations are also examined alongside their benefits compared to current measures like vaccinations, antibiotics, and feed additives such as spray-dried plasma.

Passive Immunisation as a Means of Controlling Infectious Diseases

  • Concluding, the paper highlights passive immunisation’s potential as a means of disease control in the modern animal production sector with minimal risk of generating bacterial resistance.
  • Thus, passive immunisation may serve as a real, practical alternative to antibiotics usage in the industry, provided that effective, reasonably priced immunoglobulin products are available.

Cite This Article

APA
Hedegaard CJ, Heegaard PM. (2016). Passive immunisation, an old idea revisited: Basic principles and application to modern animal production systems. Vet Immunol Immunopathol, 174, 50-63. https://doi.org/10.1016/j.vetimm.2016.04.007

Publication

Veterinary immunology and immunopathology
ISSN: 1873-2534
NlmUniqueID: 8002006
Country: Netherlands
Language: English
Volume: 174
Pages: 50-63
PII: S0165-2427(16)30064-2

Researcher Affiliations

Hedegaard, Chris J
  • National Veterinary Institute, Technical University of Denmark, Section for Immunology and Vaccinology, The innate immunology Group, Denmark. Electronic address: cjhe@vet.dtu.dk.
Heegaard, Peter M H
  • National Veterinary Institute, Technical University of Denmark, Section for Immunology and Vaccinology, The innate immunology Group, Denmark.

MeSH Terms

  • Animal Husbandry / methods
  • Animal Husbandry / trends
  • Animals
  • Animals, Newborn
  • Cattle
  • Female
  • Fishes
  • Goats
  • Horses
  • Humans
  • Immunity, Innate
  • Immunity, Maternally-Acquired
  • Immunization, Passive / methods
  • Immunization, Passive / trends
  • Immunization, Passive / veterinary
  • Immunoglobulins / administration & dosage
  • Immunoglobulins / isolation & purification
  • Male
  • Poultry
  • Pregnancy
  • Sheep
  • Sus scrofa

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