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Home / Equine Research Bank / Clin Transl Allergy / Pollen Allergies in Humans and their Dogs, Cats and Horses: ...
Clinical and translational allergy2015; 5; 15; doi: 10.1186/s13601-015-0059-6

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities.

Abstract: Both humans and their most important domestic animals harbor IgE and a similar IgE receptor repertoire and expression pattern. The same cell types are also involved in the triggering or regulation of allergies, such as mast cells, eosinophils or T-regulatory cells. Translational clinical studies in domestic animals could therefore help cure animal allergies and at the same time gather knowledge relevant to human patients. Dogs, cats and horses may spontaneously and to different extents develop immediate type symptoms to pollen allergens. The skin, nasal and bronchial reactions, as well as chronic skin lesions due to pollen are in principle comparable to human patients. Pollen of various species most often causes allergic rhinitis in human patients, whereas in dogs it elicits predominantly eczematous lesions (canine atopic dermatitis), in horses recurrent airway obstruction or hives as well as pruritic dermatitis, and in cats bronchial asthma and so-called cutaneous reactive patterns (eosinophilic granuloma complex, head and neck pruritus, symmetric self-induced alopecia). In human allergy-specific IgE detection, skin tests or other allergen provocation tests should be completed. In contrast, in animals IgE and dermal tests are regarded as equally important and may even replace each other. However, for practical and economic reasons intradermal tests are most commonly performed in a specialized practice. As in humans, in dogs, cats and horses allergen immunotherapy leads to significant improvement of the clinical symptoms. The collected evidence suggests that canines, felines and equines, with their spontaneous allergies, are attractive model patients for translational studies.
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Publication Date: 2015-04-07 PubMed ID: 25852853PubMed Central: PMC4387677DOI: 10.1186/s13601-015-0059-6Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the similarities and differences in pollen allergies among humans, dogs, cats, and horses. It suggests that these animals could be potential models for studying allergies and developing treatments in humans.

Similar Allergic Reactions

Humans and their domestic animals exhibit similar allergic reactions as they both have Immunoglobulin E (IgE) and similar IgE receptor repertoire and expression pattern. This implies that when exposed to allergens like pollen, the same cell types are involved in allergic responses. These include mast cells, eosinophils or T-regulatory cells which are largely responsible for triggering or regulating allergies.

Varying Symptoms

While there are similarities, there are also differences in how these allergies manifest across species. Pollen allergies in dogs typically cause eczematous lesions, which are chronic skin conditions characterized by inflammation and itching. Horses react to pollen allergies through recurrent airway obstruction or hives as well as pruritic dermatitis, a type of skin inflammation causing intense itching. Cats often suffer from bronchial asthma and a variety of skin reactions.

Diagnosis and Treatment

The article also touches on the differences in diagnosing allergies. In humans, allergy-specific IgE detection, skin tests or other allergen provocation tests are often used. However, in animals, IgE and dermal tests are viewed as equally important. For practical and economic reasons, intradermal tests are most commonly administered in a specialized veterinary practice. Despite the differences, allergen immunotherapy is found to significantly improve clinical symptoms in all subjects – humans, dogs, cats, and horses.

Possible Study Models

In conclusion, the researchers suggest that dogs, cats, and horses, with their spontaneous allergies, could serve as attractive model subjects in translational studies. They note that clinical studies in these domestic animals could not only help find cures for animal allergies but also gather valuable knowledge relevent for human patients.

Cite This Article

APA
Jensen-Jarolim E, Einhorn L, Herrmann I, Thalhammer JG, Panakova L. (2015). Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities. Clin Transl Allergy, 5, 15. https://doi.org/10.1186/s13601-015-0059-6

Publication

Clinical and translational allergy
ISSN: 2045-7022
NlmUniqueID: 101576043
Country: England
Language: English
Volume: 5
Pages: 15

Researcher Affiliations

Jensen-Jarolim, Erika
  • Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, c/o Institute of Pathophysiology and Allergy Research, Währinger G. 18-20, Vienna, 1090 Austria.
Einhorn, Lukas
  • Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, c/o Institute of Pathophysiology and Allergy Research, Währinger G. 18-20, Vienna, 1090 Austria.
Herrmann, Ina
  • Dermatology Unit, Clinics of Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Thalhammer, Johann G
  • Dermatology Unit, Clinics of Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Panakova, Lucia
  • Dermatology Unit, Clinics of Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.

Grant Funding

  • F 4606 / Austrian Science Fund FWF

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Citations

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