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Home / Equine Research Bank / Vet Microbiol / Pythium insidiosum: an overview.
Veterinary microbiology2010; 146(1-2); 1-16; doi: 10.1016/j.vetmic.2010.07.019

Pythium insidiosum: an overview.

Abstract: Pythium insidiosum is an oomycete pathogenic in mammals. The infection occurs mainly in tropical and subtropical areas, particularly in horses, dogs and humans. Infection is acquired through small wounds via contact with water that contains motile zoospores or other propagules (zoospores or hyphae). The disease, though described as emerging has in fact already been described since 1884. Depending on the site of entry, infection can lead to different forms of pythiosis i.e. a cutaneous, vascular, ocular, gastrointestinal and a systemic form, which is rarely seen. The infection is not contagious; no animal-animal or animal-human transmission has been reported so far. Therapy includes radical surgery, antifungal drugs, immunotherapy or a combination of these therapies. The prevention to contract the disease in endemic areas is difficult. Avoiding stagnant waters could be of help, although the presence of P. insidiosum on grass and soil in enzootic areas renders this practice useless.
Copyright © 2010 Elsevier B.V. All rights reserved.
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Publication Date: 2010-07-24 PubMed ID: 20800978DOI: 10.1016/j.vetmic.2010.07.019Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about Pythium insidiosum, a pathogen in mammals that causes the disease pythiosis. It provides an overview of the disease, its transmission methods, forms, treatments, and difficulty in prevention.

Overview of Pythium insidiosum

  • The article begins with an introduction to Pythium insidiosum, an oomycete that is pathogenic in mammals. Oomycetes are a group of fungus-like organisms, and the specific one discussed in the study, Pythium insidiosum, is associated with various forms of disease in mammals.
  • This pathogen is primarily found in tropical and subtropical regions and is known to infect horses, dogs, and humans. It has been recognized since 1884, despite being referred to as an ’emerging’ disease.

Transmission & Different Forms

  • The study highlights that infection with Pythium insidiosum typically occurs via small wounds that come into contact with water containing the pathogen’s motile zoospores or other propagules (zoospores or hyphae).
  • Depending on the site of entry, the infection can take on different forms – cutaneous, vascular, ocular, gastrointestinal, and systemic. The least common is the systemic form.
  • Crucially, it is noted that the disease is not contagious. There is no evidence of transmission from animal to animal or from animal to human.

Treatment and Prevention

  • The article then goes on to discuss the treatment options for Pythium insidiosum infection. These include options such as radical surgery, antifungal drugs, immunotherapy, or a combination of these therapies.
  • Prevention of the disease, especially in areas where it is endemic, presents challenges. While avoiding contact with stagnant water might reduce the risk of infection, this measure is rendered ineffective by the fact that the pathogen has been found on grass and soil in these regions.

Cite This Article

APA
Gaastra W, Lipman LJ, De Cock AW, Exel TK, Pegge RB, Scheurwater J, Vilela R, Mendoza L. (2010). Pythium insidiosum: an overview. Vet Microbiol, 146(1-2), 1-16. https://doi.org/10.1016/j.vetmic.2010.07.019

Publication

Veterinary microbiology
ISSN: 1873-2542
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 146
Issue: 1-2
Pages: 1-16

Researcher Affiliations

Gaastra, Wim
  • Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Lipman, Len J A
    De Cock, Arthur W A M
      Exel, Tim K
        Pegge, Raymond B G
          Scheurwater, Josje
            Vilela, Raquel
              Mendoza, Leonel

                MeSH Terms

                • Animals
                • Animals, Zoo / microbiology
                • Antifungal Agents / therapeutic use
                • Cats / microbiology
                • Cattle
                • Cattle Diseases / microbiology
                • Dog Diseases / microbiology
                • Dogs / microbiology
                • Horse Diseases / microbiology
                • Horses / microbiology
                • Humans
                • Phylogeny
                • Pythiosis / drug therapy
                • Pythiosis / etiology
                • Pythiosis / microbiology
                • Pythiosis / pathology
                • Pythiosis / veterinary
                • Pythium / drug effects
                • Pythium / genetics
                • Rabbits
                • Sheep / microbiology
                • Sheep Diseases / microbiology

                Citations

                This article has been cited 124 times.
                1. Jaturapaktrarak C, Sae-Chew P, Rujirawat T, Reamtong O, Krajaejun T. Immunoproteomic approach identifies a putative virulence chaperone DnaK protein as a candidate diagnostic marker and therapeutic target for Pythium insidiosum infection. Heliyon 2025 Feb 28;11(4):e42487.
                  doi: 10.1016/j.heliyon.2025.e42487pubmed: 41477492google scholar: lookup
                2. Liu X, Diao Q, Li M, Yang Y, Liang J, Cui Z, Zhang H, He H, Huang J, Ren H, Zhou F, Shan T, Liao X, Sun J, Zhang K. Worldwide distribution of human pythosis and biological characteristics of a Pythium insidiosum strain susceptible to antibiotics from China: a dual-scale study. Front Med (Lausanne) 2025;12:1629018.
                  doi: 10.3389/fmed.2025.1629018pubmed: 41446846google scholar: lookup
                3. de Oliveira RC, Lopes KHDS, Gonçalves MRS, de Carvalho MG, da Silva YSAD, de Vasconcelos LG, Júnior PTS, Violante IMP, Ribeiro TAN. Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots. Chem Biodivers 2026 Feb;23(2):e02503.
                  doi: 10.1002/cbdv.202502503pubmed: 41417493google scholar: lookup
                4. Brodkin J, Frederick SW, Rick M, Chapman PS. Vitamin D-Mediated Hypercalcemia in a Dog With Putative Cutaneous Pythiosis. Clin Case Rep 2025 Dec;13(12):e71594.
                  doi: 10.1002/ccr3.71594pubmed: 41356631google scholar: lookup
                5. Vasconcelos AB, França DA, Prado ACD, Yamauchi DH, Silva ACAD, Barros IO, Valença SRFA, Lucheis SB, Bosco SMG. Molecular Detection of Pythium insidiosum in Cutaneous Lesions of Horses from Northeastern Brazil. Animals (Basel) 2025 Sep 30;15(19).
                  doi: 10.3390/ani15192863pubmed: 41096457google scholar: lookup
                6. Yang J, Bhassu S, Ali G, Govindasamy T, Aziz MA, Rajamanikam A. Ecological Health and Freshwater Pathogen Using eDNA Metabarcoding: A Preliminary Assessment for Environmental Surveillance Development in Malaysia. Microorganisms 2025 Sep 4;13(9).
                  doi: 10.3390/microorganisms13092055pubmed: 41011388google scholar: lookup
                7. Laevens GCS, Dolson WC, Drapeau MM, Telhig S, Ruffell SE, Rose DM, Glick BR, Stegelmeier AA. The Good, the Bad, and the Fungus: Insights into the Relationship Between Plants, Fungi, and Oomycetes in Hydroponics. Biology (Basel) 2024 Dec 4;13(12).
                  doi: 10.3390/biology13121014pubmed: 39765681google scholar: lookup
                8. Tongchai P, Burassakarn A, Langsiri N, Worasilchai N, Chindamporn A. Development of lateral flow immunochromatographic assay with Anti-Pythium insidiosum antibodies for point-of-care testing of vascular pythiosis. Sci Rep 2025 Jan 4;15(1):781.
                  doi: 10.1038/s41598-024-84833-ypubmed: 39755905google scholar: lookup
                9. Li M, Zhu D, Diao Q, Liu X, Bi X, Dong J, Sun J, Xi Y, Zhang K. Clinical Features, Microbiological Characteristics, and Drug Sensitivity Analysis of Rare Human Spinal Pythiosis Strain. J Fungi (Basel) 2024 Nov 22;10(12).
                  doi: 10.3390/jof10120812pubmed: 39728308google scholar: lookup
                10. Fernandes CM, Prestes AS, Ianiski LB, Maciel AF, Noro BG, da Silva FD, Vizzotto BS, Botton SA, Schumacher RF, Pereira DIB, Barbosa NV. Anti-Pythium insidiosum activity of three novel triazole compounds: synthesis, pharmacokinetic and toxicological parameters. Braz J Microbiol 2025 Mar;56(1):331-340.
                  doi: 10.1007/s42770-024-01572-ypubmed: 39666162google scholar: lookup
                11. Vilela R, Grady SC, Vilela PR, Mendoza L. Geographical distribution of human pythiosis in the USA. Microbiol Spectr 2025 Jan 7;13(1):e0210324.
                  doi: 10.1128/spectrum.02103-24pubmed: 39641546google scholar: lookup
                12. Sridapan T, Jaturapaktrarak C, Rujirawat T, Jiaranaikulwanich A, Yurayart C, Krajaejun T. A colorimetric loop-mediated isothermal amplification assay (c-LAMP) for rapid detection of Pythium insidiosum. Heliyon 2024 Nov 30;10(22):e40478.
                  doi: 10.1016/j.heliyon.2024.e40478pubmed: 39641085google scholar: lookup
                13. Yurayart N, Jittorntam P, Kumsang Y, Rujirawat T, Jiaranaikulwanich A, Krajaejun T. Enhanced detection of Pythium insidiosum via lipid profiling with matrix-assisted laser desorption ionization time of flight mass spectrometry. IMA Fungus 2024 Nov 1;15(1):32.
                  doi: 10.1186/s43008-024-00163-8pubmed: 39482776google scholar: lookup
                14. Kundu R, Bansal Y, Singla N. The Zoonotic Potential of Fungal Pathogens: Another Dimension of the One Health Approach. Diagnostics (Basel) 2024 Sep 15;14(18).
                  doi: 10.3390/diagnostics14182050pubmed: 39335729google scholar: lookup
                15. Hu L, Huang X, Yee NH, Meng H, Jiang L, Liang L, Chen X. Pythium insidiosum: an emerging pathogen that is easily misdiagnosed and given treatment as a fungus. Front Cell Infect Microbiol 2024;14:1430032.
                  doi: 10.3389/fcimb.2024.1430032pubmed: 39268488google scholar: lookup
                16. Zhang X, Qi X, Lu X, Gao H. Modified tectonic corneoscleral graft technique for treating devastating corneoscleral infections. BMC Ophthalmol 2024 Sep 11;24(1):402.
                  doi: 10.1186/s12886-024-03669-2pubmed: 39261792google scholar: lookup
                17. Bhunjun CS, Chen YJ, Phukhamsakda C, Boekhout T, Groenewald JZ, McKenzie EHC, Francisco EC, Frisvad JC, Groenewald M, Hurdeal VG, Luangsa-Ard J, Perrone G, Visagie CM, Bai FY, Błaszkowski J, Braun U, de Souza FA, de Queiroz MB, Dutta AK, Gonkhom D, Goto BT, Guarnaccia V, Hagen F, Houbraken J, Lachance MA, Li JJ, Luo KY, Magurno F, Mongkolsamrit S, Robert V, Roy N, Tibpromma S, Wanasinghe DN, Wang DQ, Wei DP, Zhao CL, Aiphuk W, Ajayi-Oyetunde O, Arantes TD, Araujo JC, Begerow D, Bakhshi M, Barbosa RN, Behrens FH, Bensch K, Bezerra JDP, Bilański P, Bradley CA, Bubner B, Burgess TI, Buyck B, Čadež N, Cai L, Calaça FJS, Campbell LJ, Chaverri P, Chen YY, Chethana KWT, Coetzee B, Costa MM, Chen Q, Custódio FA, Dai YC, Damm U, Santiago ALCMA, De Miccolis Angelini RM, Dijksterhuis J, Dissanayake AJ, Doilom M, Dong W, Álvarez-Duarte E, Fischer M, Gajanayake AJ, Gené J, Gomdola D, Gomes AAM, Hausner G, He MQ, Hou L, Iturrieta-González I, Jami F, Jankowiak R, Jayawardena RS, Kandemir H, Kiss L, Kobmoo N, Kowalski T, Landi L, Lin CG, Liu JK, Liu XB, Loizides M, Luangharn T, Maharachchikumbura SSN, Mkhwanazi GJM, Manawasinghe IS, Marin-Felix Y, McTaggart AR, Moreau PA, Morozova OV, Mostert L, Osiewacz HD, Pem D, Phookamsak R, Pollastro S, Pordel A, Poyntner C, Phillips AJL, Phonemany M, Promputtha I, Rathnayaka AR, Rodrigues AM, Romanazzi G, Rothmann L, Salgado-Salazar C, Sandoval-Denis M, Saupe SJ, Scholler M, Scott P, Shivas RG, Silar P, Silva-Filho AGS, Souza-Motta CM, Spies CFJ, Stchigel AM, Sterflinger K, Summerbell RC, Svetasheva TY, Takamatsu S, Theelen B, Theodoro RC, Thines M, Thongklang N, Torres R, Turchetti B, van den Brule T, Wang XW, Wartchow F, Welti S, Wijesinghe SN, Wu F, Xu R, Yang ZL, Yilmaz N, Yurkov A, Zhao L, Zhao RL, Zhou N, Hyde KD, Crous PW. What are the 100 most cited fungal genera?. Stud Mycol 2024 Jul;108:1-411.
                  doi: 10.3114/sim.2024.108.01pubmed: 39100921google scholar: lookup
                18. Acharya M, Singh A, Nidhi V, Tiwari A, Gandhi A, Chaudhari I. Outcomes of keratoplasty in a cohort of Pythium insidiosum keratitis cases at a tertiary eye care center in India. Indian J Ophthalmol 2024 Aug 1;72(8):1124-1129.
                  doi: 10.4103/IJO.IJO_3108_23pubmed: 39078955google scholar: lookup
                19. Pereira DIB, Botton SA, Ianiski LB, Braga CQ, Maciel AF, Melo LG, Zambrano CG, Bruhn FRP, Santurio JM. Equidae pythiosis in Brazil and the world: a systematic review of the last 63 years (1960-2023). Braz J Microbiol 2024 Sep;55(3):2969-2981.
                  doi: 10.1007/s42770-024-01435-6pubmed: 38967702google scholar: lookup
                20. Joseph R, Darrisaw C, Lloyd A, Hoel D, Keyhani NO. Isolation of a Novel Pythium Species, P. thermoculicivorax, and Trichoderma sp. from Natural Enzootic Mosquito Larval Infections. J Fungi (Basel) 2024 Mar 5;10(3).
                  doi: 10.3390/jof10030199pubmed: 38535208google scholar: lookup
                21. Roy M, Borden J, Kasper DJ. Subcutaneous pythiosis in human treated successfully with antimicrobial treatment, debridement and immunotherapy. BMJ Case Rep 2024 Mar 18;17(3).
                  doi: 10.1136/bcr-2023-258587pubmed: 38499351google scholar: lookup
                22. Gurnani B, Natarajan R, Mohan M, Kaur K. Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis. Clin Ophthalmol 2024;18:765-776.
                  doi: 10.2147/OPTH.S450665pubmed: 38495678google scholar: lookup
                23. Leksuwankun S, Plongla R, Eamrurksiri N, Torvorapanit P, Phongkhun K, Langsiri N, Meejun T, Srisurapanont K, Thanakitcharu J, Lerttiendamrong B, Thongkam A, Manothummetha K, Chuleerarux N, Moonla C, Worasilchai N, Chindamporn A, Permpalung N, Nematollahi S. Needs assessment of a pythiosis continuing professional development program. PLoS Negl Trop Dis 2024 Feb;18(2):e0012004.
                  doi: 10.1371/journal.pntd.0012004pubmed: 38408109google scholar: lookup
                24. Kittichotirat W, Patumcharoenpol P, Rujirawat T, Tangphatsornruang S, Yurayart C, Krajaejun T. Pins Gene Table v2.0: An Online Genome Database of 37 Pythium insidiosum Strains for Gene Content Exploration and Phylogenomic Analysis. J Fungi (Basel) 2024 Jan 29;10(2).
                  doi: 10.3390/jof10020112pubmed: 38392784google scholar: lookup
                25. Medhasi S, Sriwarom A, Permpalung N, Torvorapanit P, Plongla R, Chindamporn A, Worasilchai N. Ex vivo observation of Pythium insidiosum-antigen treated neutrophils on three Pythium insidiosum strains isolated from vascular pythiosis patients. Hum Vaccin Immunother 2024 Dec 31;20(1):2304372.
                  doi: 10.1080/21645515.2024.2304372pubmed: 38314761google scholar: lookup
                26. Barrs VR, Beczkowski PM, Talbot JJ, Hobi S, Teoh SN, Hernandez Muguiro D, Shubitz LF, Sandy J. Invasive Fungal Infections and Oomycoses in Cats: 1. Diagnostic approach. J Feline Med Surg 2024 Jan;26(1):1098612X231219696.
                  doi: 10.1177/1098612X231219696pubmed: 38189288google scholar: lookup
                27. Braga CQ, Zambrano CG, Dos Santos Bermann C, Milech A, Ianiski LB, Soares MP, Pötter L, de Avila Botton S, Pereira DIB. In vitro and ex vivo anti-Pythium insidiosum potential of ozonated sunflower oil. Braz J Microbiol 2024 Mar;55(1):867-873.
                  doi: 10.1007/s42770-023-01173-1pubmed: 37999913google scholar: lookup
                28. Krajaejun T, Patumcharoenpol P, Rujirawat T, Kittichotirat W, Tangphatsornruang S. MGI short-read genome assemblies of Pythium insidiosum (reclassified as Pythium periculosum) strains Pi057C3 and Pi050C3. BMC Res Notes 2023 Nov 6;16(1):316.
                  doi: 10.1186/s13104-023-06587-6pubmed: 37932861google scholar: lookup
                29. Veldhuis Kroeze EJB, van Elk CE, van de Bildt MWG, van Run PRWA, Foster G, Abou-Chakra N, Hare RK, Kuiken T. Infection with Pythium flevoense in a harbour porpoise (Phocoena phocoena) as a novel cause of dermatitis in marine mammals. Vet Res 2023 Nov 2;54(1):102.
                  doi: 10.1186/s13567-023-01226-1pubmed: 37919808google scholar: lookup
                30. Billings P, Walton S, Shmalberg J, Santoro D. The Use of Mefenoxam to Treat Cutaneous and Gastrointestinal Pythiosis in Dogs: A Retrospective Study. Microorganisms 2023 Jun 30;11(7).
                  doi: 10.3390/microorganisms11071726pubmed: 37512898google scholar: lookup
                31. Peano A, Min ARM, Fondati A, Romano E, Brachelente C, Porcellato I, Amore A, Pasquetti M. Cutaneous Pythiosis in 2 Dogs, Italy. Emerg Infect Dis 2023 Jul;29(7):1447-1450.
                  doi: 10.3201/eid2907.230320pubmed: 37347828google scholar: lookup
                32. Bowman J, Gull T, Ulmanis EG, Ogunbadewa AJ, Shen Z, Johnson GJ, Odemuyiwa SO. Metagenomic identification of a novel oomycete cultured from a pyogranulomatous mass on the tail of a domestic cat. J Vet Diagn Invest 2023 Sep;35(5):507-513.
                  doi: 10.1177/10406387231180310pubmed: 37317863google scholar: lookup
                33. Kittichotirat W, Rujirawat T, Patumcharoenpol P, Krajaejun T. Comparative Genomic Analysis Reveals Gene Content Diversity, Phylogenomic Contour, Putative Virulence Determinants, and Potential Diagnostic Markers within Pythium insidiosum Traits. J Fungi (Basel) 2023 Jan 27;9(2).
                  doi: 10.3390/jof9020169pubmed: 36836284google scholar: lookup
                34. Sriwarom A, Chiewchengchol D, Saithong S, Worasilchai N, Chindamporn A. Neutrophil extracellular traps and phagocytosis in Pythium insidiosum. PLoS One 2023;18(1):e0280565.
                  doi: 10.1371/journal.pone.0280565pubmed: 36693041google scholar: lookup
                35. Sridapan T, Krajaejun T. Nucleic Acid-Based Detection of Pythium insidiosum: A Systematic Review. J Fungi (Basel) 2022 Dec 23;9(1).
                  doi: 10.3390/jof9010027pubmed: 36675848google scholar: lookup
                36. Yolanda H, Lohnoo T, Rujirawat T, Yingyong W, Kumsang Y, Sae-Chew P, Payattikul P, Krajaejun T. Selection of an Appropriate In Vitro Susceptibility Test for Assessing Anti-Pythium insidiosum Activity of Potassium Iodide, Triamcinolone Acetonide, Dimethyl Sulfoxide, and Ethanol. J Fungi (Basel) 2022 Oct 24;8(11).
                  doi: 10.3390/jof8111116pubmed: 36354883google scholar: lookup
                37. Zhang H, Zhou F, Huang J, Liu X, Xu H, Liang J, Wang J, Chen J, Liu L, Li Y, Hu X, Chen X, Liu C, Zhang K. Severe skin and subcutaneous pythiosis in China: Metagenomic identification and characterization of Pythium insidiosum. Front Microbiol 2022;13:1002460.
                  doi: 10.3389/fmicb.2022.1002460pubmed: 36246283google scholar: lookup
                38. Sukanan P, Suparp B, Yongsiri S, Chansiripornchai P, Kesdangsakonwut S. Successful management of colonic pythiosis in two dogs in Thailand using antifungal therapy. Vet Med Sci 2022 Nov;8(6):2283-2291.
                  doi: 10.1002/vms3.955pubmed: 36173734google scholar: lookup
                39. Elshafie NO, Hanlon J, Malkawi M, Sayedahmed EE, Guptill LF, Jones-Hall YL, Santos AP. Nested PCR Detection of Pythium sp. from Formalin-Fixed, Paraffin-Embedded Canine Tissue Sections. Vet Sci 2022 Aug 19;9(8).
                  doi: 10.3390/vetsci9080444pubmed: 36006359google scholar: lookup
                40. Gurnani B, Kaur K, Agarwal S, Lalgudi VG, Shekhawat NS, Venugopal A, Tripathy K, Srinivasan B, Iyer G, Gubert J. Pythium insidiosum Keratitis: Past, Present, and Future. Ophthalmol Ther 2022 Oct;11(5):1629-1653.
                  doi: 10.1007/s40123-022-00542-7pubmed: 35788551google scholar: lookup
                41. Krajaejun T, Rujirawat T, Lohnoo T, Yingyong W, Sae-Chew P, Reamtong O, Kittichotirat W, Patumcharoenpol P. Secretome Profiling by Proteogenomic Analysis Shows Species-Specific, Temperature-Dependent, and Putative Virulence Proteins of Pythium insidiosum. J Fungi (Basel) 2022 May 20;8(5).
                  doi: 10.3390/jof8050527pubmed: 35628782google scholar: lookup
                42. Medhasi S, Chindamporn A, Worasilchai N. A Review: Antimicrobial Therapy for Human Pythiosis. Antibiotics (Basel) 2022 Mar 26;11(4).
                  doi: 10.3390/antibiotics11040450pubmed: 35453202google scholar: lookup
                43. Gurnani B, Kaur K, Venugopal A, Srinivasan B, Bagga B, Iyer G, Christy J, Prajna L, Vanathi M, Garg P, Narayana S, Agarwal S, Sahu S. Pythium insidiosum keratitis - A review. Indian J Ophthalmol 2022 Apr;70(4):1107-1120.
                  doi: 10.4103/ijo.IJO_1534_21pubmed: 35325996google scholar: lookup
                44. de Souza Silveira J, Brasil CL, Braga CQ, da Silva Moreira Â, Franz HC, Zamboni R, Sallis ES, Albano AP, Zambrano CG, Araujo LC, de Bona da Silva C, Pötter L, de Avila Botton S, Pereira DIB. Melaleuca alternifolia formulations in the treatment of experimental pythiosis. Braz J Microbiol 2022 Jun;53(2):1011-1017.
                  doi: 10.1007/s42770-022-00720-6pubmed: 35239152google scholar: lookup
                45. Yolanda H, Krajaejun T. Global Distribution and Clinical Features of Pythiosis in Humans and Animals. J Fungi (Basel) 2022 Feb 11;8(2).
                  doi: 10.3390/jof8020182pubmed: 35205934google scholar: lookup
                46. Denardi LB, Weiblen C, Ianiski LB, Stibbe PC, Pinto SC, Santurio JM. Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides. Braz J Microbiol 2022 Mar;53(1):509-512.
                  doi: 10.1007/s42770-022-00678-5pubmed: 35018604google scholar: lookup
                47. Hou H, Wang Y, Tian L, Wang F, Sun Z, Chen Z. Pythium insidiosum keratitis reported in China, raising the alertness to this fungus-like infection: a case series. J Med Case Rep 2021 Dec 17;15(1):619.
                  doi: 10.1186/s13256-021-03189-3pubmed: 34915928google scholar: lookup
                48. Rodríguez N, Whitfield-Cargile CM, Chamoun-Emanuelli AM, Hildreth E, Jordan W, Coleman MC. Nasopharyngeal bacterial and fungal microbiota in normal horses and horses with nasopharyngeal cicatrix syndrome. J Vet Intern Med 2021 Nov;35(6):2897-2911.
                  doi: 10.1111/jvim.16307pubmed: 34783081google scholar: lookup
                49. Yolanda H, Krajaejun T. History and Perspective of Immunotherapy for Pythiosis. Vaccines (Basel) 2021 Sep 26;9(10).
                  doi: 10.3390/vaccines9101080pubmed: 34696188google scholar: lookup
                50. Rotchanapreeda T, Sae-Chew P, Lohnoo T, Yingyong W, Rujirawat T, Kumsang Y, Payattikul P, Jaturapaktrarak C, Intaramat A, Pathomsakulwong W, Yurayart C, Krajaejun T. Immunological Cross-Reactivity of Proteins Extracted from the Oomycete Pythium insidiosum and the Fungus Basidiobolus ranarum Compromises the Detection Specificity of Immunodiagnostic Assays for Pythiosis. J Fungi (Basel) 2021 Jun 11;7(6).
                  doi: 10.3390/jof7060474pubmed: 34208304google scholar: lookup
                51. Gómez-Pérez D, Kemen E. Predicting Lifestyle from Positive Selection Data and Genome Properties in Oomycetes. Pathogens 2021 Jun 25;10(7).
                  doi: 10.3390/pathogens10070807pubmed: 34202069google scholar: lookup
                52. Chechi JL, Rotchanapreeda T, da Paz GS, Prado AC, Oliveira AL, Vieira JCS, Buzalaf MAR, Rodrigues AM, Santos LDD, Krajaejun T, Bosco SMG. Prospecting Biomarkers for Diagnostic and Therapeutic Approaches in Pythiosis. J Fungi (Basel) 2021 May 28;7(6).
                  doi: 10.3390/jof7060423pubmed: 34071174google scholar: lookup
                53. Krajaejun T, Kittichotirat W, Patumcharoenpol P, Rujirawat T, Lohnoo T, Yingyong W. Genome data of four Pythium insidiosum strains from the phylogenetically-distinct clades I, II, and III. BMC Res Notes 2021 May 21;14(1):197.
                  doi: 10.1186/s13104-021-05610-ypubmed: 34020710google scholar: lookup
                54. Arora H, Sharma A, Sharma S, Haron FF, Gafur A, Sayyed RZ, Datta R. Pythium Damping-Off and Root Rot of Capsicum annuum L.: Impacts, Diagnosis, and Management. Microorganisms 2021 Apr 13;9(4).
                  doi: 10.3390/microorganisms9040823pubmed: 33924471google scholar: lookup
                55. Anitha V, Vanathi M. Commentary: A retrospective multifactorial analysis of Pythium keratitis and review of the literature. Indian J Ophthalmol 2021 May;69(5):1101-1102.
                  doi: 10.4103/ijo.IJO_3660_20pubmed: 33913841google scholar: lookup
                56. Gurnani B, Christy J, Narayana S, Rajkumar P, Kaur K, Gubert J. Retrospective multifactorial analysis of Pythium keratitis and review of literature. Indian J Ophthalmol 2021 May;69(5):1095-1101.
                  doi: 10.4103/ijo.IJO_1808_20pubmed: 33913840google scholar: lookup
                57. Mar Htun Z, Laikul A, Pathomsakulwong W, Yurayart C, Lohnoo T, Yingyong W, Kumsang Y, Payattikul P, Sae-Chew P, Rujirawat T, Jittorntam P, Jaturapaktrarak C, Chongtrakool P, Krajaejun T. Identification and Biotyping of Pythium insidiosum Isolated from Urban and Rural Areas of Thailand by Multiplex PCR, DNA Barcode, and Proteomic Analyses. J Fungi (Basel) 2021 Mar 24;7(4).
                  doi: 10.3390/jof7040242pubmed: 33804838google scholar: lookup
                58. Jara M, Holcomb K, Wang X, Goss EM, Machado G. The Potential Distribution of Pythium insidiosum in the Chincoteague National Wildlife Refuge, Virginia. Front Vet Sci 2021;8:640339.
                  doi: 10.3389/fvets.2021.640339pubmed: 33681336google scholar: lookup
                59. Atiba A, Ghazy A, Hamad MH. Evaluating the efficacy of surgical excision and topical dimethyl sulphoxide (DMSO) in the treatment of equine cutaneous pythiosis. Iran J Vet Res 2020 Fall;21(4):301-307.
                  pubmed: 33584843
                60. Ebani VV, Mancianti F. Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections. Vet Sci 2020 Nov 30;7(4).
                  doi: 10.3390/vetsci7040193pubmed: 33266079google scholar: lookup
                61. do Carmo PMS, Uzal FA, Riet-Correa F. Diseases caused by Pythium insidiosum in sheep and goats: a review. J Vet Diagn Invest 2021 Jan;33(1):20-24.
                  doi: 10.1177/1040638720968937pubmed: 33155523google scholar: lookup
                62. Chindamporn A, Kammarnjessadakul P, Kesdangsakonwut S, Banlunara W. A case of canine cutaneous pythiosis in Thailand. Access Microbiol 2020;2(4):acmi000109.
                  doi: 10.1099/acmi.0.000109pubmed: 33005872google scholar: lookup
                63. White AG, Smart K, Hathcock T, Tillson DM, Poudel A, Rynders P, Wang C. Successful management of cutaneous paralagenidiosis in a dog treated with mefenoxam, minocycline, prednisone, and hyperbaric oxygen therapy. Med Mycol Case Rep 2020 Sep;29:38-42.
                  doi: 10.1016/j.mmcr.2020.07.003pubmed: 32775178google scholar: lookup
                64. Krajaejun T, Kittichotirat W, Patumcharoenpol P, Rujirawat T, Lohnoo T, Yingyong W. Draft genome sequence of the oomycete Pythium destruens strain ATCC 64221 from a horse with pythiosis in Australia. BMC Res Notes 2020 Jul 9;13(1):329.
                  doi: 10.1186/s13104-020-05168-1pubmed: 32646477google scholar: lookup
                65. Rotchanapreeda T, Kumsang Y, Sae-Chew P, Rujirawat T, Lohnoo T, Yingyong W, Payattikul P, Reamtong O, Krajaejun T. Expression, purification, and characterization of the recombinant exo-1,3-β-glucanase (Exo1) of the pathogenic oomycete Pythium insidiosum. Heliyon 2020 Jun;6(6):e04237.
                  doi: 10.1016/j.heliyon.2020.e04237pubmed: 32596527google scholar: lookup
                66. Mandalasi M, Kim HW, Thieker D, Sheikh MO, Gas-Pascual E, Rahman K, Zhao P, Daniel NG, van der Wel H, Ichikawa HT, Glushka JN, Wells L, Woods RJ, Wood ZA, West CM. A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii. J Biol Chem 2020 Jul 3;295(27):9223-9243.
                  doi: 10.1074/jbc.RA120.013792pubmed: 32414843google scholar: lookup
                67. Sae-Chew P, Rujirawat T, Kumsang Y, Payattikul P, Lohnoo T, Yingyong W, Jaturapaktrarak C, Rotchanapreeda T, Reamtong O, Srisuk T, Kittichotirat W, Krajaejun T. Automated Cell-Free Multiprotein Synthesis Facilitates the Identification of a Secretory, Oligopeptide Elicitor-Like, Immunoreactive Protein of the Oomycete Pythium insidiosum. mSystems 2020 May 12;5(3).
                  doi: 10.1128/mSystems.00196-20pubmed: 32398276google scholar: lookup
                68. Yolanda H, Krajaejun T. Review of methods and antimicrobial agents for susceptibility testing against Pythium insidiosum. Heliyon 2020 Apr;6(4):e03737.
                  doi: 10.1016/j.heliyon.2020.e03737pubmed: 32322727google scholar: lookup
                69. Jaturapaktrarak C, Payattikul P, Lohnoo T, Kumsang Y, Laikul A, Pathomsakulwong W, Yurayart C, Tonpitak W, Krajaejun T. Protein A/G-based enzyme-linked immunosorbent assay for detection of anti-Pythium insidiosum antibodies in human and animal subjects. BMC Res Notes 2020 Mar 6;13(1):135.
                  doi: 10.1186/s13104-020-04981-ypubmed: 32143691google scholar: lookup
                70. Chitasombat MN, Jongkhajornpong P, Lekhanont K, Krajaejun T. Recent update in diagnosis and treatment of human pythiosis. PeerJ 2020;8:e8555.
                  doi: 10.7717/peerj.8555pubmed: 32117626google scholar: lookup
                71. Worasilchai N, Chindamporn A, Plongla R, Torvorapanit P, Manothummetha K, Chuleerarux N, Permpalung N. In Vitro Susceptibility of Thai Pythium insidiosum Isolates to Antibacterial Agents. Antimicrob Agents Chemother 2020 Mar 24;64(4).
                  doi: 10.1128/AAC.02099-19pubmed: 32015039google scholar: lookup
                72. Faure C, Veyssière M, Boëlle B, San Clemente H, Bouchez O, Lopez-Roques C, Chaubet A, Martinez Y, Bezouška K, Suchánek M, Gaulin E, Rey T, Dumas B. Long-Read Genome Sequence of the Sugar Beet Rhizosphere Mycoparasite Pythium oligandrum. G3 (Bethesda) 2020 Feb 6;10(2):431-436.
                  doi: 10.1534/g3.119.400746pubmed: 31792008google scholar: lookup
                73. Dowst M, Pavuk A, Vilela R, Vilela C, Mendoza L. An unusual case of cutaneous feline pythiosis. Med Mycol Case Rep 2019 Dec;26:57-60.
                  doi: 10.1016/j.mmcr.2019.10.004pubmed: 31737473google scholar: lookup
                74. Maeno S, Oie Y, Sunada A, Tanibuchi H, Hagiwara S, Makimura K, Nishida K. Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol. Am J Ophthalmol Case Rep 2019 Sep;15:100498.
                  doi: 10.1016/j.ajoc.2019.100498pubmed: 31289761google scholar: lookup
                75. Krajaejun T, Lohnoo T, Yingyong W, Rujirawat T, Kumsang Y, Jongkhajornpong P, Theerawatanasirikul S, Kittichotirat W, Reamtong O, Yolanda H. The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum. Antimicrob Agents Chemother 2019 Aug;63(8).
                  doi: 10.1128/AAC.00609-19pubmed: 31138572google scholar: lookup
                76. Hasika R, Lalitha P, Radhakrishnan N, Rameshkumar G, Prajna NV, Srinivasan M. Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation. Indian J Ophthalmol 2019 Jan;67(1):42-47.
                  doi: 10.4103/ijo.IJO_445_18pubmed: 30574890google scholar: lookup
                77. Krajaejun T, Kittichotirat W, Patumcharoenpol P, Rujirawat T, Lohnoo T, Yingyong W. Data on whole genome sequencing of the oomycete Pythium insidiosum strain CBS 101555 from a horse with pythiosis in Brazil. BMC Res Notes 2018 Dec 11;11(1):880.
                  doi: 10.1186/s13104-018-3968-3pubmed: 30537981google scholar: lookup
                78. Loreto ES, Tondolo JSM, de Jesus FPK, Verdi CM, Weiblen C, de Azevedo MI, Kommers GD, Santurio JM, Zanette RA, Alves SH. Efficacy of Azithromycin and Miltefosine in Experimental Systemic Pythiosis in Immunosuppressed Mice. Antimicrob Agents Chemother 2019 Jan;63(1).
                  doi: 10.1128/AAC.01385-18pubmed: 30373795google scholar: lookup
                79. Richardson M, Page I. Role of Serological Tests in the Diagnosis of Mold Infections. Curr Fungal Infect Rep 2018;12(3):127-136.
                  doi: 10.1007/s12281-018-0321-1pubmed: 30294405google scholar: lookup
                80. Vilela R, Mendoza L. Human Pathogenic Entomophthorales. Clin Microbiol Rev 2018 Oct;31(4).
                  doi: 10.1128/CMR.00014-18pubmed: 30158298google scholar: lookup
                81. Krajaejun T, Rujirawat T, Kanpanleuk T, Santanirand P, Lohnoo T, Yingyong W, Kumsang Y, Sae-Chew P, Kittichotirat W, Patumcharoenpol P. Biochemical and genetic analyses of the oomycete Pythium insidiosum provide new insights into clinical identification and urease-based evolution of metabolism-related traits. PeerJ 2018;6:e4821.
                  doi: 10.7717/peerj.4821pubmed: 29888122google scholar: lookup
                82. Worasilchai N, Permpalung N, Chongsathidkiet P, Leelahavanichkul A, Mendoza AL, Palaga T, Reantragoon R, Finkelman M, Sutcharitchan P, Chindamporn A. Monitoring Anti-Pythium insidiosum IgG Antibodies and (1→3)-β-d-Glucan in Vascular Pythiosis. J Clin Microbiol 2018 Aug;56(8).
                  doi: 10.1128/JCM.00610-18pubmed: 29848566google scholar: lookup
                83. Tonpitak W, Pathomsakulwong W, Sornklien C, Krajaejun T, Wutthiwithayaphong S. First confirmed case of nasal pythiosis in a horse in Thailand. JMM Case Rep 2018 Jan;5(1):e005136.
                  doi: 10.1099/jmmcr.0.005136pubmed: 29568533google scholar: lookup
                84. Patumcharoenpol P, Rujirawat T, Lohnoo T, Yingyong W, Vanittanakom N, Kittichotirat W, Krajaejun T. Draft genome sequences of the oomycete Pythium insidiosum strain CBS 573.85 from a horse with pythiosis and strain CR02 from the environment. Data Brief 2018 Feb;16:47-50.
                  doi: 10.1016/j.dib.2017.11.002pubmed: 29541657google scholar: lookup
                85. Rujirawat T, Patumcharoenpol P, Lohnoo T, Yingyong W, Kumsang Y, Payattikul P, Tangphatsornruang S, Suriyaphol P, Reamtong O, Garg G, Kittichotirat W, Krajaejun T. Probing the Phylogenomics and Putative Pathogenicity Genes of Pythium insidiosum by Oomycete Genome Analyses. Sci Rep 2018 Mar 7;8(1):4135.
                  doi: 10.1038/s41598-018-22540-1pubmed: 29515152google scholar: lookup
                86. McGowan J, Fitzpatrick DA. Genomic, Network, and Phylogenetic Analysis of the Oomycete Effector Arsenal. mSphere 2017 Nov-Dec;2(6).
                  doi: 10.1128/mSphere.00408-17pubmed: 29202039google scholar: lookup
                87. Kittichotirat W, Patumcharoenpol P, Rujirawat T, Lohnoo T, Yingyong W, Krajaejun T. Draft genome and sequence variant data of the oomycete Pythium insidiosum strain Pi45 from the phylogenetically-distinct Clade-III. Data Brief 2017 Dec;15:896-900.
                  doi: 10.1016/j.dib.2017.10.047pubmed: 29159227google scholar: lookup
                88. Fortin JS, Calcutt MJ, Kim DY. Sublingual pythiosis in a cat. Acta Vet Scand 2017 Sep 26;59(1):63.
                  doi: 10.1186/s13028-017-0330-zpubmed: 28950884google scholar: lookup
                89. Tondolo JSM, Loreto ÉS, Ledur PC, Jesus FPK, Silva TM, Kommers GD, Alves SH, Santurio JM. Chemically induced disseminated pythiosis in BALB/c mice: A new experimental model for Pythium insidiosum infection. PLoS One 2017;12(5):e0177868.
                  doi: 10.1371/journal.pone.0177868pubmed: 28542438google scholar: lookup
                90. McCarthy CGP, Fitzpatrick DA. Phylogenomic Reconstruction of the Oomycete Phylogeny Derived from 37 Genomes. mSphere 2017 Mar-Apr;2(2).
                  doi: 10.1128/mSphere.00095-17pubmed: 28435885google scholar: lookup
                91. Inêz-Ferreira TM, Mendoza L, Vilela R, Andrade HM, Haddad JP, Nunes FF, Gondim IM, Guimarães TM, de Toledo VP. A Leishmania murine model to evaluate the immunomodulatory properties of Pythium insidiosum proteins. Heliyon 2017 Mar;3(3):e00278.
                  doi: 10.1016/j.heliyon.2017.e00278pubmed: 28393124google scholar: lookup
                92. Trolezi R, Azanha JM, Paschoal NR, Chechi JL, Dias Silva MJ, Fabris VE, Vilegas W, Kaneno R, Fernandes Junior A, Bosco SM. Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies. Ann Clin Microbiol Antimicrob 2017 Feb 23;16(1):7.
                  doi: 10.1186/s12941-017-0183-3pubmed: 28231795google scholar: lookup
                93. Lerksuthirat T, Sangcakul A, Lohnoo T, Yingyong W, Rujirawat T, Krajaejun T. Evolution of the Sterol Biosynthetic Pathway of Pythium insidiosum and Related Oomycetes Contributes to Antifungal Drug Resistance. Antimicrob Agents Chemother 2017 Apr;61(4).
                  doi: 10.1128/AAC.02352-16pubmed: 28115356google scholar: lookup
                94. Konradt G, Bassuino DM, Bianchi MV, Castro L, Caprioli RA, Pavarini SP, Santurio JM, Azevedo MI, Jesus FP, Driemeier D. Cutaneous Pythiosis in calves: An epidemiologic, pathologic, serologic and molecular characterization. Med Mycol Case Rep 2016 Dec;14:24-26.
                  doi: 10.1016/j.mmcr.2016.11.004pubmed: 28050341google scholar: lookup
                95. He H, Liu H, Chen X, Wu J, He M, Zhong X. Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review. Am J Case Rep 2016 Dec 27;17:982-988.
                  doi: 10.12659/ajcr.901158pubmed: 28025573google scholar: lookup
                96. Grant D, Glass R, Hansen R, Vilela R, Mendoza L. Cutaneous pythiosis in a Red Brangus beef calf cured by immunotherapy. Med Mycol Case Rep 2016 Dec;14:1-3.
                  doi: 10.1016/j.mmcr.2016.11.005pubmed: 27995050google scholar: lookup
                97. de Souza Silveira Valente J, de Oliveira da Silva Fonseca A, Brasil CL, Sagave L, Flores FC, de Bona da Silva C, Sangioni LA, Pötter L, Santurio JM, de Avila Botton S, Pereira DI. In Vitro Activity of Melaleuca alternifolia (Tea Tree) in Its Free Oil and Nanoemulsion Formulations Against Pythium insidiosum. Mycopathologia 2016 Dec;181(11-12):865-869.
                  doi: 10.1007/s11046-016-0051-2pubmed: 27544535google scholar: lookup
                98. Araújo MJ, Bosco SM, Sforcin JM. Pythium insidiosum: inhibitory effects of propolis and geopropolis on hyphal growth. Braz J Microbiol 2016 Oct-Dec;47(4):863-869.
                  doi: 10.1016/j.bjm.2016.06.008pubmed: 27522931google scholar: lookup
                99. Jo Y, Choi H, Cho WK. Genome Sequence of Dengue virus 3 from the Pythium insidiosum Transcriptomes. Front Microbiol 2016;7:926.
                  doi: 10.3389/fmicb.2016.00926pubmed: 27379056google scholar: lookup
                100. Itaqui SR, Verdi CM, Tondolo JS, da Luz TS, Alves SH, Santurio JM, Loreto ÉS. In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum. Antimicrob Agents Chemother 2016 Aug;60(8):5023-5.
                  doi: 10.1128/AAC.00154-16pubmed: 27216049google scholar: lookup
                101. de Souza Silveira Valente J, de Oliveira da Silva Fonseca A, Denardi LB, Dal Ben VS, de Souza Maia Filho F, Baptista CT, Braga CQ, Zambrano CG, Alves SH, de Avila Botton S, Pereira DI. In Vitro Susceptibility of Pythium insidiosum to Melaleuca alternifolia, Mentha piperita and Origanum vulgare Essential Oils Combinations. Mycopathologia 2016 Aug;181(7-8):617-22.
                  doi: 10.1007/s11046-016-0019-2pubmed: 27209011google scholar: lookup
                102. Khunkhet S, Rattanakaemakorn P, Rajatanavin N. Pythiosis presenting with digital gangrene and subcutaneous nodules mimicking medium vessel vasculitis. JAAD Case Rep 2015 Nov;1(6):399-402.
                  doi: 10.1016/j.jdcr.2015.09.005pubmed: 27051792google scholar: lookup
                103. Mendoza L, Taylor JW, Walker ED, Vilela R. Description of three novel Lagenidium (Oomycota) species causing infection in mammals. Rev Iberoam Micol 2016 Apr-Jun;33(2):83-91.
                  doi: 10.1016/j.riam.2015.07.005pubmed: 26924580google scholar: lookup
                104. Inkomlue R, Larbcharoensub N, Karnsombut P, Lerksuthirat T, Aroonroch R, Lohnoo T, Yingyong W, Santanirand P, Sansopha L, Krajaejun T. Development of an Anti-Elicitin Antibody-Based Immunohistochemical Assay for Diagnosis of Pythiosis. J Clin Microbiol 2016 Jan;54(1):43-8.
                  doi: 10.1128/JCM.02113-15pubmed: 26719582google scholar: lookup
                105. Jesus FP, Loreto ÉS, Ferreiro L, Alves SH, Driemeier D, Souza SO, França RT, Lopes ST, Pilotto MB, Ludwig A, Azevedo MI, Ribeiro TC, Tondolo JS, Santurio JM. In Vitro and In Vivo Antimicrobial Activities of Minocycline in Combination with Azithromycin, Clarithromycin, or Tigecycline against Pythium insidiosum. Antimicrob Agents Chemother 2016 Jan;60(1):87-91.
                  doi: 10.1128/AAC.01480-15pubmed: 26459895google scholar: lookup
                106. Keeratijarut A, Lohnoo T, Rujirawat T, Yingyong W, Kalambaheti T, Miller S, Phuntumart V, Krajaejun T. The Immunoreactive Exo-1,3-β-Glucanase from the Pathogenic Oomycete Pythium insidiosum Is Temperature Regulated and Exhibits Glycoside Hydrolase Activity. PLoS One 2015;10(8):e0135239.
                  doi: 10.1371/journal.pone.0135239pubmed: 26263509google scholar: lookup
                107. Rujirawat T, Patumcharoenpol P, Lohnoo T, Yingyong W, Lerksuthirat T, Tangphatsornruang S, Suriyaphol P, Grenville-Briggs LJ, Garg G, Kittichotirat W, Krajaejun T. Draft Genome Sequence of the Pathogenic Oomycete Pythium insidiosum Strain Pi-S, Isolated from a Patient with Pythiosis. Genome Announc 2015 Jun 18;3(3).
                  doi: 10.1128/genomeA.00574-15pubmed: 26089407google scholar: lookup
                108. Lerksuthirat T, Lohnoo T, Inkomlue R, Rujirawat T, Yingyong W, Khositnithikul R, Phaonakrop N, Roytrakul S, Sullivan TD, Krajaejun T. The elicitin-like glycoprotein, ELI025, is secreted by the pathogenic oomycete Pythium insidiosum and evades host antibody responses. PLoS One 2015;10(3):e0118547.
                  doi: 10.1371/journal.pone.0118547pubmed: 25793767google scholar: lookup
                109. Vilela R, Taylor JW, Walker ED, Mendoza L. Lagenidium giganteum pathogenicity in mammals. Emerg Infect Dis 2015 Feb;21(2):290-7.
                  doi: 10.3201/eid2102.141091pubmed: 25625190google scholar: lookup
                110. Lelievre L, Borderie V, Garcia-Hermoso D, Brignier AC, Sterkers M, Chaumeil C, Lortholary O, Lanternier F. Imported pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler. Am J Trop Med Hyg 2015 Feb;92(2):270-3.
                  doi: 10.4269/ajtmh.14-0380pubmed: 25535313google scholar: lookup
                111. Fonseca AO, Pereira DI, Jacob RG, Maia Filho FS, Oliveira DH, Maroneze BP, Valente JS, Osório LG, Botton SA, Meireles MC. In vitro susceptibility of Brazilian Pythium insidiosum isolates to essential oils of some Lamiaceae family species. Mycopathologia 2015 Apr;179(3-4):253-8.
                  doi: 10.1007/s11046-014-9841-6pubmed: 25431090google scholar: lookup
                112. Loreto ES, Tondolo JS, Pilotto MB, Alves SH, Santurio JM. New insights into the in vitro susceptibility of Pythium insidiosum. Antimicrob Agents Chemother 2014 Dec;58(12):7534-7.
                  doi: 10.1128/AAC.02680-13pubmed: 25223997google scholar: lookup
                113. Pan JH, Kerkar SP, Siegenthaler MP, Hughes M, Pandalai PK. A complicated case of vascular Pythium insidiosum infection treated with limb-sparing surgery. Int J Surg Case Rep 2014;5(10):677-80.
                  doi: 10.1016/j.ijscr.2014.05.018pubmed: 25194603google scholar: lookup
                114. Pang KL, Lin HJ, Lin HY, Huang YF, Chen YM. Production of arachidonic and eicosapentaenoic acids by the marine oomycete Halophytophthora. Mar Biotechnol (NY) 2015 Apr;17(2):121-9.
                  doi: 10.1007/s10126-014-9600-1pubmed: 25119161google scholar: lookup
                115. Jesus FP, Ferreiro L, Loreto ÉS, Pilotto MB, Ludwig A, Bizzi K, Tondolo JS, Zanette RA, Alves SH, Santurio JM. In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum. Antimicrob Agents Chemother 2014 Sep;58(9):5621-5.
                  doi: 10.1128/AAC.02349-14pubmed: 25001300google scholar: lookup
                116. Tuuminen T, Viiri H, Vuorinen S. The Capnocytophaga canimorsus isolate that caused sepsis in an immunosufficient man was transmitted by the large pine weevil Hylobius abietis. J Clin Microbiol 2014 Jul;52(7):2716-7.
                  doi: 10.1128/JCM.00640-14pubmed: 24808240google scholar: lookup
                117. Keoprasom N, Chularojanamontri L, Chayakulkeeree M, Chaiprasert A, Wanachiwanawin W, Ruangsetakit C. Vascular pythiosis in a thalassemic patient presenting as bilateral leg ulcers. Med Mycol Case Rep 2012 Dec 8;2:25-8.
                  doi: 10.1016/j.mmcr.2012.12.002pubmed: 24432209google scholar: lookup
                118. Fonseca AO, Botton Sde A, Nogueira CE, Corrêa BF, Silveira Jde S, de Azevedo MI, Maroneze BP, Santurio JM, Pereira DI. In vitro reproduction of the life cycle of Pythium insidiosum from kunkers' equine and their role in the epidemiology of pythiosis. Mycopathologia 2014 Feb;177(1-2):123-7.
                  doi: 10.1007/s11046-013-9720-6pubmed: 24326464google scholar: lookup
                119. Pereira DI, Botton SA, Azevedo MI, Motta MA, Lobo RR, Soares MP, Fonseca AO, Jesus FP, Alves SH, Santurio JM. Canine gastrointestinal pythiosis treatment by combined antifungal and immunotherapy and review of published studies. Mycopathologia 2013 Oct;176(3-4):309-15.
                  doi: 10.1007/s11046-013-9683-7pubmed: 23918089google scholar: lookup
                120. Salas Y, Márquez A, Canelón J, Perazzo Y, Colmenárez V, López JA. Equine pythiosis: report in crossed bred (Criole Venezuelan) horses. Mycopathologia 2012 Dec;174(5-6):511-7.
                  doi: 10.1007/s11046-012-9562-7pubmed: 22772508google scholar: lookup
                121. Mahl DL, de Jesus FP, Loreto É, Zanette RA, Ferreiro L, Pilotto MB, Alves SH, Santurio JM. In vitro susceptibility of Pythium insidiosum isolates to aminoglycoside antibiotics and tigecycline. Antimicrob Agents Chemother 2012 Jul;56(7):4021-3.
                  doi: 10.1128/AAC.00073-12pubmed: 22508303google scholar: lookup
                122. Salipante SJ, Hoogestraat DR, SenGupta DJ, Murphey D, Panayides K, Hamilton E, Castañeda-Sánchez I, Kennedy J, Monsaas PW, Mendoza L, Stephens K, Dunn JJ, Cookson BT. Molecular diagnosis of subcutaneous Pythium insidiosum infection by use of PCR screening and DNA sequencing. J Clin Microbiol 2012 Apr;50(4):1480-3.
                  doi: 10.1128/JCM.06126-11pubmed: 22205808google scholar: lookup
                123. Santos CE, Marques LC, Zanette RA, Jesus FP, Santurio JM. Does immunotherapy protect equines from reinfection by the oomycete Pythium insidiosum?. Clin Vaccine Immunol 2011 Aug;18(8):1397-9.
                  doi: 10.1128/CVI.05150-11pubmed: 21715582google scholar: lookup
                124. Loreto ES, Mario DA, Denardi LB, Alves SH, Santurio JM. In vitro susceptibility of Pythium insidiosum to macrolides and tetracycline antibiotics. Antimicrob Agents Chemother 2011 Jul;55(7):3588-90.
                  doi: 10.1128/AAC.01586-10pubmed: 21537028google scholar: lookup
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