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Home / Equine Research Bank / J Vet Intern Med / Relationship between equine herpesvirus-1 viremia and aborti...
Journal of veterinary internal medicine2023; 38(3); 1872-1891; doi: 10.1111/jvim.16948

Relationship between equine herpesvirus-1 viremia and abortion or equine herpesvirus myeloencephalopathy in domesticated horses: A systematic review.

Abstract: Equine herpes virus type 1 (EHV-1) infection in horses is associated with upper respiratory disease, neurological disease, abortions, and neonatal death. Objective: To determine if there is an association between the level and duration of EHV-1 viremia and either abortion or equine herpesvirus myeloencephalopathy (EHM) in domesticated horses? Methods: A systematic review was performed searching numerous databases to identify peer reviewed reports that evaluated viremia and EHM, or viremia and abortion published before January 19, 2021. Randomized controlled trials and observational studies were assessed for risk of bias or publication quality. Results: A total of 189 unique studies were identified, of which 34 met the inclusion criteria. Thirty studies evaluated viremia and neurologic outcomes including 4 observational studies. Eight experimental studies examined viremia and abortion, which used the Ab4 and OH03 virus strains or recombinant Ab4 derivatives. Incidence rates for both EHM and abortion in experimental studies varied among the studies as did the level of evidence. Viremia was generally detectable before the onset of either EHM or abortion. Risk of bias was generally low to moderate, sample sizes were small, and multiple studies reported negative outcome data. Conclusions: The results of this study support that viremia is regularly present before EHM or abortion occurs. However, no inferences could be made about the relationship between the occurrence of either neurological signs or abortion and the magnitude or duration of viremia.
© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2023-12-09 PubMed ID: 38069576PubMed Central: PMC11099755DOI: 10.1111/jvim.16948Google Scholar: Lookup
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  • Systematic Review
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is a systematic review that examines the association between Equine Herpes Virus type 1 (EHV-1) viremia and the onset of equine herpesvirus myeloencephalopathy (EHM) or abortion in horses.

Objective and Methodology

  • The main objective of this research was to establish whether there is a connection between the level and duration of EHV-1 viremia (presence of the virus in the bloodstream) and the occurrence of either abortion or EHM in domestic horses.
  • The researchers conducted a systematic review using multiple databases, searching for peer-reviewed reports that have evaluated the relationship between viremia and EHM or viremia and abortion in horses. The review considered studies published before January 19, 2021.
  • Both randomized controlled trials and observational studies were reviewed. The authors also evaluated each study’s risk of bias and the overall quality.

Results

  • Upon searching, the researchers found 189 unique studies, out of which 34 satisfied the inclusion criteria for the review.
  • From these, 30 studies had evaluated the relationship between viremia and neurological outcomes, including four observational studies. Similarly, eight experimental studies had examined viremia and abortion, using specific virus strains (Ab4 and OH03) or recombinant Ab4 derivatives.
  • The studies indicated that the incidence rates for both EHM and abortion varied from one study to another, as did the level of provided evidence.
  • In general, viremia was detectable before the onset of EHM or abortion. However, the studies had low to moderate risk of bias, small sample sizes, and several reported negative outcome data.

Conclusions

  • The findings of this systematic review suggest that viremia consistently precedes the occurrence of either EHM or abortion. However, the authors stipulated that this research did not offer conclusive evidence about the relationship between the occurrence of neurological signs or abortion and the magnitude or duration of viremia.

Cite This Article

APA
Soboll-Hussey G, Dorman DC, Burgess BA, Goehring L, Gross P, Neinast C, Osterrieder K, Pusterla N, Lunn DP. (2023). Relationship between equine herpesvirus-1 viremia and abortion or equine herpesvirus myeloencephalopathy in domesticated horses: A systematic review. J Vet Intern Med, 38(3), 1872-1891. https://doi.org/10.1111/jvim.16948

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 38
Issue: 3
Pages: 1872-1891

Researcher Affiliations

Soboll-Hussey, Gisela
  • College of Veterinary Medicine, Michigan State University, Veterinary Medical Center, Room G331, 784 Wilson Road, East Lansing, Michigan 48824, USA.
Dorman, David C
  • College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA.
Burgess, Brandy A
  • College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, Georgia 30602, USA.
Goehring, Lutz
  • College of Agriculture, Food and Environment, Maxwell H. Gluck Equine Research Center, University of Kentucky, 1400 Nicholasville Road, Lexington, Kentucky 40546-0099, USA.
Gross, Peggy
  • College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA.
Neinast, Claire
  • College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, North Carolina 27607, USA.
Osterrieder, Klaus
  • Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Strasse 7, Berlin 14163, Germany.
Pusterla, Nicola
  • School of Veterinary Medicine, University of California, Davis, One Garrod Drive, Davis, California 95616, USA.
Lunn, David P
  • School of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, United Kingdom.

MeSH Terms

  • Horses
  • Animals
  • Herpesvirus 1, Equid
  • Horse Diseases / virology
  • Viremia / veterinary
  • Herpesviridae Infections / veterinary
  • Herpesviridae Infections / virology
  • Abortion, Veterinary / virology
  • Female
  • Pregnancy

Conflict of Interest Statement

Authors declare no conflict of interest.

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