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Frontiers in microbiology2024; 15; 1327210; doi: 10.3389/fmicb.2024.1327210

Response of serum biochemical profile, antioxidant enzymes, and gut microbiota to dietary Hong-bailanshen supplementation in horses.

Abstract: Traditional Chinese medicine (TCM) is widely used in humans and animals, which is very important for health. TCM affects the body 's immunity and changes in intestinal flora. This study was conducted to investigate the effects of dietary Hong-bailanshen (HBLS) supplementation in horses on serum biochemical profile, antioxidant enzymes and gut microbiota. Unassigned: In this study, five horses were selected. On day 0, 14, 28, blood samples and feces were collected on days 0, 14, and 28 to analyse gut microbiota, serum biochemical and redox indexes. Unassigned: The results showed that the addition of HBLS to horse diets significantly decreased the level of alanine aminotransferase, alkaline phosphatase, creatine kinase and malondialdehyde ( < 0.05, < 0.01) and significantly increased the activity of total antioxidant capacity, superoxide dismutase and catalase ( < 0.05, < 0.01). Compared with day 14, the levels of alanine aminotransferase, alkaline phosphatase and creatine kinase were significantly decreased; however, the level of catalase was significantly increased in the horses continuously fed with HBLS for 28 days ( < 0.05, < 0.01). Alpha diversity analysis was performed that chao1 ( < 0.05), observed_specicies, faith'pd and goods_coverage upregulated in the horses fed HBLS. A total of 24 differential genera were detected adding HBLS to diet increased the abundance of and , while reduced and ( < 0.05, < 0.01). Unassigned: Adding HBLS to the diet could be a potentially effective strategy to improve horses' health.
Copyright © 2024 Ding, Gu, Meng, Hu, Wang and Liu.
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Publication Date: 2024-02-20 PubMed ID: 38444806PubMed Central: PMC10912594DOI: 10.3389/fmicb.2024.1327210Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigated the effects of Hong-bailanshen, a traditional Chinese medicine, on the health of horses, focusing on its impact on serum biochemical profile, antioxidant enzymes and gut microbiota. The study found significant improvement in various health parameters, suggesting a potential strategy to improve horse health.

Objective of the Research

  • The aim of this study was to investigate the effects of Hong-bailanshen (HBLS), a form of traditional Chinese medicine, on the overall health of horses. It specifically examined the impact on horses’ serum biochemical profile, antioxidant enzyme activity, and gut microbiota.

Methodology

  • Five horses were chosen for the experiment. Their blood samples and feces were collected at the start of the study, then again on the 14th and 28th days.
  • The collected samples were analyzed to track the changes in gut microbiota, serum biochemical, and redox indexes.

Findings of the Research

  • The results showed that adding HBLS to the horse’s diet significantly decreased harmful compounds like alanine aminotransferase, alkaline phosphatase, creatine kinase, and malondialdehyde.
  • At the same time, the supplementation increased beneficial factors like the total antioxidant capacity, superoxide dismutase, and catalase activities.
  • Particularly, by the 28th day of continuous HBLS feeding, it was found that harmful compounds had significantly decreased while the beneficial enzyme catalase had significantly increased in level.
  • Alpha diversity analysis revealed an increase in chao1, observed species, faith’pd, and goods coverage when horses were fed HBLS.
  • A total of 24 different genera were identified and the introduction of HBLS to the diet was seen to increase the abundance of certain beneficial species while reducing others.

Conclusion

  • The research concluded that incorporating HBLS into a horse’s diet could potentially be an effective strategy in improving the health of horses, evidenced by improvements in biochemical, enzymatic, and gut microbiota measures.

Cite This Article

APA
Ding J, Gu B, Meng J, Hu M, Wang W, Liu J. (2024). Response of serum biochemical profile, antioxidant enzymes, and gut microbiota to dietary Hong-bailanshen supplementation in horses. Front Microbiol, 15, 1327210. https://doi.org/10.3389/fmicb.2024.1327210

Publication

Frontiers in microbiology
ISSN: 1664-302X
NlmUniqueID: 101548977
Country: Switzerland
Language: English
Volume: 15
Pages: 1327210
PII: 1327210

Researcher Affiliations

Ding, Jinxue
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Gu, Bolin
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Meng, Jinwu
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Hu, Mengxin
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Wang, Wenjia
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Liu, Jiaguo
  • Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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