Successful hemodialysis treatment of a Quarter Horse mare with silver maple leaf toxicity and acute kidney injury.
Abstract: An adult American Quarter Horse mare presented for pigmenturia and lethargy of 12 hours' duration and was diagnosed with silver maple leaf toxicity. The mare had intravascular hemolysis and azotemia. The mare was treated with a transfusion of whole blood, fluids administered IV, antibiotics, oxygen insufflation, and supportive care. The azotemia persisted despite conventional medical management and hemodialysis was elected. After 2 intermittent hemodialysis treatments over 3 days, the azotemia almost resolved, clinical signs improved, and the mare was discharged. The blood urea nitrogen, creatinine, and electrolyte concentrations remained normal 6 months later after examination by the referring veterinarian. Hemodialysis treatment can be feasible in horses if equipment and expertise are available and should be considered as a treatment option if indicated.
© 2024 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Publication Date: 2024-04-29 PubMed ID: 38682859DOI: 10.1111/jvim.17094Google Scholar: Lookup
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Summary
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The research article talks about a Quarter Horse mare that was successfully treated through hemodialysis for acute kidney injury and toxicity caused by silver maple leaves.
Introduction
- This case study involves an American Quarter Horse mare that showed symptoms like pigmenturia (dark-colored urine) and lethargy, which had persisted for 12 hours.
- The mare was diagnosed with silver maple leaf toxicity, a condition characterized by intravascular hemolysis (rupture of red blood cells) and azotemia (abnormally high levels of nitrogen-containing compounds in the blood).
Treatment Protocol
- The mare was given a whole blood transfusion, intravenous fluids, antibiotics, and oxygen insufflation along with supportive care.
- Despite these interventions, the azotemia did not show signs of improvement, prompting the decision for hemodialysis (a treatment for kidney failure that filters waste and extra fluid from your blood).
Hemodialysis Procedure
- The mare underwent two intermittent hemodialysis treatments across a span of three days.
- Following the hemodialysis, clinical signs of the condition improved and the azotemia almost completely resolved leading to the discharge of the mare.
Follow-up and Conclusion
- At a follow-up examination six months later by the referring veterinarian, the mare’s blood urea nitrogen, creatinine, and electrolyte concentrations remained within normal range.
- The study concludes that hemodialysis treatment can be a feasible treatment option for horses with conditions like the one presented if expertise and necessary equipment are available.
Cite This Article
APA
Pinnell EF, Her J, Gordon D, Kinsella HM, Langston CE, Toribio RE.
(2024).
Successful hemodialysis treatment of a Quarter Horse mare with silver maple leaf toxicity and acute kidney injury.
J Vet Intern Med.
https://doi.org/10.1111/jvim.17094 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington, USA.
- Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
- Department of Nephrology and Extracorporeal Therapies, Colorado Animal Specialty and Emergency, Boulder, Colorado, USA.
- Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
- Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
- Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
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