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Emerging microbes & infections2021; 10(1); 2199-2201; doi: 10.1080/22221751.2021.2003724

Susceptibility of livestock to SARS-CoV-2 infection.

Abstract: We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2. None of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral RNA was detected in several animals. Further, neutralizing antibody titres were low or non-existent one month following infection. These results suggest that domestic livestock are unlikely to contribute to SARS-CoV-2 epidemiology.
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Publication Date: 2021-11-10 PubMed ID: 34749583PubMed Central: PMC8635583DOI: 10.1080/22221751.2021.2003724Google Scholar: Lookup
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  • Comparative Study
  • Letter

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores the vulnerability of common domestic livestock (like cattle, sheep, goats, alpacas, rabbits, and horses) to SARS-CoV-2 infection. Researchers found that these animals do not shed the infectious virus, implying they are unlikely to contribute to the spread of the virus.

Objective of the Research

  • The main goal of this study was to determine the susceptibility of standard domestic livestock—cattle, sheep, goats, alpacas, rabbits, and horses—to the SARS-CoV-2 intranasal infection.
  • Researchers wanted to understand if these animals could shed the infectious virus through different routes, namely nasal, oral, or faecal. The understanding of the infection dynamics in these animals would greatly help in structuring the epidemiology of SARS-CoV-2.

Methodology of the Research

  • The team carried out pilot experiments which involved infecting animals intranasally with the virus.
  • Post infection, they observed and examined the animals for shedding the infectious virus through nasal, oral, or faecal routes.
  • To confirm the presence of the SARS-CoV-2 virus, viral RNA was tested in several animals.
  • Finally, the presence and quantity of neutralizing antibodies were also gauged a month after the infection.

Findings of the Research

  • None of the infected animals released the infectious virus either via the nasal path, orally, or through faecal matter.
  • During testing, viral RNA was discovered in some of the animals, indicating that they were indeed infected.
  • However, neutralizing antibody titers were either low or non-existent in the animals a month following the infection, suggesting that the animals’ immune response towards the virus was minimal.

Conclusion

  • The findings imply that domestic livestock may not play a significant role in the spread of the SARS-CoV-2 virus.
  • This is due to the fact that they do not shed the infectious virus, and exhibit a low or even non-existent immune response.
  • This study therefore contributes to the body of knowledge regarding the epidemiology of SARS-CoV-2, providing valuable insights for managing the spread of the virus.

Cite This Article

APA
Bosco-Lauth AM, Walker A, Guilbert L, Porter S, Hartwig A, McVicker E, Bielefeldt-Ohmann H, Bowen RA. (2021). Susceptibility of livestock to SARS-CoV-2 infection. Emerg Microbes Infect, 10(1), 2199-2201. https://doi.org/10.1080/22221751.2021.2003724

Publication

Emerging microbes & infections
ISSN: 2222-1751
NlmUniqueID: 101594885
Country: United States
Language: English
Volume: 10
Issue: 1
Pages: 2199-2201

Researcher Affiliations

Bosco-Lauth, Angela M
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Walker, Audrey
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Guilbert, Lauren
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Porter, Stephanie
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Hartwig, Airn
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
McVicker, Emma
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Bielefeldt-Ohmann, Helle
  • School of Chemistry & Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia.
Bowen, Richard A
  • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

MeSH Terms

  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology
  • COVID-19 / immunology
  • COVID-19 / veterinary
  • COVID-19 / virology
  • Camelids, New World / virology
  • Cattle / virology
  • Chlorocebus aethiops
  • Disease Reservoirs / virology
  • Goats / virology
  • Horses / virology
  • Host Specificity / immunology
  • Humans
  • Livestock / virology
  • Nasal Cavity / virology
  • RNA, Viral / analysis
  • Rabbits / virology
  • Rectum / virology
  • Respiratory System / virology
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / pathogenicity
  • Sheep / virology
  • Species Specificity
  • Vero Cells
  • Virus Shedding
  • Viscera / virology

Conflict of Interest Statement

No potential conflict of interest was reported by the author(s).

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