[The detrimental effect of iodine as an intra-uterine instillation in mares].
Abstract: Fifty ml of a 0.2% iodine solution were instilled into the uteri of six mares selected for culling. Biopsy specimens were taken for microscopic examination before the commencement of the experiment and at various times over the course of a year after the single instillation. Severe oedema and haemorrhage was present in the lamina propria of all the post-instillation biopsy specimens. The epithelium showed vacuolisation and necrosis, as well as focal areas of epithelial loss. In some cases hyperplasia or metaplasia was seen. Cell infiltration was characterized by the presence of neutrophils, eosinophils and mild lymphocyte infiltration around the blood vessels. Leukostasis was present around the blood vessels in some specimens. Blood vessel changes were characterized in the early stages by oedema of the tunica media of the medium-sized arteries and later by arteriosclerosis with the complete obliteration of the lumen of the particular vessels in some cases. The endometrial glands showed hyperplasia and mitotic figures were more often seen in these glands than normal. The most pronounced lesion in the later stage of the experiment was fibrosis of the lamina propria with the resultant collapse of the stratum compactum and contraction of the stratum spongiosum. The severe fibrosis of the endometrium is the most probable reason for infertility in mares treated with iodine.
Publication Date: 1986-12-01 PubMed ID: 3572955
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- English Abstract
- Journal Article
Summary
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The research article studies the harmful effects of iodine when applied into the uterus of mares. It finds that iodine may lead to severe medical complications, including changes in the uterine lining, swelling, hemorrhaging, and fibrosis, which could result in infertility.
Research Methodology
- The study was conducted on six mares that were selected for culling. The treatment involved instilling 50 ml of a 0.2% iodine solution into their uteri.
- Biopsy specimens were taken from each mare before the iodine solution was instilled (to establish a baseline), then at various intervals over the course of a year after the application of the solution.
Findings
- Negative effects of the iodine solution were documented at every post-instillation biopsy. These included severe swelling (oedema) and hemorrhaging in the uterine lining (lamina propria) of all mares.
- There were noticeable alterations in the epithelium, such as cell death (necrosis), hollow spaces (vacuolisation) and focal areas of epithelial loss.
- In some mares, abnormal increases in the reproduction of cells (hyperplasia) or the transformation of cells (metaplasia) were observed.
- The researchers noted cell infiltration, characterized by the notable presence of white blood cells (neutrophils and eosinophils) and a mild collection of lymphocytes around the blood vessels.
- Some biopsy samples also showed leukostasis (a sort of arrest of blood flow) around the blood vessels.
- Initial blood vessel changes were marked by oedema of the middle layer of arterial walls (tunica media). Over time, the mares developed arteriosclerosis (hardening of the arteries) which in some cases completely closed off the lumen, or the interior canal, of the affected vessels.
- The uterine glands showed hyperplasia; cell division (mitosis) was more frequently observed in these glands as opposed to normal conditions.
- Later stages of the experiment showed fibrosis (formation of extra fibrous tissue leading to scarring and thickening) in the uterine lining. This resulted in the collapsing of the upper layer of the uterine wall (stratum compactum) and contraction of the spongy underlying layer (stratum spongiosum).
- The study concludes that the severe fibrosis of the uterine lining is most likely the cause of fertility issues in mares treated with iodine.
Cite This Article
APA
van Dyk E, Lange AL.
(1986).
[The detrimental effect of iodine as an intra-uterine instillation in mares].
J S Afr Vet Assoc, 57(4), 205-210.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Endometrium / pathology
- Female
- Horse Diseases / chemically induced
- Horses
- Infertility, Female / chemically induced
- Infertility, Female / veterinary
- Iodine / adverse effects
- Male
- Time Factors
Citations
This article has been cited 4 times.- Dring JC, Forma A, Chilimoniuk Z, Dobosz M, Teresiński G, Buszewicz G, Flieger J, Cywka T, Januszewski J, Baj J. Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers-A State-of-the-Art Review. Nutrients 2021 Dec 31;14(1).
- Del Llano E, Rasschaert M, Arnoult C, Robert P, Ray PF, Loeuillet C. Administration of ethiodized poppy seed oil-based contrast agent into the uterus enhances fertilization rate in mice inseminated with low sperm numbers. Hum Reprod 2026 Jan 1;41(1):69-77.
- Kapper C, Oppelt P, Ganhör C, Gyunesh AA, Arbeithuber B, Stelzl P, Rezk-Füreder M. Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health. Nutrients 2024 Mar 29;16(7).
- Xie B, Huang Y, Hang F, Yu J, Hu Q, Li J, Qin A. Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study. Reprod Biol Endocrinol 2024 Feb 3;22(1):19.
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