The isoflurane sparing effect of a medetomidine constant rate infusion in horses.
Abstract: No abstract available
Publication Date: 2016-11-15 PubMed ID: 28404428DOI: 10.1046/j.1467-2995.2003.00132_8.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The researchers conducted a clinical study examining the impact of a medetomidine constant rate infusion on isoflurane usage during horse surgeries. The results showed a significant reduction in the usage of isoflurane for anesthetic maintenance when infused with medetomidine.
Study Overview
- The clinical trial randomly assigned forty healthy horses undergoing either orthopaedic or soft tissue surgeries into two groups, group A and group B.
- All horses were given acepromazine prior to sedation. For sedation, group A received xylazine, while group B was given medetomidine.
- Both groups were then induced with ketamine and diazepam, and anesthetized with isoflurane in 100% oxygen.
- Additionally, group B received a constant rate infusion of medetomidine.
- Several parameters, such as respiratory rate and heart rate, were monitored and recorded every five minutes.
- If required, dobutamine was given to maintain arterial blood pressure above 70mm Hg.
Results
- There were no significant differences between the two groups in terms of horses’ body mass or the duration of the anaesthesia.
- Lower amounts of isoflurane were required to maintain the surgical plane of anaesthesia in group B, indicating a significant sparing effect of the medetomidine infusion on isoflurane use.
- Heart rate and dobutamine requirements were noticeably lower in group B.
- There were no significant differences between the two groups in terms of respiratory rate, carbon dioxide levels, and oxygen and carbon dioxide partial pressures.
- Adjusting the depth of anaesthesia was reportedly easier in group B compared to group A, contributing to an overall smoother administration process.
- Less horses showed purposeful movements in group B, and this group also required fewer supplemental doses of thiopental or ketamine.
- Overall, the research clearly indicated that the use of a constant rate infusion of medetomidine during isoflurane anaesthesia significantly reduced the requirement of isoflurane in horses.
Cite This Article
APA
Neges K, Bettschart-Wolfensberger R, Müller J, Fürst A, Kästner S.
(2016).
The isoflurane sparing effect of a medetomidine constant rate infusion in horses.
Vet Anaesth Analg, 30(2), 92-93.
https://doi.org/10.1046/j.1467-2995.2003.00132_8.x Publication
Researcher Affiliations
- Department for Horses, Faculty of Veterinary Medicine of the University of Zürich, Zürich, Switzerland.
- Department for Horses, Faculty of Veterinary Medicine of the University of Zürich, Zürich, Switzerland.
- Department for Horses, Faculty of Veterinary Medicine of the University of Zürich, Zürich, Switzerland.
- Department for Horses, Faculty of Veterinary Medicine of the University of Zürich, Zürich, Switzerland.
- Department for Horses, Faculty of Veterinary Medicine of the University of Zürich, Zürich, Switzerland.
Citations
This article has been cited 3 times.- Straticò P, Varasano V, Guerri G, Celani G, Palozzo A, Petrizzi L. A Retrospective Study of Cryptorchidectomy in Horses: Diagnosis, Treatment, Outcome and Complications in 70 Cases. Animals (Basel) 2020 Dec 21;10(12).
- Tokushige H, Okano A, Arima D, Ito H, Kambayashi Y, Minamijima Y, Ohta M. Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Acta Vet Scand 2018 Nov 5;60(1):71.
- Straticò P, Guerri G, Bandera L, Celani G, Di Nunzio L, Petrizzi L, Varasano V. Comparison of Xylazine and Lidocaine Infusion versus Medetomidine Continuous Rate Infusion during General Anesthesia with Isoflurane in Horses Undergoing Emergency Laparotomy. Vet Sci 2024 Apr 29;11(5).
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