Annals of surgery.
Publisher:
Lippincott Williams & Wilkins
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Surgical Association.
Start Year:1885 -
ISSN:
0003-4932 (Print)
1528-1140 (Electronic)
0003-4932 (Linking)
1528-1140 (Electronic)
0003-4932 (Linking)
Impact Factor
9
| NLM ID: | 0372354 |
| (DNLM): | A35505000(s) |
| (OCoLC): | 01481411 |
| Coden: | ANSUA5 |
| LCCN: | 44048195 |
| Classification: | W1 AN626 |
Seven years’ experience with antilymphoblast globulin for renal transplantation from cadaver donors. Antibody of the IgGab type can be isolated from horses immunized with cultured human lymphoblasts plus complete Freund's adjuvant. The essential steps for the production of a safe, potent anti-human lymphoblast globulin (ALG) are: A) the use of early bleedings after immunization to reduce the titer of antibodies which react with red blood cells and platelets; B) careful absorption with human red blood cell stroma and platelets; C) stabilization with non-crystalline silica dioxide; D) chromatography through QAE sephadex to remove pyrogens, microaggregates and possible inhibitors of ALG activity...
Clinical evaluation of equine antithymocyte globulin in recipients of renal allografts: Analysis of survival, renal function, rejection, histocompatibility, and complications. Equine antithymocyte globulin combined with azathioprine and prednisone as immunosuppressive therapy in 50 transplant recipients prolonged allograft survival and seemed to modify the severity of rejection episodes. Although nine patients died from a variety of causes, only three kidneys were lost to rejection, one of which was hyperacute. There were no serious untoward hematologic or systemic effects caused by the ATG, and all patients completed the course of therapy. Infection, a serious and frequent complication of transplant patients, was encountered no more often than in other transplant s...