British journal of rheumatology.
Discontinued
Publisher:
Published for the British Association for Rheumatology and Rehabilitation by Baillière Tindall,. Oxford, UK : Oxford University Press (1998)
Frequency: Monthly
Country: England
Language: English
Author(s):
British Association for Rheumatology and Rehabilitation., British Society for Rheumatology.
Start Year:1983 - 1998
ISSN:
0263-7103 (Print)
0263-7103 (Linking)
0263-7103 (Linking)
Impact Factor
5.5
2022
| NLM ID: | 8302415 |
| (DNLM): | B35530000(s) |
| (OCoLC): | 09272712 |
| Coden: | BJRHDF |
| Classification: | W1 BR625F |
Release of lubricating synovial surfactant by intra-articular steroid. This study was undertaken to determine whether glucocorticosteroids promote the secretion of lubricating surfactant, i.e. surface-active phospholipid (SAPL), into the joint. A standard clinical dose (100 mg) of methylprednisolone acetate (MPA) in 2.5 ml of saline was injected into the load-bearing right radiocarpal joint of five horses and 2.5 ml of saline injected into each of the contralateral joints used as controls. Synovial fluid (SF) was aspirated from all 10 joints before injection and at intervals of 16 and 32 h after injection, and then analysed by standard methods. All test joints sh...
Loading-induced changes in synovial fluid affect cartilage metabolism. The purpose of this study was to determine whether changes in the synovial fluid (SF) induced by in vivo loading can induce an alteration in the metabolic activity of chondrocytes in vitro. Therefore, SF was collected from ponies after a period of box rest and after they had exercise for a week. Normal, unloaded articular cartilage explants were cultured in 20% solutions of these SFs for 4 days and chondrocyte activity was determined by glycosaminoglycan (GAG) turnover. In explants cultured in post-exercise SF, GAG synthesis was enhanced and GAG release was diminished when compared to cultures...
Synovial surfactant: lamellar bodies in type B synoviocytes and proteolipid in synovial fluid and the articular lining. Previous studies have shown that synovial surfactant could have beneficial roles in the joint, especially as a very effective boundary lubricant capable of high load bearing. This study is aimed at further characterization and identification of the source. Known to be an important minor component of pulmonary surfactant, proteolipid has now been detected in appreciable quantities in bovine synovial fluid and bound to the articular surface. Using standard procedures to separate it from the major component [surface-active phospholipid (SAPL)] by column chromatography, proteolipid: phospholipid r...