Cancer research.
Publisher:
American Association for Cancer Research. Baltimore, Md. : American Association for Cancer Research
Frequency: Semimonthly
Country: United States
Language: English
Author(s):
American Association for Cancer Research.
Start Year:1941 -
ISSN:
0008-5472 (Print)
1538-7445 (Electronic)
0008-5472 (Linking)
1538-7445 (Electronic)
0008-5472 (Linking)
Impact Factor
11.2
2023
| NLM ID: | 257598 |
| (DNLM): | C05900000(s) |
| (OCoLC): | 01553285 |
| Coden: | CNREA8 |
| Classification: | W1 CA688 |
Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Misregulation of the Wnt/beta-catenin signaling pathway is a hallmark of several forms of cancer. Components of the Wnt/beta-catenin pathway are expressed in ovarian granulosa cells; nevertheless, its potential involvement in granulosa cell tumorigenesis has not been examined. To this end, human (n = 6) and equine (n = 18) granulosa cell tumors (GCT) were analyzed for beta-catenin expression by immunohistochemistry. Unlike granulosa cells of normal ovaries, most (15 of 24) GCT samples showed nuclear localization of beta-catenin, suggesting that activation of the Wnt/beta-catenin pathway plays ...