Head & face medicine.
Publisher:
BioMed Central,
Country: England
Language: English
Start Year:2005 -
ISSN:
1746-160X (Electronic)
1746-160X (Linking)
1746-160X (Linking)
Impact Factor
3
2022
| NLM ID: | 101245792 |
| (OCoLC): | 61396483 |
| LCCN: | 2006243253 |
Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model. Current approaches in bone regeneration combine osteoconductive scaffolds with bioactive cytokines like BMP or VEGF. The idea of our in-vitro trial was to apply VEGF165 in gradient concentrations to an equine collagen carrier and to study pharmacological and morphological characteristics of the complex in a circulation model. Methods: Release kinetics of VEGF165 complexed in different quantities in a collagen matrix were determined in a circulation model by quantifying protein concentration with ELISA over a period of 5 days. The structural changes of the collagen matrix were assessed with lig...