Journal of neuroinflammation.
Publisher:
BioMed Central,
Country: England
Language: English
Author(s):
BioMed Central Ltd.
Start Year:2004 -
ISSN:
1742-2094 (Electronic)
1742-2094 (Linking)
1742-2094 (Linking)
Impact Factor
9.3
2022
| NLM ID: | 101222974 |
| (OCoLC): | 55064649 |
| LCCN: | 2004243769 |
Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis. Müller glial cells are important regulators of physiological function of retina. In a model disease of retinal inflammation and spontaneous recurrent uveitis in horses (ERU), we could show that retinal Müller glial cells significantly change potassium and water channel protein expression during autoimmune pathogenesis. The most significantly changed channel protein in neuroinflammatory ERU was aquaporin 11 (AQP11). Aquaporins (AQP, 13 members) are important regulators of water and small solute transport through membranes. AQP11 is an unorthodox member of this family and was assigned to a thi...