National science review.
Publisher:
China Science Publishing ;
Frequency: Monthly, 2020-
Country: China
Language: English
Author(s):
Zhongguo ke xue yuan,
Start Year:2014 -
ISSN:
2053-714X (Electronic)
2095-5138 (Print)
2053-714X (Linking)
2095-5138 (Print)
2053-714X (Linking)
Impact Factor
20.6
| NLM ID: | 101633095 |
| (OCoLC): | 1160100301 |
| LCCN: | 2021229601 |
| Classification: | W1 |
Convergent genomic signatures of high-altitude adaptation among domestic mammals. Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the gene in these Tibetan domest...