Neurotoxicology.
Publisher:
Pathotox Publishers.. Amsterdam : Elsevier Science (2001)
Frequency: Bimonthly, 1998-
Country: Netherlands
Language: English
Start Year:1979 -
ISSN:
0161-813X (Print)
1872-9711 (Electronic)
0161-813X (Linking)
1872-9711 (Electronic)
0161-813X (Linking)
Impact Factor
3.4
2022
| NLM ID: | 7905589 |
| (DNLM): | N13880100(s) |
| (OCoLC): | 05034026 |
| Coden: | NRTXDN |
| Classification: | W1 NE3494HB |
Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse disease induced by HR ingestion. So, the present study was conducted to assess the brain metabolome and the behavioural performances of mice fed with a 9%-HR-based diet for 21 days. By the end of the period of exposure, mice were investigated for motor activity and coordination, anx...
Characterization of the role of glutathione in repin-induced mitochondrial dysfunction, oxidative stress and dopaminergic neurotoxicity in rat pheochromocytoma (PC12) cells. Repin, a major constituent in extracts of the plant Centaurea repens is thought to be the active principal responsible for the development of equine nigropallidal encephalomalacia (ENE), a fatal Parkinson-like neurodegenerative disorder in horses. Although the exact mechanism by which ingestion of this weed causes ENE is uncertain, a limited body of experimental evidence suggests a critical role for the glutathione redox system. In the present study, the mechanism of repin neurotoxicity was examined in PC12 cells with a focus on determining the role of glutathione (GSH) in repin-induced mitoch...