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A genome-wide association study for quantitative trait loci of show-jumping in Hanoverian warmblood horses.
Abstract: Show-jumping is an economically important breeding goal in Hanoverian warmblood horses. The aim of this study was a genome-wide association study (GWAS) for quantitative trait loci (QTL) for show-jumping in Hanoverian warmblood horses, employing the Illumina equine SNP50 Beadchip. For our analyses, we genotyped 115 stallions of the National State stud of Lower Saxony. The show-jumping talent of a horse includes style and ability in free-jumping. To control spurious associations based on population stratification, two different mixed linear animal model (MLM) approaches were employed, besides linear models with fixed effects only and adaptive permutations for correcting multiple testing. Population stratification was explained best in the MLM considering Hanoverian, Thoroughbred, Trakehner and Holsteiner genes and the marker identity-by-state relationship matrix. We identified six QTL for show-jumping on horse chromosomes (ECA) 1, 8, 9 and 26 (-log(10) P-value >5) and further putative QTL with -log(10) P-values of 3-5 on ECA1, 3, 11, 17 and 21. Within six QTL regions, we identified human performance-related genes including PAPSS2 on ECA1, MYL2 on ECA8, TRHR on ECA9 and GABPA on ECA26 and within the putative QTL regions NRAP on ECA1, and TBX4 on ECA11. The results of our GWAS suggest that genes involved in muscle structure, development and metabolism are crucial for elite show-jumping performance. Further studies are required to validate these QTL in larger data sets and further horse populations.
© 2011 The Authors, Animal Genetics © 2011 Stichting International Foundation for Animal Genetics.
Publication Date: 2011-10-12 PubMed ID: 22497689DOI: 10.1111/j.1365-2052.2011.02265.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research study explores the genetic factors contributing to show-jumping abilities in Hanoverian warmblood horses. This was achieved through a genome-wide association study (GWAS) identifying the most influential genetic loci, or Quantitative Trait Loci (QTL), associated with the ability and style for show-jumping.
Research Methodology
The researchers utilized genotyping to identify variations in the genetic makeup of the horses being studied. The genotyping was done using the Illumina equine SNP50 Beadchip on a sample set of 115 stallions from the National State stud of Lower Saxony. The research employed a variety of statistical models including:
- Mixed linear animal model (MLM) to address potential spurious associations due to population stratification.
- Linear models with fixed effects only and adaptive permutations for the purpose of correcting multiple testing
Results
The researchers found that the most adequate stratification was considering Hanoverian, Thoroughbred, Trakehner and Holsteiner genes and the marker identity-by-state relationship matrix. The team identified six quantitive trait loci (QTL) for show-jumping on four specific horse chromosomes 1, 8, 9, and 26, along with additional potential QTL on chromosomes 1, 3, 11, 17, and 21.
In six identified QTL regions, the team located several human performance-related genes such as PAPSS2, MYL2, TRHR, and GABPA. In the putative QTL regions, additional genes identified included NRAP and TBX4.
Conclusion
The results highlight the crucial role of genes involved in muscle structure, development, and metabolism for elite show-jumping performance. This provides some insight into the genetic factors that contribute to the ability of Hanoverian warmblood horses to excel in show-jumping. However, the researchers stress that further studies are necessary to validate these findings in larger datasets and in other horse populations. The research findings may have implications on breeding programs aimed at show-jumping performance.
Cite This Article
APA
Schröder W, Klostermann A, Stock KF, Distl O.
(2011).
A genome-wide association study for quantitative trait loci of show-jumping in Hanoverian warmblood horses.
Anim Genet, 43(4), 392-400.
https://doi.org/10.1111/j.1365-2052.2011.02265.x Publication
Researcher Affiliations
- Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany.
MeSH Terms
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes, Mammalian
- Female
- Gene Frequency
- Genetic Association Studies / methods
- Horses / genetics
- Linear Models
- Male
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
Citations
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